The Gut and Food Intake: An Update for Surgeons

Journal of Gastrointestinal Surgery

Volumn 5, Issue 5, 2001, Pages 556-567

  Näslund, Erik ^a   Hellström, Per M ^b   Kral, John G ^c  

^a DANDERYD HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Appetite regulation; Cholecystokinin; Gastrointestinal surgery; Glucagon like peptide 1; Neurogastroenterology; Vagus nerve

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CARRIER PROTEIN; CHOLECYSTOKININ; GASTROINTESTINAL HORMONE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; LEPTIN; NEUROPEPTIDE; OREXINS; PEPTIDE; PEPTIDE FRAGMENT; PROTEIN PRECURSOR; SIGNAL PEPTIDE;

EATING; FOOD INTAKE; HUMAN; INNERVATION; INTESTINE; MORBID OBESITY; PHYSIOLOGY; REVIEW; SURGERY;

APPETITE REGULATION; CARRIER PROTEINS; CHOLECYSTOKININ; EATING; GASTROINTESTINAL HORMONES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; HUMANS; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; OBESITY, MORBID; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN PRECURSORS; SURGICAL PROCEDURES, OPERATIVE;

EID: 0035468806     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(01)80095-0     Document Type: Article

References (148)

1. Wood JD, Alpers DH, Andrews PL. Fundamentals of neurogastroenterology. Gut 1999;45(Suppl 2):II6-I116.
2. Kirchgessner AL, Liu M. Orexin synthesis and response in the gut. Neuron 1999;24:941-951.
3. Jin SLC, Han VKM, Simmons JG, Towle AC, Lauder JM, Lund PK. Distribution of glucagonlike peptide-I (GLP-I), glucagon, and glicentin in the rat brain: An immunocytochemical study. J Comp Neurol 1988;271:519-532.
4. Geiselman PJ. Control of food intake. A physiologically complex, motivated behavioral system. Endocrinol Metab Clin North Am 1996;25:815-829.
5. Tang-Christensen M, Larsen PJ, Thulesen J, Rømer J, Vrang N. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat Med 2000;6:802-807.
6. Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Müller-Weiland D, Kahn RC. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
7. Pheng LH, Regoli D. Receptors for NPY in peripheral tissues bioassays. Life Sci 2000;67:847-862.
8. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight Endocr Rev 1999;20:68-100.
9. Blundell JE, Lawton CL, Hill AJ. Mechanisms of appetite control and their abnormalities in obese patients. Horm Res 1993;39(Suppl 3):72-76.
10. Smith GP, Gibbs J. The effect of gut peptides on hunger, satiety, and food intake in man. Ann NY Acad Sci 1997;499: 132-136.
11. Mei N, Lucchini S. Current data and ideas on digestive sensitivity. J Auton Nerv Sys 1992;41:15-18.
12. Read NW. Feedback regulation and sensation. Dig Dis Sci 1994;39(12 Suppl):37S-40S.
13. Heatherington MM. In what way is eating disordered in the eating disorders. Int Rev Psych 1993;5:33-50.
14. Tataranni PA, Gautier JF, Chen K, Uecker A, Bandy D, Salbe AD, Pratley RE, Lawson ML, Reiman EM, Ravussin E. Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc Nad Acad Sci USA 1999;96:4569-4574.
15. Friedman JM. Obesity in the new millennium. Nature 2000; 404:632-634.
16. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ. The stomach is a source of leptin. Nature 1998;394:790-793.
17. McHugh PR, Moran TH. Calories and gastric emptying: A regulatory capacity with implications for feeding. Am J Physiol 1979;236:R254-R260.
18. Horowitz M, Jones K, Edelbroek MA, Smout AJ, Read NW. The effect of posture on gastric emptying and intragastric distribution of oil and aqueous meal components and appetite. Gastroenterology 1993;105:382-390.
19. Carney BI, Jones KL, Horowitz M, Sun WM, Penagini G, Meyer JH. Gastric emptying of oil and aqueous meal components in pancreatic insufficiency: Effects on posture and on appetite. Am J Physiol 1995;268:G925-G932.
20. Bergmann JF, Chassany O, Petit A, Triki R, Caulin C, Segrestaa JM. Correlation between echographic gastric emptying and appetite: Influences of psyllium. Gut 1992;33:1042-1043.
21. Rigaud D, Trostler N, Rozen R, Vallot T, Apfelbaum M. Gastric distention, hunger and energy intake after balloon implantation in severe obesity. Int J Obes Relat Metab Disord 1995;19:489-495.
22. Feinle C, Grundy D, Read NW. Effects of duodenal nutrients on sensory and motor responses of the human stomach to distension. Am J Physiol 1997;273:G721-G726.
23. Shafer RB, Levine AS, Marlette JM, Morley JE. Effects of xylitol on gastric emptying and food intake. Am J Clin Nutr 1987;45:744-747.
24. French SJ, Read NW. Effect of guar gum on hunger and satiety after meals of differing fat content: Relationship with gastric emptying. Am J Clin Nutr 1994;59:87-91.
25. Benini L, Brighenti F, Castellani G, Brentegani MT, Casiraghi MC, Ruzzenente O, Sembenini C, Pellegrini N, Caliari S, Porrini M. Gastric emptying of solids is markedly delayed when meals are fried. Dig Dis Sci 1994;39:2288-2294.
26. Jones KL, Doran SM, Hveem K, Bartholomeusz FDL, Morely JE, Sun WM, Chatterton BE, Horowitz M. Relation between postprandial satiation and antral area in normal subjects. Am J Clin Nutr 1997;66:127-132.
27. Koopmans HS. A stomach hormone that reduces food intake. J Auton Nerv Syst 1983;9:157-171.
28. Gutzwiller JP, Drewe J, Hildebrand P, Rossi L, Lauper JZ, Beglinger C. Effect of intravenous human gastric-releasing peptide on food intake in humans. Gastroenterology 1994; 106:1168-1173.
29. Lieverse RJ, Jansen JB, Masclee AM, Lamers CB. Effects of somatostatin on human satiety. Neuroendocrinology 1995; 61:112-116.
30. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJM. The stomach is a source of leptin. Nature 1998;394:790-793.
31. Breidert M, Miehlke S, Glasow A, Orban Z, Stolte M, Ehninger G, Bayerdoffer E, Nettesheim O, Halm U, Haidan A, Bornstein SR. Leptin and its receptor in normal human gastric mucosa and in Helicobacter pylori-associated gastritis. Scand J Gastroenterol 1999;34:954-961.
32. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: Novel peptides for new pathways. Cell 1998;92:437-440.
33. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998;393:72-76.
34. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexin and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92:573-585.
35. Leibowitz SF. Neurochemical-neuroendocrine systems in the rat brain controlling macronutrient intake and metabolism. Trends Neurosci 1992;15:491-497.
36. Schwartz GJ, McHugh PR, Moran TH. Integration of vagal afferent responses to gastric loads and cholecystokinin in rats. Am J Physiol 1991;261:R64-R69.
37. Willing AE, Berthoud HR. Gastric distention-induced c-fos expression in catecholaminergic neurons of rat dorsal vagal complex. Am J Physiol 1997;272:R59-R67.
38. Emond MH, Weingarten HP. Fos-like immunoreactivity in vagal and hypoglossal nuclei in different feeding states: A quantatitive study. Physiol Behav. 1995;58:459-465.
39. Asakawa A, Inui A, Veno N, Makino S, Fujino MA, Kasuga M. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology 1999;116: 1287-1292.
40. Wattwil M. Postoperative pain relief and gastointestinal motility. Acta Chir Scand Suppl 1989;550:140-145.
41. Clevers GJ, Smout AJ, van der Schee EJ, Akkermans LM. Myo-electrical and motor activity of the stomach in the first days after abdominal surgery: Evaluation by electrogastrography and impedance gastrography. J Gastroenterol Hepatol 1991;6:253-259.
42. Welch IM, Saunders K, Read NW. Effect of ileal and intravenous infusions of fat emulsions on feeding and satiety in human volunteers. Gastroenterology 1985;89:1293-1297.
43. Greenberg D, Lewis DR. Total but not selective hepatic vagotomy attenuates fat-induced satiety. In Proceedings of the Eleventh International Conference on the Physiology of Food and Fluid Intake. New York; Oxford University Press, 1993.
44. Chavez M, Kelly L, York DA, Berthoud HR. Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar high-fat diets in rats. Am J Physiol 1997;272: R1657-R1663.
45. Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC, Bloom SR, Misiewicz JJ, Silk DB. The ileal-brake inhibition of jejunal motility after ileal fat perfusion in man. Gut 1984;25:365-374.
46. Lin HC, Zhao XT, Wang L. Intestinal transit is more potently inhibited by fat in the distal (ileal brake) than in the proximal (jejunal brake) gut. Dig Dis Sci 1997;42:19-25.
47. Reidelberger ED, Kalogeris TJ, Leung PMB, Mandel VE. Postgastric satiety in the sham feeding rat. Am J Physiol 1983;244:R872-R881.
48. Greenberg D, Smith GP, Gibbs J. Intraduodenal infusion of fats elicit satiety in sham-feeding rat. Am J Physiol 1990; 259:R110-R118.
49. Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient. Am J Physiol 1989;256:G404-G411.
50. Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient. Am J Physiol 1990;259:G1031-1036.
51. Blackburn NA, Johnson IT. The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Br J Nutr 1981; 46:239-246.
52. Low AG, Rainbird AL, Gurr MI. Animal models for studying the effect of fiber on gastrointestinal fuction. J Plant Food 1982;4:29-32.
53. Mei N. Intestinal chemosensitivity. Physiol Rev 1985;65:211-237.
54. Berthoud HR, Kressel M, Raybould HE, Neuhuber WL. Vagal sensors in the rat duodenal mucosa: Distribution and structure as revealed by in vivo DiI-tracting. Anat Embryol 1995;191:203-212.
55. Schwartz GJ, Tougas G, Moran TH. Integration of vagal afferent responses to duodenal loads and exogenous CCK in fats. Peptides 1995;16:707-711.
56. Schwartz GJ, Moran TH. Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals. Neurosci Biobehav Rev 1996;20:47-56.
57. Sternini C, Wong H, Pham T, De Giorgio R, Miller LJ, Kuntz SM, Reeve JR, Walsh JH, Raybould HE. Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine. Gastroenterology 1999;117:1138-1146.
58. Buchan AM, Polak JM, Solcia E, Capella C, Hudson D, Pearse AG. Electron immunohistochemical evidence for human intestinal I cells as the source of CCK. Gut 1978;19: 403-407.
59. Schultzberg M, Hökfelt T, Nilsson G, Terenius L, Rehfeld JF, Brown M, Elde R, Goldstein M, Said S. Distribution of peptide- and catecholamine-containing neurons in the gastrointestinal tract of rat and guinea-pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase. Neuroscience 1980;5:689-744.
60. Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding and relationship to gallbladder contraction. J Clin Invest 1985;75:1144-1152.
61. Walsh JH, Lamers CB, Valenzuela JE. Cholecystokinin-octapeptidelike immunoreactivity in human plasma. Gastroenterology 1982;82:438-444.
62. Wank SA, Pisegna JR, de Weerth A. Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression. Proc Natl Acad Sci USA 1992;89:8691-8695.
63. Mantyh CR, Pappas TN, Vigina SR. Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology 1994; 107:1019-1030.
64. Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 1981;34:154-160.
65. West DB, Fey D, Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984;246:R776-R787.
66. Stacher G, Steinringer H, Schmierer C, Schneider C, Winklehner S. Cholecystokinin octapeptide decreases intake of solid food in man. Peptides 1982;3:133-136.
67. Ballinger A, McLoughlin L, Medback S, Clark M. Cholecystokinin is a satiety hormone in humans at physiological postprandial plasma concentrations. Clin Sci 1995;89:375-381.
68. Wolkowitz OM, Gertz B, Weingartner H, Beccaria L, Thompson K, Liddle RA. Hunger in humans induced by MK-329, a specific peripheral-type cholecystokinin receptor antagonist. Biol Psychiatry 1990;28:169-173.
69. Lieverse RJ, Jansen JB, van der Zwan A, Samson L, Masclee AA, Lamers CB. Effects of a physiological dose of cholecystokinin on food intake and postprandial satiation in man. Regul Pept 1993;43:83-89.
70. Lieverse RJ, Jansen JB, Masclee AA, Lamers CB. Satiety effects of a physiological dose of cholecystokinin in humans. Gut 1995;36:176-179.
71. French SJ, Murry B, Rumsey RD, Sepple CP, Read NW. Is cholecystokinin a satiety hormone? Correlations of plasma cholecystokinin with hunger, satiety and gastric emptying in normal volunteers. Appetite 1993;21:95-104.
72. Greenough A, Cole G, Lewis J, Lockton A, Blundell J. Untangling the effects of hunger, anxiety and nausea on energy intake during intravenous cholecystoldnin octapeptide (CCK-8) infusion. Physiol Behav 1998;65:303-310.
73. Schwartz GJ, McHugh PR, Moran TH. Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. Am J Physiol 1993;265:R872-R876.
74. Peikin SR. Role of cholecystokinin in the control of food intake. Gastroenterol Clin North Am 1989;18:757-775.
75. Plata-Salaman CR. Regulation of hunger and satiety in man. Dig Dis 1991;9:253-268.
76. Reidelberger RD, O'Rourke MF. Potent cholecystokinin antagonist L 364718 stimulates food intake in rats. Am J Physiol 1989;257:R1512-R1518.
77. Reuhi JC, Waser B, Laderach U, Stettler C, Friess H, Halter F, Schmassmann A. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology 1997;112:1197-1205.
78. Mercer JG, Lawrence CB. Selectivity of cholecystokinin (CCK) receptor antagonists, MK-329 and L-365260, for axonally-transported CCK binding sites on the rat vagus nerve. Neurosci Lett 1992;137:229-231.
79. Zittel TT, Elm BV, Teichman RK, Becker HD, Raybould HE. Cholecystokinin inhibits food intake at a peripheral extra gastric site. Ann N Y Acad Sci 1994;713:431-434.
80. Bell GI, Santerre RF, Mullenbach GT. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 1983;302:716-718.
81. Holst JJ. Enteroglucagon. Ann Rev Physiol 1997;59:257-271.
82. Ørskov C. Glucagon-like peptide-1, a new hormone of the enteroinsular axis. Diabetologia. 1992;35:701-711.
83. Hartmann B, Johnsen AH, Ørskov C, Adelhorst K, Thim L, Holst JJ. Structure, measurement, and secretion of human glucagon-like peptide-2. Peptides 2000;21:73-80.
84. Lankat-Buttgereit B, Göke R, Fehmann H-C, Richter G, Göke B. Molecular cloning of cDNA for the GLP-1 receptor expressed in rat lung. Exp Clin Endocrinol 1994;102: 341-347.
85. Schmidtler J, Dehne K, Allescher HD, Schusdziarra V, Classen M, Holst JJ, Polach A, Schepp W. Rat parietal cell receptors for GLP-1-(7-36)amide: Northen blot, cross-linking and radioligand binding. Am J Physiol 1994;267;G423-G432.
86. Valverde I, Merida E, Delgado E, Trapote MA, Villanueva-Penacarrillo ML. Presence and characterization of glucagon-like peptide-1 (7-36)amide receptors in solubilized membranes of rat adipose tissue. Endocrinology 1993;132:75-79.
87. Alvarez E, Roncero I, Chowen JA, Thorens B, Balzques E. Expression of the glucagon-like peptide-1 receptor gene in rat brain. J Neurochem 1996;66:920-927.
88. Kreymann B, Ghatei MA, Burnet P, Williams G, Kanse S, Diani AR, Bloom SR. Characterization of glucagon-like peptide-1-(7-36)amide in the hypothalamus. Brain Res 1989; 502:325-331.
89. Shimizu I, Hirota M, Ohboshi C, Shima K. Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 1987;121:1076-1082.
90. Kanse SM, Kreymann B, Ghatei MA, Bloom SR. Identification and characterization of glucagon-like peptide-1 7-36 amide - binding sites in the rat brain and lung. FEBS Lett 1988;241:209-212.
91. Göke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary. Neuroendocrinol 1995; 62:130-134.
92. Göke R, Larsen PJ, MikkelsenJD, Sheikh SP. Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995;7:2294-2300.
93. Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J 1993;7:683-686.
94. Wettergren A, Schjøldager B, Mortensen PE, Myhre J, ChristiansenJ, Holst JJ. Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 1993;38:665-673.
95. Näslund E, Bogefors J, Skogar S, Grybäck P, Jacobsson H, Holst JJ, Hellström PM. Glucagon-like peptide-1 slows solid gastric emptying with inhibition of insulin, C-peptide, glucagon and peptide YY release in humans. Am J Physiol 1999;277:R910-R916.
96. Wettergren A, Wøjdemann M, Meisner S, Stadil F, Holst JJ. The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36amide on gastric acid secretion in humans depends on an intact vagal innervation. Gut 1997;40:597-601.
97. Imeryüz N, Yegen BC, Bozkurt A, Coskun T, Villanueva-Penacarrillo ML, Ulusoy NB. Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. Am J Physiol 1997;273:G920-G927.
98. Wettergren A, Wøjdemann M, Holst JJ. Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am J Physiol 1998;275:G984-G992.
99. Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Ørskov C, Ritzel R, Schmeigel WH. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997;273:E981-E988.
100. McMahon LR, Wellman PJ. PVN infusion of GLP-1-(7-36)amide suppresses feeding but does not induce aversion or alter locomotion in rats. Am J Physiol 1998;274:1223-1229.
101. Tang-Christensen M, Larsen PJ, Göke R, Flink-Jensen A, Jessop DS, Møller M, Sheikh SP. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996;271:R848-R856.
102. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72.
103. Bloom SR. Glucagon-like peptide-1 and satiety. Nature 1997;385:214.
104. Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998;101:515-520.
105. Gutzwiller JP, Göke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, Winterhalder R, Conen D, Beglinger C. Glucagon-like peptide-1: A potent regulator of food intake in humans. Gut 1999;44:81-86.
106. Flint A, Raben A, Rehfeld JF, Holst JJ, Astrup A. The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans, Int J Obes Relat Metab Disord 2000;24:288-298.
107. Gutzwiller JP, Drewe J, Göke B, Schmidt H, Rohrer B, Lareida J, Beglinger C. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 1999;276:R1541-R1544.
108. Toft-Nielsen M-B, Madsbad S, Holst JJ. Continuous subcutaneous infusion of glucagon-like peptide-1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 1999;22:1137-1143.
109. Näslund E, Gutniak M, Skogar S, Rössner S, Hellström PM. Glucagon-like peptide-1 (GLP-1) increases the period of postprandial satiety and slows gastric emptying in obese humans. Am J Clin Nutr 1998;68:525-530.
110. Näslund E, Barkeling B, King N, Gutniak M, Blundell JE, Holst JJ, Rössner S, Hellström PM. Energy intake and appetite are suppressed by glucagon-like peptide-1 in obese men. Int J Obes Relat Metab Disord 1999;23:304-311.
111. Long SJ, Sutton JA, Amace WB, Giovanoudi A, Spyrou NM, Rogers PJ, Morgan LM. No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man. Br J Nutr 1999;8:273-279.
112. Ranganath LR, Beety JM, Morgan LM, Wright JW, Howland R, Marks V. Attenuated GLP-1 secretion in obesity: Cause or consequence. Gut 1996;38:916-919.
113. Näslund E, Grybäck P, Backman L, Jacobsson H, Holst JJ, Theodorsson E, Hellström PM. Small bowel gut hormones: Correlation to fasting antroduodenal motility and gastric emptying. Dig Dis Sci 1998;43:945-952.
114. Ranganath L, Norris F, Morgan L, Wright J, Marks V. Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36)amide secretion by circulating non-esterified fatty acids. Clin Sci 1999;96:335-342.
115. Clément K, Dina C, Basdevant A, Chastang N, Pelloux V, Lahlou N, Berlan M, Langin D, Guy-Grand B, Froguel P. A sib-pair analysis study of 15 candidate genes in French families with morbid obesity. Diabetes 1999;48;398-402.
116. Tsai CH, Hill M, Drucker DJ. Biological determinants of intestinotrophic properties of GLP-2. Am J Physiol 1997;272: G662-G668.
117. Lovshin J, Drucker DJ. New frontiers in the biology of GLP-2. Regul Pept 2000;90:27-32.
118. Wøjdemann M, Wettergren A, Hartmann B, Holst JJ. Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs. Scand J Gastroenterol 1998;33:828-832.
119. Wøjdemann M, Wettergren A, Hartmann B, Hilsted L, Holst JJ. Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2. J Clin Endocrinol Metab 1999;84:2513-2517.
120. Matson CA, Ritter RC. Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am J Physiol 1999;276:R1038-R1045.
121. Emond M, Schwartz GJ, Ladenheim EE, Moran TH. Central leptin modulates behavioral and neural responsivity to CCK. Am J Physiol 1999;276:R1545-R1549.
122. Broherger C, Holmherg K, Kuhar MJ, Hökfelt T. Cocaine-and amphetamine-regulated transcript in the rat vagus nerve. A putative mediator of cholecystokinin-induced satiety. Proc Natl Acad Sci USA 1999;96:13506-13511.
123. Goldstone AP, Mercer JG, Gunn I, Moar KM, Edwards CM, Rossi M, Howard JK, Rasheed S, Turton MD, Small C, Heath MM, O'Shea D, Steere J, Mecran K, Ghatei MA, Hoggard N, Bloom SR. Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett 1997;415:134-138.
124. Goldstone AP, Morgan I, Mercer JG, Morgan DG, Moar KM, Ghatei MA, Bloom SR. Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA. Biochem Biophys Res Commun 2000;269:331-335.
125. Nygren J, Soop M, Thorell A, Sree Nair K, Ljungqvist O. Preoperative oral carbohydrates and postoperative insulin resistance. Clin Nutr 1999;18:117-120.
126. Kehlet H, Morgensen T. Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme. Br J Surg 1999;86:227-230.
127. Karagiannakis AJ, Makri GG, Matziska A, Karousos D, Karatras G. Systemic stress response after laparoscopic or open cholecystectomy: A randomized trial. Br J Surg 1997; 84:467-471.
128. Lawaetz O, Blackburn AM, Bloom SR, Aritas Y, Ralphs DN. Gut hormone profile and gastric emptying in the dumping syndrome. A hypothesis concerning the pathogenesis. Scand J Gastroenterol 1983;18:73-80.
129. Kral JG. Effects of truncal vagotomy on body weight and hyperinsulinemia. Am J Clin Nutr 1980;33:416-419.
130. Görtz L, Björkman A-C, Andersson H, Kral JG. Truncal vagotomy reduces food and liquid intake in man. Physiol Behav 1990;48:779-781.
131. Jeppesen PB, Hartmann B, ThulesenJ, Hansen BS, Holst JJ, Poulsen SS, Mortensen PB. Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with preserved colon. Gut 2000;47:370-376.
132. Cannizzo F, Kral JG. Obesity surgery: A model of programmed undernutrition. Curr Opin Clin Nutr Metab Care 1998;1:363-368.
133. Wattchow DA, Furness JB, Costa M, O'Brien PE, Peacock M. Distributions of neuropeptides in the human esophagus. Gastroenterology 1987;93:1363-1371.
134. Aziz Q, Andersson JL, Valind S, Sundin A, Hamdy S, Jones AK, Foster ER, Langstrom B, Thompson DG. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 1997;113: 50-59.
135. Kral JG. Vagotomy as a treatment for severe obesity. Lancet 1978;I:307-308.
136. Kral JG, Kissileff HR. Surgical approaches to the treatment of obesity. Ann Behav Med 1987;9:15-19.
137. Kral JG, Görtz L, Hermanson G, Wallin GS. Gastroplasty for obesity: Long-term weight loss improved by vagotomy. World J Surg 1993;17:75-79.
138. Kellum JM, Kuemmerle JF, O'Dorisio TM, Rayford P, Martin D, Engle K, Wolf L, Sugerman HJ. Gastrointestinal homone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 1990;211:763-770.
139. Meryn S, Stein D, Straus EW. Fasting- and meal-stimulated peptide hormone concentrations before and after gastric surgery for morbid obesity. Metabolism 1986;35:798-802.
140. Meryn S, Stein D, Straus EW. Pancreatic polypeptide, pancreatic glucagon and enteroglucagon in morbid obesity and following gastric bypass operation. Int J Obes 1986;10: 37-42.
141. Sirinek KR, O'Dorisio TM, Hill D, Mc Fee AS. Hyperinsulinism, glucose-dependent insulinotropic polypeptide and the enteroinsulinar axis in morbidly obese patients before and after gastric bypass. Surgery 1986;100:781-787.
142. Kral JG. Malabsorptive procedures in surgical treatment of morbid obesity. Gastroenterol Clin North Am 1987;16: 293-305.
143. Näslund E, Grybäck P, Backman L, Jacobsson H, Holst JJ, Theodorsson E, Hellström PM. Small bowel gut hormones: Correlation to fasting antroduodenal motility and gastric emptying. Dig Dis Sci 1998;43:945-953.
144. Näslund E, Grybäck P, Hellström PM, Jacobsson H, Holst JJ, Theodorsson E, Backman L. Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity. Int J Obes Relat Metab Disord 1997;48:387-392.
145. Scopinaro N, Gianetta E, Adami GF, Friedman D, Traverse E, Marinari GM, Cuneo S, Vitale B, Ballari F, Colombri M, Baschieri G, Bachi V. Biliopancreatic diversion for obesity at eighteen years. Surgery 1996;119:261-268.
146. Marceau P, Hould FS, Simard S, Lebel S, Bourgue RA, Potvin M, Biron S. Biliopancreatic diversion with duodenal switch. World J Surg 1998;22:947-954.
147. Sarson DL, Scopinaro N, Bloom SR. Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity. Int J Obes 1981;5:471-480.
148. Wilson P, Welch NT, Hinder RA, Anselmino M, Herrington MK, DeMeester TR, Adrian TE. Abnormal plasma gut hormones in pathologic duodenogastric reflux and their response to surgery. Am J Surg 1993;165:169-176.