Presence of a Population of CD20+,CD38- B Lymphocytes with Defective Proliferative Responsiveness in the Synovial Compartment of Patients with Rheumatoid Arthritis

Arthritis and Rheumatism

Volumn 44, Issue 9, 2001, Pages 2029-2037

  Reparon Schuijt, Carelle C ^a   Van Esch, Wim J E ^a   Van Kooten, Cees ^a   Ezendam, Nicole P M ^a   Levarht, Eleonora W N ^a   Breedveld, Ferdinand C ^a   Verweij, Cornelis L ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CARCINOGEN; CD20 ANTIGEN; CD38 ANTIGEN; CD38 PROTEIN, HUMAN; CD40 ANTIGEN; CD40 LIGAND; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 2; IONOMYCIN; IONOPHORE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE NUCLEOSIDASE; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CALCIUM SIGNALING; CELL CULTURE; CELL DIVISION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FEMALE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; PATHOLOGY; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; T LYMPHOCYTE;

ADP-RIBOSYL CYCLASE; ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD38; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CALCIUM SIGNALING; CARCINOGENS; CD40 LIGAND; CELL DIVISION; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOGLOBULINS; INTERLEUKIN-10; INTERLEUKIN-2; IONOMYCIN; IONOPHORES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NAD+ NUCLEOSIDASE; OXIDATION-REDUCTION; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 0035463152     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200109)44:9<2029::AID-ART352>3.0.CO;2-2     Document Type: Article

References (54)

1. Sprent J. T and B memory cells. Cell 1994;76:315-22.
2. Mackay CR. Immunological memory. Adv Immunol 1993;53: 217-65.
3. MacLennan ICM. Germinal centers. Annu Rev Immunol 1994;12: 117-39.
4. Jacob J, Przylepa J, Miller C, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med 1993;178:1293-307.
5. McHeyzer-Williams MG, McLean MJ, Lalor PA, Nossal GJ. Antigen-driven B cell differentiation in vivo. J Exp Med 1993;178: 295-307.
6. Liu YJ, Malisan F, de Bouteiller O, Guret C, Lehecque S, Banchcreau J, et al. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 1996;4:241-50.
7. Martinez-Valdez H, Malisan F, de Bouteiller O, Guret C, Banchereau J, Liu YJ. Molecular evidence that in vivo isotype switching occurs within the germinal centers. Ann N Y Acad Sci 1995;764: 151-4.
8. Arpin C, Dechanet J, van Kooten C, Merville P, Grouard G, Brière F, et al. Generation of memory B cells and plasma cells in vitro. Science 1995;268:720-2.
9. Choc J, Sung Choi Y. IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells. Eur J Immunol 1998;27:508-15.
10. Vora KA, Tumas-Brundage K, Manser T. Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses. J Immunol 1999;163:4315-27.
11. Liu Y-J, Barthélémy C, de Bouteiller O, Arpin C, Durand I, Banchereau J. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 1995;2:239-48.
12. Liu YJ, Zhang J, Lane PJ, Chan EY, MacLennan IC. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur J Immunol 1991;21:2951-62.
13. Randen I, Mellbye OJ, Førre Ø, Natvig JB. The identification of germinal centers and follicular dendritic cell networks in rheumatoid synovial tissue. Scand J Immunol 1995;41:481-6.
14. Berek C, Schröder AE. A germinal center-like reaction in the nonlymphoid tissue of the synovial membrane. Ann N Y Acad Sci 1997;815:211-7.
15. Berek C, Kim H-J. B cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis. Semin Immunol 1997;9:261-8.
16. Gause A, Gundlach K, Jacobs G, Koch B, Hopf T, Pfreundschuh M. The B lymphocyte in rheumatoid arthritis: analysis of rearranged VK genes from B cells infiltrating the synovial membrane. Eur J Immunol 1995;25:2775-82.
17. Schröder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 1996;93:221-5.
18. Reparon-Schuijt CC, van Esch WJE, van Kooten C, Levarht EWN, Breedveld FC, Verweij CL. Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients. Arthritis Rheum 1998;41:2211-20.
19. Youinou PY, Morrow JW, Lettin AW, Lydyard PM, Roitt IM. Specificity of plasma cells in the rheumatoid synovium. I. Immunoglobulin class of antiglohulin-producing cells. Scand J Immunol 1984;20:307-15.
20. Kim H-J, Krenn V, Steinhauser G, Berek C. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis. J Immunol 1999;162:3053-62.
21. Otten HG, Daha MR, Dolhain RJEM, de Rooy HH, Breedveld FC. Rheumatoid factor production by mononuclear cells derived from different sites of patients with rheumatoid arthritis. Clin Exp Immunol 1993;94:236-40.
22. Munthe E, Natvig JB. Immunoglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells. Clin Exp Immunol 1972;12:55-70.
23. Jakle C, Feigal DW, Robbins DL, Shapiro R, Wiesner K. Serum IgG and IgM rheumatoid factors and complement activation in extra-articular rheumatoid disease. J Rheumatol 1985;12:227-32.
24. Mannik M. Rheumatoid factors in the pathogenesis of rheumatoid arthritis. J Rheumatol 1992;19:46-9.
25. Munthe E, Natvig JB. Complement-fixing intracellular complexes of IgG rheumatoid factor in rheumatoid plasma cells. Scand J Immunol 1972;1:217-29.
26. Natvig JB, Førre Ø, Randen I, Steinitz M, Thompson K, Waalen K. B lymphocytes, B cell clones and rheumatoid factor antibodies in rheumatoid inflammation. Scand J Rheumatol Suppl 1988;76: 217-27.
27. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
28. Maurice MM, Res PCM, Leow A, van Hall T, Daha MR, Struijk P, et al. Joint-derived T cells in rheumatoid arthritis proliferate to antigens present in autologous synovial fluid. Scand J Rheumatol 1995;24:169-77.
29. Galibert L, Burdin N, de Saint-Vis B, Garrone P, van Kooten C, Banchereau J, et al. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med 1996;183:77-85.
30. Garrone P, Neidhardt E-M, Garcia E, Galibert L, van Kooten C, Banchereau J. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J Exp Med 1995;182:1265-73.
31. Van Kooten C, Galibert L, Seon BK, Garrone P, Liu Y-J, Banchereau J. Cross-linking of antigen receptor via Ig-β (B29,CD79b) can induce both positive and negative signals in CD40-activated human B cells. Clin Exp Immunol 1997;110: 509-15.
32. Galibert L, Burdin N, Barthélémy C, Meffre G, Durand I, Garcia E, et al. Negative selection of human germinal center B cells by prolonged BCR cross-linking. J Exp Med 1996;183:2075-85.
33. Arpin C, Banchereau J, Liu Y-J. Memory B cells are biased towards terminal differentiation: a strategy that may prevent repertoire freezing. J Exp Med 1997;186:931-40.
34. Maurice MM, Nakamura H, van der Voort EAM, van Vliet AI, Staal FJT, Tak PP, et al. Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J Immunol 1997;158:1458-65.
35. MacLennan IC, Gray D. Antigen-driven selection of virgin and memory B cells. Immunol Rev 1986;91:61-85.
36. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996;272:54-6(1.
37. Klein U, Rajewski K, Kuppers R. Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-89.
38. Tangye S, Liu Y-J, Aversa G, Phillips JH, de Vries JE. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998;188:1691-703.
39. Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997;159: 2973-8.
40. Gringhuis SI, Leow A, Papendrecht-van der Voort EAM, Remans PH, Breedveld FC, Verweij CL. Displacement of LAT from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis. J Immunol 2000;164:2170-9.
41. Qin S, Minami Y, Hibi M, Kurosaki T, Yamamura H. Sykdependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress. J Biol Chem 1998;272:2098-103.
42. Lee JR, Koretzky GA. Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine lymphocytes. Eur J Immunol 1998;28:4188-97.
43. Suzuki Y, Ohsugi K, Ono Y. Oxidative stress triggers tyrosine phosphorylation in B cells through a redox- and inflammatory cytokine-sensitive mechanism. Immunology 1998;87:396-401.
44. Jeannin P, Delnest Y, Lecoanet-Henchoz S, Gauchat J-F, Life P, Holmes D, et al. Thiols decrease human interleukin (IL-4) production and IL-4-induced immunoglobulin synthesis. J Exp Med 1995;182:1785-92.
45. Craxton A, Shu G, Graves JD, Saklatvala J, Krebs EG, Clark EA. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol 1998;161:3225-36.
46. Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, Fu C, et al. BLNK required for coupling Syk to PLCg2 and Rac-1-JNK in B cells. Immunity 1999;10:117-25.
47. Tumang JR, Owyang A, Andjelic S, Jin Z, Hardy RR, Liou M-L, et al. c-Rel is essential for B lymphocyte survival and cell cycle progression. Eur J Immunol 1998;28:4299-312.
48. Kontgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995;9:1965-77.
49. Sha WC, Liou H-C, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 1995;80:321-30.
50. Snapper CM, Rosas FR, Zelazowski P, Moorman MA, Kehry MR, Bravo R, et al. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J Exp Med 1996;184:1537-41.
51. H transcription, and Ig class switching. J Immunol 1996;156:183-91.
52. Von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts. Exp Cell Res 1995;220:186-93.
53. Oikawa Y, Kawanishi S. Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 1999;453:365-8.
54. Hodes RJ. Telomere length, aging, and somatic cell turnover. J Exp Med 1999;190:153-6.