MALDI TOF mass spectrometry: An emerging platform for genomics and diagnostics

Expert Review of Molecular Diagnostics

Volumn 1, Issue 1, 2001, Pages 11-18

  Leushner, James ^a  

^a SEQUENOM INC   (United States)

Author keywords

Diagnostics; Genomics; Haplotyping; MALDI MS; MassArray; MassExtend; Pharmacogenomics; SNP; SpectroChip; SpectroDesign

Indexed keywords

DIAGNOSTIC ACCURACY; GENOMICS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEIC ACID STRUCTURE; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REVIEW;

EID: 0035557687     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737159.1.1.11     Document Type: Review

References (38)

1. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
2. Mass spectrometry of nucleic acids: The promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry
3. The new time-of-flight mass spectrometry
4. Chip-based genotyping by mass spectrometry
5. MALDI on a chip analysis of arrays of low-to subfemtomole quantities of synthetic oligonucleotides and DNA diagnostic products dispensed by piezoelectric pipette
6. Genotyping by mass spectrometric analysis of Short DNA fragments
7. Pharmacogenetics becomes pharmacogenomics: Wake up and get ready
8. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
9. A simple method for analysing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies
10. Quantitative approach to single-nucleotide polymorphism analysis using MALDI-TOF mass spectrometry
11. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I.DNA pooling
12. Association mapping of disease loci, by use of a pooled DNA genomic screen
13. Determining SNP allele frequencies in DNA pools
14. Light-directed, spatially addressable parallel chemical synthesis
15. Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models
16. Molecular interactions on microarrays
17. DNA analysis and diagnostics on oligonucleotide microchips
18. Microarray-based detection of select cardiovascular disease markers
19. DNA microarrays in drug discovery and development
20. Using oligonucleotide probe arrays to access genetic diversity
21. Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control
22. Integrated microchip device with electrokinetically controlled solvent mixing for isocratic and gradient elution in micellar electrokinetic chromatography
23. Chip PCR. II. Investigation of different PCR amplification systems in microfabricated silicon-glass chips
24. High density, covalent attachment of DNA to silicon wafers for analysis by MALDI-TOF mass spectrometry
25. Mass spectrometry from miniaturized arrays for full comparative DNA analysis
26. Electrospray deposition as a method for mass fabrication of mono- and multicomponent microarrays of biological and biologically active substances
27. Universal DNA microarray method for multiplex detection of low abundance point mutations
28. Making and reading microarrays
29. Improved analysis of microsatellites using mass spectrometry
30. International human genome sequencing consortium. Initial sequencing and analysis of the human genome
31. The sequence of the human genome
32. Single-nucleotide polymorphism identification assays using a thermostable DNA polymerase and delayed extraction MALD-TOF mass spectrometry
33. High-throughput SNP gentyping with Masscode system
34. Notes from the SNP vs. haplotype front
35. The relative power of SNPs and haplotype as genetic markers for association tests
36. A strategy for rapid and efficient DNA sequencing by mass spectrometry
37. Sequencing exons 5 to 8 of the p53 gene by MALD-TOF mass spectrometry
38. Infrared MALDI mass spectrometry of large nucleic acids