Evidence for the Role of an Altered Redox State in Hyporesponsiveness of Synovial T Cells in Rheumatoid Arthritis

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1458-1465

  Maurice, Madelon M ^a   Nakamura, Hajime ^c,d   Van Der Voort, Ellen A M ^a   Van Vliet, Anita I ^a   Staal, Frank J T ^b   Tak, Paul Peter ^a   Breedveld, Ferdinand C ^a   Verweij, Cornelis L ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; THIOREDOXIN;

ADULT; AGED; ARTICLE; FEMALE; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; OXIDATION REDUCTION REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; ARTHRITIS, RHEUMATOID; FEMALE; GLUTATHIONE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; OSTEOARTHRITIS; OXIDATION-REDUCTION; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THIOREDOXIN;

EID: 0031065210     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Harris, E. D. 1990. Reumatoid arthritis: pathophysiology and implications for therapy. N. Engl. J. Med. 322:1277.
2. Panayi, G. S., J. S. Lanchbury, and G. H. Kingsley. 1992. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35:729.
3. Howell, M., and J. Smith. 1992. The rheumatoid synovium: a model for T cell anergy? Immunol. Today 13:191.
4. Firestein, G. S., and N. J. Zvaifler. 1990. How important are T cells in chronic rheumatoid arthritis? Arthritis Rheum. 33:768.
5. Hemler, M. E., D. Glass, J. S. Coblyn, and J. G. Jacobson. 1986. Very late activation antigens on rheumatoid synovial T lymphocytes. Association with stages of T cell activation. J. Clin. Invest. 78:696.
6. Takahashi, H., K. Söderström, E. Nilsson, R. Kiessling, and M. Patarroyo. 1992. Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur. J. Immunol. 22:2879.
7. Duke, O., G. S. Panayi, G. Janossy, L. W. Poulter, and N. H. Tidman. 1983. Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies. Ann. Rheum. Dis. 42:357.
8. Afeltra, A., M. Galeazzi, G. M. Ferri, A. Amoroso, O. De Pita, F. Porzio, and L. Bonomo. 1993. Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and chronic synovitis. Ann. Rheum. Dis. 52:457.
9. Galeazzi, M., A. Afeltra, F. Porzio, and L. Bonomo. 1990. The activation markers on synovial T-cells of rheumatoid arthritis. Clin. Rheumatol. 9:561.
10. Laffon, A., R. Garcia Vicuna, A. Humbria, A. A. Postigo, A. L. Corbi, M. O. de Landazuri, and F. Sanchez Madrid. 1991. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J. Clin. Invest. 88:546.
11. 3H]thymidine incorporating cells in rheumatoid arthritis synovial membrane. Rheumatol. Int. 6:269.
12. Haraoui, B., R. L. Wilder, D. G. Malone, J. B. Allen, I. M. Katona, and S. M. Wahl. 1984. Immune function in severe, active rheumatoid arthritis: a relationship between peripheral blood mononuclear cell proliferation to soluble antigens and mononuclear cell subset profiles. J. Immunol. 133:697.
13. Kingsley, G. H., C. Pitzalis, and G. S. Panayi. 1987. Abnormal lymphocyte reactivity to self-major histocompatibility antigens in rheumatoid arthritis. J. Rheumatol. 14:677.
14. Verwilghen, J., S. Vertessen, E. A. M. Stevens, J. Dequeker, and J. L. Ceuppens. 1990. Depressed T cell reactivity to recall antigens in rheumatoid arthritis. J. Clin. Immunol. 10:90.
15. Keystone, E. C., L. Poplonski, R. G. Miller, R. Gorczynski, D. Gladman, and K. Snow. 1988. Reactivity of T cells from patients with rheumatoid arthritis to anti-CD3 antibody. Clin. Immunol. Immunopathol. 48:325.
16. Pope, R. M., L. McChesney, N. Talal, and M. Fischbach. 1984. Characterization of the defective autologous mixed lymphocyte response in rheumatoid arthritis patients. Arthritis Rheum. 27:1234.
17. Mirza, N. M., V. Relias, E. J. Yunis, W. N. Pachas, and J. D. Dasgupta. 1993. Defective signal transduction via T-cell receptor-CD3 structure in T cells from rheumatoid arthritis patients. Hum. Immunol. 36:91.
18. Allen, M. E., S. P. Young, R. H. Michell, and P. A. Bacon. 1995. Altered T lymphocyte signaling in rheumatoid arthritis. Eur. J. Immunol. 25:1547.
19. Firestein, G. S., W. D. Xu, K. Townsend, D. Broide, J. Alvaro-Gracia, A. Glasebrook, and N. J. Zvaifler. 1988. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J. Exp. Med. 168:1573.
20. Firestein, G. S., and N. J. Zvaifler. 1987. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 30:864.
21. Cope, A. P., M. Londei, N. R. Chu, S. B. A. Cohen, M. J. Elliot, F. M. Brennan, R. N. Maini, and M. Feldmann. 1994. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; Reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J. Clin. Invest. 94:749.
22. Lai, N.-S., J.-L. Lan, C.-L. Yu, and R.-H. Lin. 1995. Role of tumor necrosis factor-α in the regulation of activated synovial T cell growth: downregulation of synovial T cells in rheumatoid arthritis patients. Eur. J. Immunol. 25:3243.
23. Flescher, E., J. A. Ledbetter, G. L. Schieven, N. Vela-Roch, D. Possum, H. Dang, N. Ogawa, and N. Talal. 1994. Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction. J. Immunol. 153:4880.
24. Suthanthiran, M., M. E. Anderson, V. K. Sharma, and A. Meister. 1990. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc. Natl. Acad. Sci. USA 87:3343.
25. Roederer, M., F. J. T. Staal, H. Osada, and L. A. Herzenberg. 1991. CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Int. Immunol. 3:933.
26. Staal, F. J. T., S. W. Ela, M. Roederer, M. T. Anderson, and L. A. Herzenberg. 1992. Glutathione deficiency and human immunodeficiency virus infection. Lancet 339:909.
27. Staal, F. J. T., M. T. Anderson, G. E. J. Staal, L. A. Herzenberg, and C. Gitler. 1994. Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Proc. Natl. Acad. Sci. 91:3619.
28. Chilles, C., M. Mulheron, F. M. McCrae, W. E. Reglinski, and R. D. Sturrock. 1990. Concentration and reactivity of the sulphydryl group population on the membrane of intact erythrocytes in patients with rheumatoid arthritis. Ann. Rheum. Dis. 49:668.
29. Munthe, E., E. Kass, and E. Jelum. 1981. D-Penicillamine induced increase in intracellular glutathione correlating to response in rheumatoid arthritis. J. Rheumatol. 8(Suppl.7):14.
30. Holmgren, A. 1985. Thioredoxin. Annu. Rev. Biochem. 54:237.
31. Holmgren, A. 1989. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 260: 93.
32. Yodoi, J., and T. Tursz. 1991. ADF, a growth-promoting factor derived from adult T cell leukemia and homologous to thioredoxin: involvement in lymphocyte immortalization by HTLV-1 and EBV. Adv. Cancer Res. 57:381.
33. Nakamura, H., S. DeRosa, M. Roederer, M. T. Anderson, J. G. Dubs, J. Yodoi, A. Holmgren, and L. A. Herzenberg. 1996. Elevation of plasma thioredoxin levels in HIV-infected individuals. Int. Immunol. 8:603.
34. Björnstedt, M., J. Xue, W. Huang, B. Akesson, and A. Holmgren. 1994. The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. J. Biol. Chem. 269:29382.
35. Arnett, F. C., S. M. Edworthy, D. A. Bloch, D. J. McShane, J. F. Fries, N. S. Cooper, L. A. Healey, S. R. Kaplan, M. H. Liang, H. S. Luthra, T. A. Medsger, D. M. Mitchell, D. H. Neustadt, R. S. Pinals, J. G. Schaller, J. T. Sharp, R. L. Wilder, and G. G. Hunder. 1987. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315.
36. Tietze, F. 1969. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27:502.
37. Griffith, O. W. 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106:207.
38. Staal, F. J. T., M. Roederer, D. M. Israelski, J. Bubp, L. A. Mole, and D. McShane. 1992. Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals. AIDS Res. Hum. Retroviruses 8:305.
39. Kavanagh, T. J., A. Grossmann, J. C. Jinneman, S. B. Kanner, C. C. White, D. L. Eaton, J. A. Ledbetter, and P. S. Rabinovitch. 1993. The effect of 1-chloro-2,4-dinitrobenzene exposure on antigen receptor (CD3)-stimulated transmembrane signal transduction in purified subsets of human peripheral blood lymphocytes. Toxicol. Appl. Pharmacol. 119:91.
40. Smyth, M. J. 1991. Glutathione modulates activation-dependent proliferation of human peripheral blood lymphocyte populations without regulating their activated function. J. Immunol. 146:1921.
41. Liang, S.-M., N. Lee, Y. Chen, and C.-M. Liang. 1992. Effects of glutathione on the synthesis and turnover of interleukin-2 receptors. Cell. Immunol. 144:131.
42. Verwilghen, J., V. Corrigall, R. M. Pope, R. Rodrigues, and G. S. Panayi. 1993. Expression and function of CD5 and CD28 in patients with rheumatoid arthritis. Immunology 80:96.
43. Lotz, M., C. D. Tsoukas, C. A. Robinson, C. A. Dinarello, D. A. Carson, and J. H. Vaughan. 1986. Basis for defective response of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3(T3) antibodies. J. Clin. Invest. 78:713.
44. Schenk, H., M. Vogt, W. Dröge, and K. Schulze-osthoff. 1996. Thioredoxin as a potent costimulus of cytokine expression. J. Immunol. 156:765.
45. Heliövaara, M., P. Knekt, K. Aho, G. Alfthan, and A. Aromaa. 1994. Serum antioxidants and risk of rheumatoid arthritis. Ann. Rheum. Dis. 53:51.
46. Salonen, J., K. Nyyssönen, T. -P. Tuomainen, P. H. Mäenpää, H. Korpela, G. A. Kaplan, J. Lynch, S. P. Helmrich, and R. Salonen. 1995. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four-year follow-up study in men. Br. Med. J. 311:1124.
47. Huck, F., R. Médicis, A. Lussier, G. Dupuis, and P. Federlin. 1984. Reducing properties of some slow acting antirheumatic drugs. J. Rheumatol. 11:605.
48. Halliwell, B., J. R. Hoult, and D. R. Blake. 1988. Oxidants, inflammation, and anti-inflammatory drugs. FASEB J. 2:2867.
49. Poot, M., H. Teubert, P. S. Rabinovitch, and T. J. Kavanagh. 1995. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. J. Cell. Phys. 163:555.
50. 2. J. Clin. Invest. 89:794.
51. Klebanoff, S. J., M. A. Vadas, J. M. Harlan, L. H. Sparks, J. R. Gamble, J. M. Agosti, and A. M. Waltersdorph. 1986. Stimulation of neutrophils by tumor necrosis factor. J. Immunol. 136:4220.
52. Kanner, S. B., T. J. Kavanagh, A. Grossmann, S.-L. Hu, J. B. Bolen, P. S. Rabinovitch, and J. A. Ledbetter. 1992. Sulphydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase Cγ1. Proc. Natl. Acad. Sci. USA 89:300.
53. El-Hag, A., and R. A. Clark. 1987. Immunosuppression by activated human neutrophils. J. Immunol. 139:2406.
54. El-Hag, A., P. E. Lipsky, M. Bennett, and R. A. Clark. 1986. Immunomodulation by neutrophil myeloperoxidase and hydrogen peroxide: differential susceptibility of human lymphocyte functions. J. Immunol. 136:3420.