Evidence for distinct mechanisms in the shaping of the CD4 T cell repertoire in histologically distinct myasthenia gravis - Associated thymomas

Developmental Immunology

Volumn 8, Issue 3-4, 2001, Pages 279-290

  Strobel P ^a   Helmreich, M ^a   Kalbacher, H ^a   Muller Hermelin H K ^a   Marx, A ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cortical; Epithelium; Medullary; MHC class II; Myasthenia gravis; Thymoma; Thymus

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; CELL MATURATION; CELL SELECTION; CLINICAL ARTICLE; CORRELATION FUNCTION; DISEASE ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MYASTHENIA GRAVIS; PARANEOPLASTIC NEUROPATHY; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; THYMOCYTE; THYMOMA; THYMUS CANCER; TUMOR CLASSIFICATION;

EID: 0035660748     PISSN: 10446672     EISSN: None     Source Type: Journal    
DOI: 10.1155/2001/49127     Document Type: Article

References (74)

1. T-cell-receptor-affinity and thymocyte positive selection
2. CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes
3. Thymic epithelial cells provide unique signals for positive selection of CD4+8+ thymocytes in vitro
4. Positive selection of thymocytes: The long and winding road
5. Genomically imposed and somatically modified human thymocyte V beta gene repertoires
6. In thymic selection, peptide diversity gives and takes away
7. Another view of the selective model of thymocyte selection
8. Myasthenia gravis: Immunohistological heterogeneity in microenvironmental organization of hyperplastic and neoplastic thymuses suggesting different mechanisms of tolerance breakdown
9. STATs and gene regulation
10. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
11. In vivo T-cell clonal amplification at time of acute graft-versus-host disease
12. Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection
13. The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells
14. Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures
15. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24 for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction
16. Complex and differential cytokeratin profiles in thymomas and correlation with normal thymus
17. TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis
18. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
19. Mice lacking major histocompatibility complex class I and class II molecules
20. T-cell selection
21. Few V gene segments dominate the T cell receptor beta-chain repertoire of the human thymus
22. Human thymic epithelial cells present superantigens to T-cell lines and thymocytes
23. Immunoglobulin and T-cell receptor genes in thymomas: Genotypic evidence supporting the nonneoplastic nature of the lymphocytic component
24. Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors
25. Well-differentiated thymic carcinoma: An organotypical low-grade carcinoma with relationship to cortical thymoma
26. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes
27. Analysis of the molecular specificities of anti-class monoclonal antibodies by using L cell transfectants expressing HLA class II molecules
28. TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression
29. Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA
30. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
31. Thymoma and thymic carcinoma
32. Positive selection of thymocytes bearing alpha beta T cell receptors
33. Distribution of molecules mediating thymocyte-stroma-interactions in human thymus, thymitis and thymic epithelial tumors
34. From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The second conference on biological and clinical aspects of thymic epithelial tumors and related recent developments
35. Characterization of peptides bound to extracellular and intracellular HLA-DR1 molecules
36. Engagement of the CD4 molecule influences cell surface expression of the T cell receptor on thymocytes
37. Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-β1-mechanism
38. Advances in the diagnosis and classification of thymic epithelial tumors
39. Characterization of the human thymic microenvironment: Lymphoepithelial interaction in normal thymus and thymoma
40. Thymomas express epitopes shared by the ryanodine receptor
41. TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action
42. TCR-Vbeta usage in the thymus and blood of myasthenia gravis patients
43. Abnormal T lymphocyte development in myasthenia gravis-associated thymomas
44. Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas
45. T-cell repertoire diversity and clonal expansions in normal and clinical samples
46. Primary cultures of human thymic epithelial tumors. Morphological and immunocytochemical characterization
47. Two distinct gamma-interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, Interferon regulatory factor 1, and transforming growth factor β
48. Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture
49. Selective events in T cell development
50. Histological typing of tumours of the thymus
51. Vascular cell adehsion molecule-I is expressed by cortical thymic epithelial cells and mediates thymocyte adhesion. Implications for the function of alpha4beal (VLA4) integrin in T-cell development
52. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire
53. Expression and gene rearrangement of the T-cell receptor in human thymomas
54. Separation of three class II antigens from a homozygous human B cell line
55. Neurofilament is an autoantigenic determinant in myasthenia gravis
56. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells
57. Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC
58. Early progression of thymocytes along the CD4 / CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta
59. Accumulation of immature CD3-CD4+CD8-single-positive cells that lack CD69 in epithelial cell tumors of the human thymus
60. Analysis of immunoglobulin and T cell receptor gene rearrangements in the thymus of myasthenia gravis patients
61. Altered intrathymic T-cell repertoire in human myasthenia gravis
62. Altered peptide ligands and wild-type peptide induce indistinguishable responses of a human ThO clone
63. An immunohistologic study of the epithelial and lymphoid components of six thymomas
64. T cell development in a major histocompatibility complex class II-deficient patient
65. MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes
66. Selectively down-regulated expression of major histocompatibility complex class I alleles in human solid tumors
67. Amino acid residues that flank core peptide epitopes and the extracellular domain of CD4 modulate differential signaling through the T cell receptor
68. Immunohistochemical characterization of the thymic microenvironment. A light-microscopic and ultrastructural immunocytochemical study
69. Titin epitope in thymoma
70. Myasthenic and nonmyasthenic thymoma: An expansion of a minor cortical epithelial cell subset?
71. The agonist-antagonist balance in positive selection
72. Role of CD4 in thymocyte selection and maturation