The evolution of the MHC-G gene does not support a functional role for the complete protein

Immunological Reviews

Volumn 183, Issue , 2001, Pages 65-75

  Arnaiz Villena, Antonio ^a   Martinez Laso, Jorge ^a   Castro, Maria Jose ^a   Morales, Pablo ^a   Moscoso, Juan ^a   Varela, Pilar ^a   Gomez Casado, Eduardo ^a   Allende, Luis M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HISTOCOMPATIBILITY ANTIGEN; HLA G ANTIGEN;

ALLELE; ANTIGEN PRESENTATION; CERCOPITHECUS; GENE; HLA SYSTEM; HUMAN; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC G GENE; MOLECULAR EVOLUTION; MONKEY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CEBIDAE; CERCOPITHECIDAE; EVOLUTION, MOLECULAR; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC;

EID: 0035661286     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1830105.x     Document Type: Review

References (66)

1. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment
2. Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule
3. Characterization of an expressible nonclassical class I HLA gene
4. Lack of HLA-G soluble isoforms in Graves-Basedow thyrocytes and complete cDNA sequence of the HLA-G*01012 allele
5. Impaired spontaneous endocytosis of HLA-G
6. Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells
7. Shared regulatory elements in the promoters of MHC class I and class II genes
8. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens
9. A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4
10. Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells
11. The functionality of HLA-G is emerging
12. A class I antigen, HLA-G, expressed in human trophoblasts
13. Analysis of HLA-G mRNA in human placental and extraplacental membrane cells by in situ hybridization
14. In situ hybridization and Northern blot demonstration of HLA-G mRNA in human trophoblast populations by locus-specific oligonucleotide
15. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts
16. The human amnion is a site of MHC class Ib expression: Evidence for the expression of HLA-E and HLA-G
17. HLA-G expression during preimplantation human embryo development
18. Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolisis
19. The HLA-G gene is expressed at a low mRNA level in different human cells and tissues
20. Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts
21. Evolution of the MHC class I gene of a New Word primate from ancestral homologies of human non-classical genes
22. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus): Natural selection acts at positions that may affect the peptide presentation to T cells
23. Evolutionary instability of the major histocompatibility complex class I loci in New World primates
24. Description of a new kind of MHC DNA sequence in Saguinus oedipus (cotton-top tamarin)
25. Primate Mhc-E and -G alleles
26. An evolutionary overview of the MHC-G polymorphism: Clues to the unknown function(s)
27. The role of peptide presentation in the physiological function of HLA-G
28. High polymorphism of Mhc-E locus in non-human primates: Alleles with identical exon 2 and 3 are found in two different species
29. Allelic diversity at the primate Mhc-G locus: Exon 3 bears stop codons in all Cercophitecinae sequences
30. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations
31. Characterization of a point mutation in aspartyl glucosamidase gene: Evidence for a readthrough of a translational stop codon
32. Transcription and weak expression of HLA-DRB6: A gene with anomalies in exon 1 and other regions
33. Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locus
34. Lack of MHC-G4 and soluble (G5, G6) isoforms in the higher primates, Pongidae
35. Homozygous HLA-G*0105N healthy individuals indicate that membrane-anchored HLA-G1 molecule is not necessary for survival
36. Identification of the rhesus monkey HLA-G ortholog. Mamu-G is a pseudogene
37. Evolution of MHC-G in primates: A different kind of molecule for each group of species
38. HLA-G polymorphism: 12th International Histocompatibility Workshop study
39. Detection of HLA-E and -G DNA alleles for population and disease studies
40. HLA-G1 protein expression is not essential for fetal survival
41. Three new HLA-G alleles and their linkage disequilibria with HLA-A
42. Population genetics studies of HLA-G: Allele frequencies and linkage disequilibrium with HLA-A
43. HLA-G gene polymorphism in a Japanese population
44. A new HLA-G allele (HLA-G*0105N) and its distribution in the Spanish population
45. HLA-G gene polymorphism segregation within CEPH reference families
46. Characterization of a new HLA-G allele encoding a nonconservative amino acid substitution in the α3 domain (exon 4) and its relevance to certain complications in pregnancy
47. HLA-G polymorphism: Neutral evolution or novel function?
48. Complete cDNA sequences of DRB6 gene from humans and chimpanzees: A possible model of a stop codone reading-through mechanism in primates
49. Evolution of MHC-G in humans and primates based on three new 3' UT polymorphism
50. HLA allele and haplotype frequencies in Algerians
51. The contribution of the HLA-A, -B, -C and -DR, -DQ DNA typing to the study of the origins of Spaniards and Basques
52. The origin of Cretan populations as determined by characterization of HLA alleles
53. Analysis of human leukocyte antigen-G polymorphism including intron 4 in Japanese couples with habitual abortion
54. The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion
55. HLA-G expression in trophoblast cells is independent of embryonic development
56. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
57. HLA-E bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: Preferential response to an HLA-G derived nonamer
58. The ILT2 (LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells
59. Human myelomonocytic cells extress an inhibitory receptor for classical and nonclassical MHC class I molecules
60. P49, a putative HLA class I-specific inhibitory NK receptor belonging to the immunoglobulin superfamily
61. Nonclassical HLA-G molecules are classical peptide presenters
62. HLA-G and HLA-C at the feto-maternal interface: Lessons learned from pathogenic viruses
63. HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
64. HLA-G: A tolerance molecule from the major histocompatibility complex
65. HLA-G protein expression is not induced during malignant transformation