Bacterial superantigens: Provocateurs of gut dysfunction and inflammation?

Trends in Immunology

Volumn 22, Issue 9, 2001, Pages 497-501

  McKay, Derek M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; SUPERANTIGEN;

BACTERIUM; CELLULAR IMMUNITY; CROHN DISEASE; DISEASE EXACERBATION; HUMAN; HYPOTHESIS; IDIOPATHIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; QUALITY OF LIFE; REVIEW; SPECIES DIFFERENCE; T LYMPHOCYTE; ULCERATIVE COLITIS;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL INFECTIONS; HUMANS; INFLAMMATORY BOWEL DISEASES; SUPERANTIGENS;

EID: 0035451750     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02000-2     Document Type: Review

References (54)

1. Superantigens - Powerful modifiers of the immune system
2. Understanding the mechanism of action of bacterial superantigens from a decade of research
3. The structural basis of T-cell activation by superantigens
4. Intestinal inflammation and the gut microflora
5. Staphylococcal enterotoxin gastroenteritis in rhesus monkeys
6. Role of staphylococcal enterotoxin in the induction of experimental ileitis
7. + T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B
8. Colonic epithelial physiology is altered in response to the bacterial superantigen Yersinia pseudotuberculosis mitogen (YPM)
9. + T cells
10. + T cells mediate superantigen-induced abnormalities in murine jejunal ion transport
11. Nitric oxide participates in the recovery of normal jejunal epithelial ion transport following exposure to the superantigen Staphylococcus aureus enterotoxin B
12. The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin-B-induced shock in mice
13. 2
14. Superantigen immune stimulation evokes epithelial monocyte chemoattractant protein 1 and RANTES production
15. Epithelial transport and barrier abnormalities evoked by superantigen-activated immune cells are inhibited by IL-10, but not IL-4
16. The intestinal barrier: A hypothesis as to its regulation and involvement in Crohn's disease
17. Distribution and kinetics of superantigen-induced cytokine expression in mouse spleen
18. A role for TNF-α and mucosal T helper 1 cytokines in the pathogenesis of Crohn's disease
19. Evidence for involvement of bacterial superantigens in psoriasis, atoptic dermatitis and Kawasaki syndrome
20. Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis
21. Evidence for the effects of a superantigen in rheumatoid arthritis
22. Evidence for superantigen involvement in insulin-dependent diabetes mellitus etiology
23. Is celiac disease due to molecular mimicry between gliadin peptide-HLA class II molecule-T cell interactions and those of some unidentified superantigen?
24. + T cells in Crohn's disease
25. Selective expansion of specific T-cell receptors in the inflamed colon of Crohn's disease
26. Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability
27. Specific clonal T-cell accumulation in intestinal lesions of Crohn's disease
28. Mycoplasma superantigen is a CDR3-dependent ligand for the T-cell antigen receptor
29. Evidence for a superantigen in human tuberculosis
30. On the etiology of Crohn's disease
31. Identification of a novel bacterial sequence associated with Crohn's disease
32. The Crohn's disease-associated bacterial protein I2 is a novel enteric T-cell superantigen
33. Lipopolysaccharide interferes with the induction of peripheral T-cell death
34. CD28 engagement and proinflammatory cytokines contribute to T-cell expansion and long-term survival in vivo
35. Danger and OX40 receptor signaling synergise to enhance memory T-cell survival by inhibiting peripheral deletion
36. 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
37. Superantigen and endotoxin synergise in the induction of lethal shock
38. CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis
39. Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin, superantigen or TNF results in TNFR1- and TNFR2-dependent liver toxicity in mice
40. The presence of peptidoglycan-polysaccharide complexes in the bowel wall and the cellular responses to these complexes in Crohn's disease
41. Independent contribution of HLA-DRB1 and TNF-α promoter polymorphisms to the susceptibility to Crohn's disease
42. HLA-DR and -DQ phenotypes in inflammatory bowel disease: A meta-analysis
43. Staphylococcal enterotoxin B stimulates expansion of autoreactive T cells that induce apoptosis in intestinal epithelial cells: Regulation of autoreactive responses by IL-10
44. The possible role of bacterial superantigens in the pathogenesis of autoimmune disorders
45. Superantigens can reactivate bacterial cell wall-induced arthritis
46. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
47. T-cell subsets in experimental lupus nephritis: Modulation by bacterial superantigen
48. Intra-colonic delivery of bacterial superantigens reactivates inflammation in mice recovering from dextran sulphate sodium (DSS)-induced colitis
49. Inflammatory bowel disease: Etiology and pathogenesis
50. Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC II receptors
51. + cells
52. T-cell activation in human intestinal mucosa: The role of superantigens
53. + lymphocytes
54. Adult worm homogenate of the nematode parasite Heligmosomoides polygyrus induces proliferation of naive T lymphocytes without MHC restriction