The 1.6 Å crystal structure of E. coli Argininosuccinate synthetase suggests a conformational change during catalysis

Structure

Volumn 9, Issue 12, 2001, Pages 1153-1164

  Lemke, Christopher T ^a,b   Howell, P Lynne ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

"N type" ATP pyrophosphatase; Argininosuccinate synthetase; Conformational change; Mutation analysis; Structure; Urea cycle

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININOSUCCINATE SYNTHASE; ASPARTIC ACID; CITRULLINE; INORGANIC PYROPHOSPHATASE; SELENOMETHIONINE; NUCLEOTIDE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMAL; ARGININOSUCCINATE SYNTHASE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CITRULLINE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESCHERICHIA COLI; HUMAN; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0035653365     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00683-9     Document Type: Article

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