A computational model of the 5-HT3 receptor extracellular domain: Search for ligand binding sites

Theoretical Chemistry Accounts

Volumn 106, Issue 1-2, 2001, Pages 98-104

  Menziani, Maria Cristina ^a   De Rienzo, Francesca ^a   Cappelli, Andrea ^b   Anzini, Maurizio ^c   De Benedetti, Pier G ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

5 HT3 receptor; Extracellular domain; Ligand binding site; Ligand gated ion channel; Molecular modelling

Indexed keywords

EID: 0035617059     PISSN: 1432881X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002140000214     Document Type: Article

References (36)

1. Karlin A, Akabas MH (1995) Neuron 15: 1231-1244, and references therein
2. Unwin N (1993) J Mol Biol 229: 1101-1124
3. Corringer P-J, Le Novere N, Changeux J-P (2000) Annu Rev Pharmacol Toxicol 40: 431-458
4. Eisele JL, Bertrand S, Galzi JL, Devillers-Thiery A, Changeux J-P, Bertrand D (1993) Nature 366: 469-492
5. Jackson MB, Yakel JL (1995) Annu Rev Physiol 57: 447-468
6. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (1999) Nature 397: 259-363
7. Wohland T, Friedrich K, Hovius R, Vogel H (1999) Biochemistry 38: 8671-8681
8. Le Novere N, Corringer PJ, Changeux J-P (1999) Biophys J 76: 2329-2345
9. Ortella MO (1997) Proteins 29: 391-398
10. Tsigenly I, Sugiyama N, Sine SM, Taylor P (1997) Biophys J 73: 52-56
11. Gready JE, Ranganathan S, Schofield PR, Matsuo T, Nishikawa K (1997) Protein Sci 6: 983-998
12. Cappelli A, Donati A, Anzini M, Vomero S, De Benedetti PG, Menziani MC, Langer T (1996) Bioorg Med Chem 4: 1255-1269
13. Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Bruni G, Romeo MR, Menziani MC, De Benedetti PG, Langer T (1998) J Med Chem 41: 728-741
14. Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A (1999) J Med Chem 42: 1556-1575
15. Thompson JD, Higgins DG, Gibson TJ (1994) Nucleic Acids Res 22: 4673-4680
16. Sali A, Blundell TL (1993) J Mol Biol 234: 779-815
17. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983) J Comput Chem 4: 187-217
18. Vriend G (1990) J Mol Graphics 8: 52-56
19. Hucho F, Tseltlin VI, Machold J (1996) Eur J Biochem 239: 539-557
20. Song X-Z, Pedersen SE (2000) Biophys J 78: 1324-1334
21. Papineni RVL, Pedersen E (1997) J Biol Chem 272: 24891-24898
22. Kreienkamp H-J, Maeda RK, Sine SM, Taylor P (1995) Neuron 14: 635-644
23. Ohno K, Wang HL, Milone M, Bren N, Brengman J, Nakano S, Quiram P, Pruitt J, Sine SM, Engel A (1996) Neuron 17: 157-170
24. Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA (1998) Proc Natl Acad Sci USA 21: 12088-12093
25. Spier AD, Lummis SCR (2000) J Biol Chem 275: 5620-5625
26. Van D, Schulte MK, Bloom KE, White MM (1999) J Biol Chem 274: 5537-5541
27. Fletcher E, Sepulveda MI, Green T, Pinnock R, Lummis SCR (1995) Neurosci Abstr 21: 343
28. Hope AG, Belelli D, Mair ID, Lambert JJ, Peters JA (1999) Mol Pharmacol 55: 1037-1043
29. Sigel E, Schaerer MT, Buhr A, Baur R (1998) Mol Pharmacol 54: 1097-1105
30. Srinivasan S, Nichols CJ, Lawless GM, Olsen RW, Tobin AJ (1999) J Biol Chem 274: 26633-26638
31. Sigel E, Buhr A (1997) Trends Pharmacol Sci 18: 425-429
32. Vafa B, Lewis TM, Cunnigham AM, Jacques P, Lynch JW, Schofield PR (1999) J Neurochem 73: 2158-2166
33. Schmieden V, Kuhse J, Betz H (1999) Mol Pharmacol 56: 464-472
34. Vandenberg RJ, Rajendra S, French CR, Barry PH, Schofield PR (1993) Mol Pharmacol 44: 198-203
35. Vandenberg RJ, French CR, Barry PH, Schine J, Schofield PR (1992) Proc Natl Acad Sci USA 89: 1765-1769
36. Rajendra S, Vandenberg RJ, Pierce KD, Cunnigham AM, French PW, Barry PH, Schofield PR (1995) EMBO J 14: 2987-2998