The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide-polyketide natural product biosynthesis

Journal of Industrial Microbiology and Biotechnology

Volumn 27, Issue 6, 2001, Pages 378-385

  Shen, B ^a   Du, L ^a   Sanchez, C ^a   Edwards, D J ^a   Chen, M ^a   Murrell, J M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biosynthesis; Bleomycin; Hybrid peptide polyketide; Nonribosomal peptide synthetase; Polyketide synthase; Streptomyces verticillus

Indexed keywords

ACYL CARRIER PROTEIN; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; PEPTIDE SYNTHASE; POLYKETIDE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; GENE CLUSTER; MODEL; NONHUMAN; REACTION ANALYSIS; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES VERTICILLUS;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; GENES, BACTERIAL; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; PEPTIDE SYNTHASES; STREPTOMYCES;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES VERTICILLUS; UNCULTURED ACTINOMYCETE;

EID: 0035673048     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.7000194     Document Type: Article

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