A model of the nicotinic receptor extracellular domain based on sequence identity and residue location

Biophysical Journal

Volumn 73, Issue 1, 1997, Pages 52-66

  Tsigelny, Igor ^a   Sugiyama, Naova ^a,c   Sine, Steven M ^b   Taylor, Palmer ^a  

^a San Diego   (United States)

^b MAYO CLINIC   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; NICOTINIC RECEPTOR; PLASTOCYANIN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; GLYCOSYLATION; LIGAND BINDING; MOLECULAR DYNAMICS; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

EID: 0030957191     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78047-0     Document Type: Article

References (61)

1. Abramson, S. N., Y. Li, P. Culver, and P. Taylor. 1989. An analog of lophotoxin reacts covalently with tyrosine 190 in the α-subunit of the nicotinic acetylcholine receptor. J. Biol. Chem. 264:12666-12672.
2. Adman E. T., S. Turley, R. Bramson, K. Petratos, D. Banner, D. Tsernoglou, T. Beppu, and H. Watanabe. 1989. A 2.0-A structure of the blue copper protein (cupredoxin) from Alcaligenes faecalis S-6. J. Biol. Chem. 264:87-99.
3. Aylwin, M. L., and M. M. White. 1994. Gating properties of mutant acetylcholine receptors. Mol. Pharmacol. 46:1149-1155.
4. Beroukhim, R., and N. Unwin. 1995. Three-dimensional location of the main immunogenic region of the acetylcholine receptor. Neuron. 15: 323-331.
5. Blount, P., and J. P. Merlie. 1989. Molecular basis for the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor. Neuron. 3:349-357.
6. Changeux, J.-P. 1995. The acetylcholine receptor: a model for allosteric membrane proteins. Biochem. Soc. Trans. 23:195-205.
7. Chiara, D. C., and J. B. Cohen. 1992. Identification of amino acids contributine to high and low affinity d-tubocurarine (dTC) sites on the Torpedo nicotinic acetylcholine receptor (nAChR) subunits. Biophys. J. 61:A106.
8. Cockroft, V. B., G. G. Lunt, and D. J. Osguthorpe. 1990. Modeling of binding sites of nicotinic acetylcholine receptor and their relation to models of the whole receptor. Biochem. Soc. Symp. 57:65-79.
9. Codding, P. W., and M. N. G. James. 1973. The crystal and molecular structure of a potent neuromuscular blocking agent: d-tubocurarine dichloride pentahydrate. Acta Crystallogr. B. 29:935-942.
10. Cohen, J. B., S. D. Sharp, and W. S. Lin. 1991. Structure of the agonist-binding site of the nicotinic acetylcholine receptor. J. Biol Chem. 266: 23354-23364.
11. Corringer, P. J., J.-L. Galzi, J.-L. Eisele, S. Bertrand, J.-P. Changeux, and D. Bertrand. 1995. Identification of a new component of the agonist site of the nicotinic α7 homooligomeric receptor. J. Biol. Chem. 27: 11749-11752.
12. Czajkowski, C., and A. Karlin. 1991. Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. J. Biol. Chem. 266: 22603-22612.
13. Czajkowski, C., and A. Karlin. 1995. Structure of the nicotinic receptor acetylcholine-binding site. J. Biol. Chem. 1995:3160-3164.
14. Czajkowski, C., C. Kaufmann, and A. Karlin. 1993. Negatively charged amino acid residues in the nicotinic receptor δ subunit that contribute to the binding of acetylcholine. Proc. Natl. Acad. Sci. USA. 90:6285-6289.
15. Dennis, M., J. Giraudat, F. Kotzyba-Hibert, M. Goeldner, C. Hirth, J.-Y. Chang, C. Lazure, M. Chretien, and J.-P. Changeux. 1988. Amino acids of the Torpedo marmorata acetylcholine receptor α-subunit labeled by a photoaffinity ligand for the acetylcholine receptor by photoaffinity labeling. J. Biol. Chem. 265:10430-10437.
16. Doolittle, R. F. 1990. Searching through sequence databases. Methods Enzymol. 187:99-110.
17. Fitch, W. M. 1966. An improved method of testing for evolutionary homology. J. Mol. Biol. 16:9-16.
18. Fu, D.-X., and S. M. Sine. 1994. Competitive antagonists bridge the α-γ subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions. J. Biol. Chem. 269:26152-26157.
19. Galzi, J.-L., F. Revah, D. Black, M. Goeldner, C. Hirth, and J.-P. Changeux. 1990. Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. J. Biol. Chem. 265:10430-10437.
20. Gilson, M., and B. Honig. 1988. Calculations of electrostatic potentials in an enzyme active site. Proteins. 4:7-18.
21. Gu, Y., J. Forsayeth, S. Verall, X. Yu, and Z. Hall. 1991. Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells. J. Cell. Chem. 114:779-807.
22. Guddat, L. W., J. A. Martin, L. Shan, A. B. Edmundson, and W. R. Gray. 1996. Three-dimensional structure of a-conotoxin G1 at 1.2 Å resolution. Biochemistry. 35:11329-11335.
23. Guss, J. M., and H. C. Freeman. 1983. Structure of oxidized poplar plastocyanin at 1.6 Å resolution. J. Mol. Biol. 169:521-563.
24. Hultner, M., D. W. Smith, and C. Wills. 1994. Similarity landscapes: a way to detect many structural and sequence motifs in both introns and exons. J. Mol. Evol. 38:188-203.
25. Kao, P. N., A. J. Dwork, R. J. Kaldany, M. L. Silver, J. Wideman, S. Stein, and A. Karlin. 1984. Identification of the α subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site. J. Biol. Chem. 259:11662-11665.
26. Karlin, A., and M. H. Akabas. 1995. Towards a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231-1244.
27. Keller, S. H., H.-J. Kreienkamp. C. Kawanishi, and P. Taylor. 1995. Molecular determinants conferring alpha toxin resistance in recombinant DNA-derived acetylcholine receptors. J. Biol. Chem. 270:4165-4171.
28. Kraulis, P. J. 1991. MOLSCRIPT: a program to produce both detailed and chematic plots of protein structures. J. Appl. Crystallogr. 24:946-950.
29. Kreienkamp, H.-J., R. K. Maeda, S. M. Sine, and P. Taylor. 1995. Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron. 14: 635-644.
30. Machold, J., C. Weise, Y. Utkin, V. Tsetlin, and F. Hucho. 1995. The handedness of the subunit arrangement of the nicotinic acetylcholine receptor from Torpedo californica. Eur. J. Biochern. 234:427-430.
31. Messerschmidt, A., and R. Huber. 1990. The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modeling and structural relationships. Eur. J. Biochem. 187:341-352.
32. Middleton, R. E., and J. B. Cohen. 1991. Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label. Biochemistry. 30:6987-6997.
33. Myers, R. A., G. C. Zafaralla, W. R. Gray, J. Abbott, L. J. Cruz, and B. M. Olivera. 1991. α-Conotoxins, small peptide probes of nicotinic acetylcholine receptors. Biochemistry. 30:9370-9377.
34. Novere, N. L., and J.-P. Changeux. 1995. Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J. Mol. Evol. 40:155-172.
35. Nowak, M. W., P. C. Kearney, J. R. Sampson, M. E. Saks, C. G. Labarca, S. K. Silverman, W. Zhong, J. Thorson, J. N. Abelson, N. Davidson, P. G. Schultz, D. A. Dougherty, and H. A. Lester. 1995. Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells. Science. 268:439-442.
36. Nunzi, F., M. Woudstra, D. Campese, J. Bonicell, D. Morin, and M. Bruschi. 1993. Amino-acid sequence of rusticyanin from Thiobacillus ferrooxidans, and its comparison with other blue copper proteins. Biochim. Biophys. Acta. 1162:28-34.
37. O'Hara, P., P. O. Sheppard, H. Thorgersen, D. Venezia, B. A. Haldeman, V. McGrane, K. H. Houamed, C. Thomsen, T. C. Gilbert, and E. R. Mulvihill. 1993. The ligand binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:41-52.
38. Ohno, K., H. L. Wang, M. Milone, N. Bren, J. Brengman, S. Nakano, P. Quiram, J. Pruitt, S. M. Sine, and A. Engel. 1996. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to mutation in acetylcholine receptor ∈-subunit. Neuron. 17:157-170.
39. O'Leary, M. E., and M. M. White. 1992. Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor. J. Biol. Chem. 267:8360-8365.
40. O'Leary, M. E., G. N. Filatov, and M. M. White. 1994. Characterization of the d-tubocurarine binding site of Torpedo acetylcholine receptor. Am. J. Physiol. 266:C948-C653.
41. Oswald, R. E., and J.-P. Changeux. 1982. Cross-linking of a-bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation. FEBS Lett. 139:225-229.
42. Pearson, W. R. 1990. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol. 183:63-98.
43. Pearson, W. R. 1996. Effective protein sequence comparison. Methods Enzymol. 266:227-258.
44. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA. 85:2444-2448.
45. Prince, R. J., and S. M. Sine. 1996. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine agonist selectivity. J. Biol Chem. 42:25770-25777.
46. Ryden, L. G., and L. T. Hunt. 1993. Evolution of protein complexity: the blue copper-containing oxidases and related proteins. J. Mol. Evol. 36: 41-66.
47. Sine, S. M. 1993. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity. Proc. Natl. Acad. Sci. USA. 90:9436-9440.
48. Sine, S. M., and T. Claudio. 1991. Gamma-and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor. J. Biol. Chem. 266:19369-19377.
49. Sine, S. M., H.-J. Kreienkamp, N. Bren, R. Maeda, and P. Taylor. 1995. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of α-conotoxin M1 selectivity. Neuron. 15:205-211.
50. Sine, S. M., P. Quiram, F. Papanicolau, H.-J. Kreienkamp, and P. Taylor. 1994. Conserved tyrosines in the α subunit of the nicotinic acetylcholine receptor stabilize quarternary ammonium groups of agonists and curariform antagonists. J. Biol. Chem. 269:8808-8816.
51. Stern-Bach, Y., B. Bettler, M. Hartley, P. O. Sheppard, P. J. O'Hara, and S. F. Heinemann. 1994. Agonist selectivity of the glutamate receptor specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron. 13:1345-1357.
52. Sugiyama, N., A. E. Boyd, and P. Taylor. 1996. Anionic residue in the α-subunit of the nicotinic acetylcholine receptor contributing to subunit assembly and ligand binding. J. Biol. Chem. 271:26575-26581.
53. Sutcliffe, M. J., Z. G. Wo, and R. E. Oswald. 1996. Three-dimensional models of non-NMDA glutamate receptors. Biophys. J. 70:1575-1589.
54. Tomaselli, G. F., J. T. McLaughlin, M. E. Jurman, E. Hawrot, and G. Yellen. 1991. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys. J. 60:721-727.
55. Tremeau, O., C. Lemaire, P. Drevet, S. Pinkasfeld, F. Ducancel, J. C. Boulain, and A. Menez. 1995. Genetic engineering of snake toxins. The functional site of Erabutoxin α, as delineated by site-directed mutagenesis, includes variant residues. J. Biol. Chem. 270:9362-9369.
56. Tzartos, S. J., A. Kokla, S. L. Walgrave, and B. M. Conti-Tronconi. 1988. Localization of the main immunogenic region of human muscle acetylcholine receptor to residues 67-76 of the a-subunit. J. Neuroimmunol. 15:185-194.
57. Unwin, N. 1993. Nicotinic acetylcholine receptor at 9 Å resolution. J. Mol. Biol. 229:1101-1124.
58. Unwin, N. 1995. Acetylcholine receptor imaged in the open state. Nature. 373:37-43.
59. Unwin, N. 1996. Projection structure of nicotinic acetylcholine receptor: distinct conformations of the α subunits. J. Mol. Biol. 257:586-596.
60. Weiner, S. J., P. A. Kollman, D. Case, U. C. Singh, C. Ohio, G. Alagona, S. Profeta, Jr., and P. Weiner. 1984. A new force field for molecular mechanical simulation of nucleic acids and proteins. J. Am. Chem. Soc. 106:765-784.
61. Wo, Z G., and R. E. Oswald. 1994. Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation. Proc. Natl. Acad. Sci USA. 91:7154-7158.