Ligand-dependent and -independent processes in B-cell-receptor-mediated signaling

Springer Seminars in Immunopathology

Volumn 23, Issue 4, 2001, Pages 333-350

  Fuentes Panana E M ^a   Monroe, J G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

B cell; BCR; Development; Ligand binding; Signal transduction

Indexed keywords

BRUTON TYROSINE KINASE; CALCIUM; CD19 ANTIGEN; CD45 ANTIGEN; CHOLESTEROL; COMPLEMENT COMPONENT C3D RECEPTOR; DIACYLGLYCEROL; GLYCOSYLPHOSPHATIDYLINOSITOL; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN; PROTEIN BLNK; PROTEIN KINASE; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; SPHINGOLIPID; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VAV PROTEIN;

B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BIOSENSOR; CALCIUM CELL LEVEL; CELL MATURATION; CELL SURFACE; CELL SURVIVAL; CYTOLOGY; ENZYME ACTIVATION; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; B-LYMPHOCYTES; BONE MARROW; CELL DIFFERENTIATION; DNA NUCLEOTIDYLTRANSFERASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MACROMOLECULAR SUBSTANCES; MAMMALS; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; SPLEEN; SRC-FAMILY KINASES; VDJ RECOMBINASES;

EID: 0035671436     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s281-001-8163-6     Document Type: Review

References (73)

1. Ordered rearrangement of immunoglobulin heavy chain variable region segments
2. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells
3. Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre- B lymphocytes and receptor-ligated B cells
4. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis
5. Role of the mu immunoglobulin heavy chain transmem-brane and cytoplasmic domains in B cell antigen receptor expression and signal transduction
6. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
7. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor ty-rosine-based activation motif (ITAM)
8. Defective negative regulation of antigen receptor signaling in Lyn- deficient B lymphocytes
9. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
10. Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling
11. Floating the raft hypothesis: The roles of lipid rafts in B cell antigen receptor function
12. The B cell antigen receptor complex: Association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors
13. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
14. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
15. Role of Btk in B cell development and signaling
16. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
17. Floating the raft hypothesis for immune receptors: Access to rafts controls receptor signaling and trafficking
18. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
19. Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene
20. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation
21. Intermediary signaling effectors coupling the B-cell receptor to the nucleus
22. Regulation of an early developmental checkpoint in the B cell pathway by Ig beta
23. Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta
24. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex
25. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
26. Molecular components of the B-cell antigen receptor complex of the IgM class
27. Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor
28. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
29. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo
30. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase
31. Signal transduction via the B-cell antigen receptor: The role of protein tyrosine kinases and protein tyrosine phosphatases
32. The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain
33. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice
34. A critical role of lambda 5 protein in B cell development
35. Genetic analysis of B cell antigen receptor signaling
36. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
37. BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly
38. Immuno-deficiency in protein kinase cbeta-deficient mice
39. Adapters in lymphocyte signalling
40. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
41. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
42. IgD can largely substitute for loss of IgM function in B cells
43. Fit for life in the immune system? Surrogate L chain tests H chains that test L chains
44. Mutations within the NH2-terminal trans-membrane domain of membrane immunoglobulin (Ig) M alters Ig alpha and Ig beta association and signal transduction
45. B-cell antigen receptor signaling in immature-stage B cells: Integrating intrinsic and extrinsic signals
46. Balancing signals for negative selection and activation of developing B lymphocytes
47. Adapter proteins in lymphocyte antigen-receptor signaling
48. The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation
49. Murine B lymphopoiesis: Towards a unified model
50. Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: Evidence toward a role in calcium regulation
51. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons
52. Stromal cell-independent maturation of IL-7-responsive pro-B cells
53. Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development
54. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
55. Stability of the B cell antigen receptor complex
56. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
57. Detection and characterization of T-cell leukemia virus-like proviral sequences in PBL and tissues of baboons by PCR
58. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development
59. Activated Ras signals developmental progression of recombinase- activating gene (RAG)-deficient pro-B lymphocytes
60. Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells
61. Introduction: Response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction
62. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
63. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface
64. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
65. Pleiotropic changes controlled by the pre-T-cell receptor
66. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells
67. Evidence for a preformed transducer complex organized by the B cell antigen receptor
68. The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes
69. The sequence of the mu trans-membrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface
70. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
71. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling
72. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
73. Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk