Characterization of a new HLA-G allele encoding a nonconservative amino acid substitution in the α3 domain (exon 4) and its relevance to certain complications in pregnancy

Immunogenetics

Volumn 53, Issue 1, 2001, Pages 48-53

  Hviid, T V F ^a   Christiansen, O B ^a   Johansen, J K ^a   Hviid, U R ^a   Lundegaard, C ^a   Moller C ^a   Morling, N ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

Author keywords

HLA G; Polymorphism; Pre eclampsia; Spontaneous abortion; 3 domain

Indexed keywords

HLA G ANTIGEN; PRIMER DNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CODON; DNA SEQUENCE; EXON; FEMALE; FEMALE INFERTILITY; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; SPONTANEOUS ABORTION; TROPHOBLAST;

ABORTION, HABITUAL; EXONS; FEMALE; FERTILITY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; SEQUENCE ANALYSIS, DNA;

EID: 0035096708     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510100296     Document Type: Article

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2. Nonclassical HLA-G molecules are classical peptide presenters
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4. + cells by interacting with CD8
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6. Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8
7. A human major histocompatibility complex class I gene that encodes a protein with shortened cytoplasmic segment
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9. Altered expression of human leukocyte antigen G(HLA-G) on extravillous trophoblasts in preeclampsia: Immunohistological demonstration with anit-HLA-G specific antibody "87G" and anti-cytokeratin antibody "CAM5.2"
10. Polymorphism of exon 3 of the HLA-G gene
11. Co-dominant expression of the HLA-G gene and various forms of alternatively spliced HLA-G mRNA in human first trimester trophoblast
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13. Human cytomegalovirus gene products US3 and US6 downregulate trophoblast class I MHC molecules
14. HLA-G has a concentration-dependent effect on the generation of an allo-CTL response
15. The functionality of HLA-G is emerging
16. The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association
17. Presence of HLA-G-expressing cells modulates the ability of peripheral blood mononuclear cells to release cytokines
18. ALGORITH 643 FEXACT: A FORTRAN subroutine for Fisher's exact test on unordered rxc contingency tables
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