Effect of capsaicin on voltage-gated currents of trigeminal neurones in cell culture and slice preparations

Acta Physiologica Hungarica

Volumn 88, Issue 3-4, 2001, Pages 173-196

  Balla, Zs ^a   Szoke, Éva ^a   Czeh G ^a   Szolcsányi, János ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Cationic currents; Nerve growth factor (NGF); Nociceptive neurones; Sensory desensitization; Vanilloid (VR1) receptors; Whole cell patch clamp

Indexed keywords

CAPSAICIN; CATION; DRUG RECEPTOR; LOCAL ANESTHETIC AGENT; NERVE GROWTH FACTOR; POTASSIUM; TETRODOTOXIN;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; METABOLISM; NOCICEPTIVE RECEPTOR; ORGAN CULTURE TECHNIQUE; PATCH CLAMP; PHYSIOLOGY; RAT; SENSORY NERVE CELL; STIMULATION; TRIGEMINUS GANGLION; WISTAR RAT;

ANESTHETICS, LOCAL; ANIMALS; CAPSAICIN; CATIONS; CELLS, CULTURED; MEMBRANE POTENTIALS; NERVE GROWTH FACTOR; NEURONS, AFFERENT; NOCICEPTORS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; POTASSIUM; RATS; RATS, WISTAR; RECEPTORS, DRUG; STIMULATION, CHEMICAL; TETRODOTOXIN; TRIGEMINAL GANGLION;

EID: 0035552271     PISSN: 0231424X     EISSN: None     Source Type: Journal    
DOI: 10.1556/APhysiol.88.2001.3-4.1     Document Type: Article

References (52)

1. Baccaglini PI, Hogan PG: Some rat sensory neurones in culture express characteristics of differentiated pain sensory cells. Proc. Natl. Acad. Sci. (USA) 80, 594-598 (1983)
2. Baumann KT, Burchiel KJ, Ingram SL, Martenson ME: Responses of adult human dorsal root ganglion neurones in culture to capsaicin and low pH. Pain 65, 31-38 (1996)
3. Bevan S (1996): Intracellular messengers and signal transduction in nociceptors. In Neurobiology of Nociceptors (eds. Belmonte C. and Cervero F.). Oxford Univ. Press, Oxford. pp. 298-324
4. Bevan S, James JF, Rang HP, Winter J (1987): The mechanism of action of capsaicin: A sensory neurotoxin. In Neurotoxins and their Pharmacological Implications (ed. Jenner P.). Raven Press, New York, pp. 261-277
5. Bevan S, Docherty RJ (1993): Cellular mechanisms of the action of capsaicin. In Capsaicin in the Study of Pain (ed. Wood JN.). Academic Press, London, pp. 27-44
6. Bevan S, Docherty RJ (1996): The ionic basis of capsaicin-evoked responses. In Neurogenic Inflammation (eds. Gepetti P. and Holzer P.). CRC Press, pp. 53-67
7. Bevan S, Szolcsányi J: Sensory neuron specific actions of capsaicin: mechanisms and applications. Trends Pharmac. Sci. 11, 330-333 (1990)
8. Bleakman D, Brorson JR, Miller RJ: The effects of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells. Br. J. Pharmacol. 101, 423-431 (1990)
9. Caffrey JM, Eng DL, Black JA, Waxman SD, Kocsis JD: Three types of sodium channels in adult rat dorsal root ganglion neurones. Brain Res. 592, 283-297 (1992)
10. 2+ ions in chick sensory neurones. J. Physiol. (London) 504, 1-15 (1997)
11. Cardenas CG, Del Mar LP, Scroggs RS: Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurones differentiated by membrane properties. J. Neurophysiol. 74, 1870-1879 (1995)
12. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D: The capsaicin receptor: a heat-activated ion channels in the pain pathway. Nature 389, 816-824 (1997)
13. Cholewinski A, Burgess GM, Bevan S: The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurones. Neuroscience 55, 1015-1023 (1993)
14. Docherty RJ, Robertson B, Bevan S: Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurones in culture. Neuroscience 40, 513-521 (1991)
15. Elliott AA, Elliott JR: Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (Lond.) 463, 39-56 (1993)
16. Heyman I, Rang HP: Depolarizing responses to capsaicin in a subpopulation of rat dorsal root ganglion cells. Neuroscience Letters 56, 69-75 (1985)
17. Hille B: Ion Channels of Excitable Membranes. Sinauer, Sunderland, MA (1992)
18. Holzer P: Capsaicin: cellular targets, mechanisms of action, and selectivity for thin neurones. Pharmacol. Rev 43, 143-201 (1991)
19. Koplas PA, Rosenberg RL, Oxford GS: The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurones. J. Neuroscience 17, 3525-3537 (1997)
20. Liu L, Simon SA: A rapid capsaicin-activated current in rat trigeminal ganglion neurones. Proc. Natl. Acad. Sci. (USA) 91, 738-741 (1994)
21. Liu L, Simon SA: Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. J. Neurophysiol. 76, 1858-1869 (1996)
22. 2+ dependence in rat trigeminal ganglion cells. J. Neurophysiol. 75, 1503-1514 (1996)
23. Liu L, Wang Y, Simon SA: Capsaicin-activated currents in rat dorsal root ganglion cells. Pain 64, 191-195 (1996)
24. Liu L, Oortgiesen M, Li L, Simon SA: Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons. J. Neurophysiol. 85, 745-58 (2001)
25. Marsh SJ, Stansfeld CE, Brown DA, Davey R, McCarthy D: The mechanism of action of capsaicin on sensory C-type neurones and their axons in vitro. Neuroscience 23, 275-289 (1987)
26. Mendell LM (1996): Development of the nociceptor phenotype: role of nerve growth factor. In Neurobiology of Nociceptors (eds. Belmonte C. and Cervero F.). Oxford Univ. Press. Oxford, pp. 455-472
27. Nagy I, Rang H: Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurones. Neuroscience 88, 995-997 (1999)
28. Oh U, Hwang SW, Kim D: Capsaicin activates a nonselective cation channels in cultured neonatal rat dorsal root ganglion neurones. J. Neurosci. 16, 1659-1667 (1996)
29. Petersen M, La Motte RH: Relationships between capsaicin sensitivity of mammalian sensory neurones, cell size and type of voltage gated Ca-currents. Brain Res. 561, 20-26 (1991)
30. Piper AS, Yeats JC, Bevan S, Docherty RJ: A study of the voltage dependence of capsaicin-activated membrane currents in rat sensory neurones before and after acute desensitization. J. Physiol. (London) 518, 721-733 (1999)
31. Rush AM, Brau ME, Elliott AA, Elliott JR: Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. J. Physiol. (London) 511, 771-789 (1998)
32. Rusin KI, Moises HC: μ-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurones. J. Neurosci 15, 4315-4327 (1995)
33. Safronov BV, Vogel W: Properties and functions of Na-activated K channels in the soma of rat motoneurones. J. Physiol. 497, 3, 727-734 (1996)
34. + channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation. J. Physiol. (London) 513, 55-69 (1998)
35. Scroggs RS, Fox AP: Calcium current variation between acutely isolated adult rat dorsal root ganglion neurones of different size. J. Physiol. (Lond) 445, 639-658 (1992)
36. Seno N, Dray A: Capsaicin-induced activation of fine afferent fibres from rat skin in vitro. Neuroscience 55, 563-569 (1993)
37. Shen KF, Crain SM: Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurones in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells. J. Neurosci. 14, 5570-5579 (1994)
38. Shu X-Q, Mendell L: Neurotrophin effects on capsaicin-induced inward currents of sensory neurones in the rat. Abstr. Soc. Neurosci, No. 319.10 (1998)
39. Szállási A, Blumberg PM: Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci. 47, 139-148 (1990)
40. Szállási A, Blumberg PM: Vanilloid (capsaicin) receptors and mechanisms. Pharmacological Rev. 51, 159-211 (1999)
41. Szolcsányi J: A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J. Physiol. (Paris) 73, 251-259 (1977)
42. Szolcsányi J: Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin, and ultraviolet irradiation. J. Physiol. 338, 9-23 (1987)
43. Szolcsányi J (1990): Capsaicin, irradiation and desensitization: neurophysiological basis and future perspectives. In Chemical Senses, Vol. 2: Irradiation (eds. Green B. G., Mason J. R. and Kare M. R.). Marcel Dekker, Inc. New York, pp. 141-169
44. Szolcsányi J (1993): Actions of capsaicin on sensory receptors. In: Capsaicin in the Study of Pain (ed. Wood JN.). Academic Press, London, pp. 1-26
45. Szolcsányi J, Anton F, Reeh PW, Handwerker HO: Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res. 446, 262-268 (1988)
46. Szolcsányi J, Jancsó-Gábor A: Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain producing potency of pungent agents. Arzneim.-Forsch. (Drug Res.) 25, 1877-1881 (1975)
47. Szoke É, Balla Zs, Csernoch L, Czéh G, Szolcsányi J: Interacting effects of capsaicin and anandamide on intracellular calcium in sensory neurones. Neuroreport 11, 1949-52 (2000)
48. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Baumann BE, Basbaum AI, Julius D: The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531-543 (1998)
49. Vlachová V, Vyklicky L: Capsaicin-induced membrane currents in cultured sensory neurones of the rat. Physiol. Res. 42, 301-311 (1993)
50. Vyklicky L, Knotkova-Urbancova H, Vitaskova Z, Vlachova V, Kress M, Reeh PW: Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurones from newborn rats. J. Neurophysiol. 79, 670-676 (1998)
51. Winter J, Forbes CA, Sternberg J, Lindsay RM: Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin. Neuron 1, 973-981 (1988)
52. Wood JN, Docherty R: Chemical activators of sensory neurones. Annu. Rev. Physiol. 59, 457-482 (1997)