Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells

Anticancer Research

Volumn 21, Issue 5, 2001, Pages 3261-3268

  Shinoura, Nobusada ^a   Furitsu, Takuma ^a   Asai, Akio ^a   Kirino, Takaaki ^a   Hamada, Hirofumi ^a  

^a TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

Author keywords

Apoptosis; Caspase 8; Fas ligand; Glioma; p27Kip1

Indexed keywords

ADENOVIRUS VECTOR; BETA ACTIN; CASPASE 8; FAS ANTIGEN; FAS LIGAND; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P27; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 9; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; GENETIC TRANSDUCTION; GLIOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; ADENOVIRUS; BIOSYNTHESIS; CELL CULTURE; GENE VECTOR; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADENOVIRIDAE; APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FAS LIGAND PROTEIN; GENETIC VECTORS; GLIOMA; HUMANS; MEMBRANE GLYCOPROTEINS; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035528850     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
2. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
3. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
4. Kip1-deficient mice
5. Kip1
6. Kipl and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
7. Kip1 protein: Prognostic implications in primary breast cancer
8. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
9. Kip1 in multistage colorectal carcinogenesis
10. Loss of altered subcellular localization of p27 in Barrett's associated adenocarcinoma
11. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
12. Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
13. Kip1 in malignant melanoma: Inverse correlation with diseasefree survival
14. Kip1 expression in human astrocytic gliomas
15. Analysis of cyclin-dependent kinase inhibitors in malignant astrocytomas
16. E-gadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)
17. Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases
18. Involvement of the bcl-2 gene in human follicular lymphoma
19. Cooperative interaction between c-myc and bcl-2 proto-oncogenes
20. Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis
21. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
22. p53-dependent apoptosis suppresses tumor growth and progression in vivo
23. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells
24. Expression of Fas/APO-1 during progression of astrocytomas
25. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
26. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
27. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
28. Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells: Implications for gene therapy
29. Adenovirus-mediated transfer of caspase-8 in combination with super-repressor of NF-πB drastically induced apoptosis in gliomas
30. Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal
31. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
32. Promoting apoptosis: A novel activity associated with the cyclin-dependent kinase inhibitor p27
33. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
34. The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells
35. Genetic determinants of p53-induced apoptosis and growth arrest
36. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
37. Altered cell differentiation and proliferation in mice lacking p57Klip2 indicates a role in Beckwith-Wiedemann syndrome
38. Kip1
39. Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
40. Apoptosis and the cell cycle
41. Selective expression of foreign genes in glioma cells: Use of the mouse myelin basic protein gene promoter to direct toxic gene expression
42. Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: Myelin basic protein promoter is strongly active in human malignant gliomas
43. Highly augmented cytopathic effect of a fiber-mutant E1 B-defective adenovirus for gene therapy of gliomas
44. Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma