Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 9, 1999, Pages 1556-1575

  Cappelli, Andrea ^a   Anzini, Maurizio ^b   Vomero, Salvatore ^a   Canullo, Laura ^a   Mennuni, Laura ^c   Makovec, Francesco ^c   Doucet, Edith ^d   Hamon, Michel ^d   Menziani, M Cristina ^e   De Benedetti, Pier G ^e   Bruni, Giancarlo ^a   Romeo, Maria R ^a   Giorgi, Gianluca ^a   Donati, Alessandro ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c Rotta Research Laboratorium   (Italy)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 METHYL 1 PIPERAZINYL)INDENO[1,2,3 DE]QUINOLINE; 4 (4 METHYLPIPERAZINYL)BENZOISOQUINOLINE; 5,6 DIHYDRO 4 (4 METHYL 1 PIPERAZINYL)BENZOISOQUINOLINE; 6 (4 METHYL 1 PIPERZINYL) 7,8,8A,9,10,11,12,12A OCTAHYDROBENZOPHENANTHRIDINE; 7,8 DIHYDRO 6 (4 METHYL 1 PIPERAZINYL)THIENO[2,3 K]PHENANTHRIDINE; GRANISETRON; GUANIDINE; N,N DIPROPYL 2 (4 METHYL 1 PIPERAZINYL)INDENO[1,2,3 DE]QUINOLINE 1 CARBOXAMIDE; PIPERAZINE DERIVATIVE; QUIPAZINE; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; RECEPTOR AFFINITY; SEROTONINERGIC SYSTEM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CELL LINE; GRANISETRON; LIGANDS; MALE; MICE; MODELS, MOLECULAR; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033529018     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981112s     Document Type: Article

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