A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor

Journal of Experimental Medicine

Volumn 194, Issue 7, 2001, Pages 883-891

  Sasada, T ^a   Ghendler, Y ^a   Neveu, J M ^a   Lane, W S ^a   Reinherz, E L ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

CTL; Naturally processed peptides; Positive selection; TAP 1 ; Thymocyte development

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOCHONDRIAL SELF PEPTIDE; PEPTIDE; PEPTIDE FRAGMENT; RECOMBINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRION; MOUSE; NONHUMAN; ORGAN CULTURE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; THYMOCYTE; THYMUS; TRANSGENE; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTIGEN PRESENTATION; ELECTRON TRANSPORT COMPLEX I; H-2 ANTIGENS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SELECTION (GENETICS); THYMUS GLAND; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0035477792     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.7.883     Document Type: Article

References (44)

1. T cell antigen receptor genes and T cell recognition
2. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
3. In a radiation chimera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
4. Positive selection of T cells
5. Positive selection of thymocytes
6. Positive selection of lymphocytes
7. On the thymus in the differentiation of" H-2 self-recognition" by T cells: Evidence for dual recognition
8. Negative selection of lymphocytes
9. The effects of MHC gene dosage and allelic variation on T cell receptor selection
10. Role of self-peptides in positively selecting the T cell repertoire
11. b mutations that involve peptide binding
12. + T cells induced by major histocompatibility complex binding peptide in fetal thymic organ culture
13. + T cells
14. + T cells
15. The role of β2-microglobulin in peptide binding by class I molecule
16. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands
17. Identification of a naturally occurring ligand for thymic positive selection
18. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes
19. + T lymphocytes in the thymus
20. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide
21. T cell receptor antagonist peptides induce positive selection
22. + T cells
23. Evidence for a differential avidity model of T cell selection in the thymus
24. Positive and negative thymocyte selection induced by different concentrations of a single peptide
25. T-cell-receptor affinity and thymocyte positive selection
26. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex
27. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity
28. high thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection
29. The structure of the antigen-binding groove of major histocompatibility complex class I molecules determines specific selection of self-peptides
30. Rabbit β-globin is extended beyond its UGA stop codon by multiple suppressions and translational reading gaps
31. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
32. T cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection
33. Empty MHC class I molecules come out in the cold
34. Direct analysis of protein complexes using mass spectrometry
35. Sequence of 20 subunits of NADH: Ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction
36. Comparison of peptides bound to spleen and thymus class II
37. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide
38. k peptide combination
39. + T cells
40. 0/0 mice
41. Structural basis of T cell recognition
42. The crystal structure of a T cell receptor in complex with peptide and MHC class II
43. Structural basis of cell-cell interactions in the immune system
44. Are MHC-bound peptides a nuisance for positive selection?