A proliferation control network model: The simulation of two-dimensional epithelial homeostasis

Acta Biotheoretica

Volumn 49, Issue 4, 2001, Pages 219-234

  Morel, Didier ^a   Marcelpoil, Raphaël ^b   Brugal, Gérard ^a  

^a LABORATOIRE TIMC IMAG   (France)

^b BuroClub   (France)

Author keywords

Cell cycle; Cell proliferation; Computer simulation; Homeostasis; Model; Stratified epithelium

Indexed keywords

CYTOLOGY; HOMEOSTASIS;

ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL MOTION; COMPUTER SIMULATION; CYTOLOGY; EPITHELIUM CELL; FEEDBACK SYSTEM; HOMEOSTASIS; HUMAN; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; COMPUTER SIMULATION; EPITHELIAL CELLS; FEEDBACK, BIOCHEMICAL; HOMEOSTASIS; HUMANS; SIGNAL TRANSDUCTION;

EID: 0035544043     PISSN: 00015342     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014201805222     Document Type: Article

References (55)

1. Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints
2. The kinetic origins of the restriction point in the mammalian cell cycle
3. Three clonal types of keratinocyte with different capacities for multiplication
4. Emergent properties of networks of biological signaling pathways
5. A dynamic model of tissue growth and cell patterning
6. Cell sociology and the problem of position effect: Pattern formation, origin and role of gradients
7. A three-dimensional dynamic simulation model of epithelial tissue renewal
8. Modeling and simulation of growing spheroids
9. Dynamics of open chemical systems and the algebraic structure of the underlying reaction network
10. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
11. The mathematical modelling of cell kinetics in corneal epithelial wound healing
12. A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase
13. Differences in human skin between the epidermal growth factor receptor distribution detected by EGF binding and monoclonal antibody recognition
14. A mathematical description of regulation of the G1-S transition of the mammalian cell cycle
15. Description of cellular patterns by Dirichlet domains : The two-dimensional case
16. A computer simulation of geometrical configurations during cell division
17. Establishment of epidermal cell columns in mammalian skin: Computer simulation
18. Spontaneous architectural organization of mammalian epidermis from random cell packing
19. Studies and perspectives of signal transduction in the skin
20. Cell cycle regulators in the keratinocyte (cyclin-cdk)
21. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: A new view based on whole mount labelling and lineage analysis
22. Epithelial stem cells
23. Integrin expression in normal, hyperplastic, dysplastic and malignant oral epithelium
24. The macroworld versus the microworld of biochemical regulation and control
25. Quantification of short term signaling by the epidermal growth factor receptor
26. Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phas transition
27. Molecular interaction map of the mammalian cell cycle control and DNA repair systems
28. Construction of a generalized simulator for multi-cellular organisms and its application to SMAD signal transduction
29. Epidermal stem cells
30. Epidermal stem cells: Properties, markers and location
31. Startegies of epithelial repair: Modulation of stem cell and transit amplifying cell proliferation
32. Stimulation of human epidermal differentiation by Delta-Notch signalling at the boundaries of stem-cell clusters
33. Methods for the study of cellular sociology: Voronoï diagrams and parametrization of the spatial relationships
34. Biochemistry by numbers: Simulation of biochemical pathways with Gepasi 3
35. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion
36. Modeling the cell division cycle: M-phase trigger, oscillations, and size control
37. A mathematical model of the G1 phase of Rb+/+ and Rb -/- Mouse embryonic fibroblasts and an osteosarcoma cell line
38. Mechanical aspects of mesenchymal morphogenesis
39. A restriction point for control of normal animal cell proliferation
40. Protein modules and signalling networks
41. Signaling networks - Do all roads lead to the same genes
42. Epithelial stem cells in vivo
43. The use of a computer model to simulate epithelial pathologies
44. The virtual cell
45. Cell cycle models for molecular biology and molecular oncology: Exploring new dimensions
46. CDK inhibitors: Positive and negative regulators of G1-phase progression
47. A computer graphic simulation of squamous epithelium
48. Involvment of follicular stem cells in forming not only the follicle but also the epidermis
49. E-Cell: Software environment for whole cell simulation
50. Epidermal stem cells: Markers, patterning and the control of stem cell fate. Philosophical transactions of the Royal Society of London
51. Out of Eden: Stem cells and their niches