Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus

Hybridoma

Volumn 20, Issue 1, 2001, Pages 1-10

  Long, Melissa C ^a   Marshall, Kelly E J ^a   Kearney, Brian J ^a   Ludwig, George V ^a   Wong, Jonathan P ^a   Nagata, Les P ^a  

^a Station Main   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; EPITOPE; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; CHIMERA; CONTROLLED STUDY; CROSS REACTION; DRUG BINDING; DRUG DISTRIBUTION; ENCAPSULATION; ENCEPHALITIS; FEMALE; IMMUNOTHERAPY; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SINDBIS VIRUS; TISSUE DISTRIBUTION; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; WESTERN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS;

ADMINISTRATION, INTRANASAL; ALPHAVIRUS; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY SPECIFICITY; CROSS REACTIONS; DRUG COMPOUNDING; ENCEPHALITIS VIRUS, WESTERN EQUINE; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; INJECTIONS, INTRAMUSCULAR; LIPOSOMES; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; RECOMBINANT FUSION PROTEINS; TISSUE DISTRIBUTION;

ALPHAVIRUS; ANIMALIA; EQUIDAE; RNA VIRUSES; SINDBIS VIRUS; VENEZUELAN EQUINE ENCEPHALITIS VIRUS; WESTERN EQUINE ENCEPHALOMYELITIS VIRUS;

EID: 0035574455     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/027245701300060328     Document Type: Article

References (50)

1. The alphaviruses: Gene expression, replication, and evolution
2. Budding of alphaviruses
3. Togaviridae: The viruses and their replication
4. Alphaviruses
5. Determination of the protective epitopes on the glycoproteins of Venezuelan equine encephalomyelitis virus by passive transfer of monoclonal antbodies
6. Properties of monospecific antibodies to the glyco-protein of western equine encephalitis virus
7. Biochemical and biological characteristics of epitopes on the E1 glycoprotein of western equine encephalitis virus
8. 2 glycoprotein of semliki forest virus can protect mice from lethal encephalitis
9. The role of antibody in recovery from alphavirus encephalitis
10. Control of Sindbis virus infection by antibody in interferon-deficient mice
11. Man-made antibodies
12. Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli
13. A single chain antibody fragment expressed in bacteria neutralizes tick-borne flaviviruses
14. Cloning and expression of a single-chain antibody fragment specific for foot-and-mouth disease virus
15. A recombinant single chain antibody neutralizes coronavirus infectivity but only slightly delays lethal infection of mice
16. Cloning, expression and functional activities of a single chain antibody fragment directed to fusion protein of respiratory syncytial virus
17. Phage-displayed and soluble mouse scFv fragments neutralize rabies virus
18. Sequence analysis of a monoclonal antibody specific for the preS2 region of hepatitis B surface antigen, and the cloning, expression and characterisation of its single-chain Fv construction
19. High cytoplasmic expression in E. coli, purification, and in vitro refolding of a single chain Fv antibody fragment against the hepatitis B surface antigen
20. Human recombinant single-chain antibody fragments, specific for the hypervariable region 1 of hepatitis C virus, from immune phage-display libraries
21. Generation and characterization of a single chain Fv specific against western equine encephalitis virus
22. Development of a functional monoclonal single-chain variable fragment antibody against Venezuelan equine encephalitis virus
23. Construction and characterization of monoclonal antibodies against western equine encephalitis virus
24. Construction and characterization of a novel recombinant single chain variable fragment antibody against western equine encephalitis virus
25. Genetically engineered antibodies
26. Analysis of viral antigens using biosensor technology
27. A putative receptor for Venezuelan equine encephalitis virus from mosquito cells
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. A simple procedure for preparing liposomes capable of high efficiency under mild conditions
30. Enhanced protection against respiratory influenza A infection in mice by liposome-encapsulated antibody
31. Humanization of murine monoclonal antibodies through viable domain resurfacing
32. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
33. Human recombinant single-chain antibody fragments, specific for the hypervariable region 1 of hepatitis C virus, from immune phage-display libraries
34. Binding affinity and inhibitory properties of a single-chain anti-T cell receptor antibody
35. Characterization of a recombinant single-chain molecule comprising the variable domains of a monoclonal antibody specific for human fibrin fragment D-dimer
36. Cloning and expression of a single-chain Fv fragment specific for the human interleukin 18 receptor
37. Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries
38. Expression in Escherichia coli of soluble and M13 phage-displayed forms of a single-chain antibody fragment specific for digoxin: Assessment in a novel drug immunoassay
39. Production and in vitro refolding of a single-chain antibody specific for human plasma apolipoprotein A-I
40. 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts
41. Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library
42. Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries
43. The role of antibody concentration and avidity in antiviral protection
44. Determination of the binding affinity of an anti-CD34 single-chain antibody using a novel, flow cytometry based assay
45. Immunological responses to nasal delivery of free and encapsulated tetanus toxoid: Studies on the effect of vehicle volume
46. Biodistribution study of a monoclonal antibody specific to link proteins from human cartilage
47. Pharmacokinetics of reshaped Mab425 in three animal species
48. Effects of genetic engineering on the pharmacokinetics of antibodies
49. 131I-VIP in rat using gamma camera