Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells

Human Immunology

Volumn 61, Issue 11, 2000, Pages 1138-1149

  Paul, Pascale ^a   Adrian Cabestre, Franscisco ^a   Ibrahim, El Chérif ^a   Lefebvre, Sophie ^a   Khalil Daher, Iman ^a   Vazeux, Gilles ^a   Moya Quiles, Rosa Maria ^a   Bermond, Fabienne ^a   Dausset, Jean ^a   Carosella, Edgardo D ^a  

^a Inst Univ d'Hématologie   (France)

Author keywords

Gene transcription; HLA G; Nonclassical HLA class I genes; Soluble HLA; Splice variant

Indexed keywords

HLA ANTIGEN CLASS 1; HLA G ANTIGEN;

ALTERNATIVE RNA SPLICING; ANTIGEN EXPRESSION; BODY FLUID; CANCER CELL CULTURE; CONFERENCE PAPER; DNA SEQUENCE; EXPRESSION VECTOR; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRON; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOP CODON; TRANSLATION REGULATION; WESTERN BLOTTING;

ALTERNATIVE SPLICING; BASE SEQUENCE; BIOPSY; BLOTTING, NORTHERN; BLOTTING, WESTERN; CULTURE MEDIA, CONDITIONED; DNA, COMPLEMENTARY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MELANOMA; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034516969     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(00)00197-X     Document Type: Conference Paper

References (48)

1. A tolerance molecule from the major histocompatibility complex
2. The functionality of HLA-G is emerging
3. A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4
4. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens
5. An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes
6. Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form candidate to encode it in peripheral blood mononuclear cells and human trophoblasts
7. A human major histocompatibility complex class I gene that encodes a protein with shortened cytoplasmic segment
8. The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association
9. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts
10. Evaluation of trophoblast HLA-G antigen with a specific monoclonal antibody
11. Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells
12. Detection of membrane-bound HLA-G translated products with a specific monoclonal antibody
13. HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences
14. Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts
15. Primary cultured human thymic epithelial cells express both membrane-bound and soluble HLA-G translated products
16. Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G
17. The human amnion is a site of MHC class Ib expression: Evidence for the expression of HLA-E and HLA-G
18. HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation
19. Detection of soluble HLA-G molecules in plasma and amniotic fluid
20. HLA-G expression: Immune privilege for tumour cells?
21. Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies
22. Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells
23. HLA-G protein expression is not induced during malignant transformation
24. Non-classic sHLA class I in human oocyte culture medium
25. HLA-G expression during preimplantation human embryo development'
26. Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-γ
27. HLA-G class I gene expression in normal and malignant hematopoietic cells
28. IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
29. Soluble HLA-G in human placentas: Synthesis in trophoblasts and interferon-gamma-activated macrophages but not placental fibroblasts
30. The full length HLA-G1 and no other alternative form of HLA-G is expressed at the cell surface of transfected cells
31. The short forms of HLA-G are unlikely to play a role in pregnancy because they are not expressed at the cell surface
32. Implication of HLA-G molecule in heart-graft acceptance
33. Soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8
34. HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
35. Amnion epithelial cells, in contrast to trophoblast cells, express cell classical class I molecules together with HLA-G
36. HLA-G, -E, -F preworkshop: Tools and protocols for analysis of non classical class I genes transcription and protein expression
37. Evidence for the expression of non-HLA-A, -B, -C class I genes in the human fetal liver
38. Complex alternative splicing of the GH-V gene in the human testis
39. Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta
40. Lack of HLA-G soluble isoforms in Graves-Basedow thyrocytes and complete cDNA sequence of the HLA-G*01012 allele
41. Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines
42. Selective histocompatibility leucocyte antigen (HLA)-A2 loss caused by aberrant pre-mRNA splicing in 624MEL28 melanoma cells
43. Quantitative assessment of human leukocyte antigen-G protein in amniotic fluid by a double-determinant enzyme-linked immunosorbent assay using anti-human leukocyte antigen-G-specific antibody '87G'
44. Determination of soluble HLA-G and HLA-A, -B, and -C molecules in pregnancy
45. Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules
46. Implication of HLA-G in heart graft acceptance
47. A new HLA-G allele (HLA-G*0105N) and its distribution in the Spanish population
48. HLA-G1 protein expression is not essential for fetal survival