Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease

Journal of Clinical Investigation

Volumn 98, Issue 6, 1996, Pages 1344-1354

  Gulwani Akolkar, Beena ^a   Akolkar, Pradip N ^a   Minassian, Arax ^a   Pergolizzi, Robert ^a   McKinley, Mathew ^a   Mullin, Gerald ^a   Fisher, Stanley ^a   Silver, Jack ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

CD4+ lymphocytes; Crohn's disease; inflammatory bowel disease; lamina propria lymphocytes; T cell receptor

Indexed keywords

BIOCHEMICAL MARKER; T LYMPHOCYTE RECEPTOR;

ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; CLONAL ANERGY; COLITIS; CROHN DISEASE; DNA SEQUENCE; ENTERITIS; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LAMINA PROPRIA; PATHOGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0029773838     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118921     Document Type: Article

References (45)

1. MacDermott, R.P., and W.F. Stenson. 1988. Alterations of the immune system in ulcerative colitis and Crohn's disease. Adv. Immunol. 42:285-326.
2. Kirsner, J.B., and R.G. Shorter. 1982. Recent developments in nonspecific inflammatory bowel disease. N. Engl. J. Med. 306:837-848.
3. Fiocchi, C. 1986. Intestinal mucosal lmphocytes: a new approach to pathogenesis of inflammatory bowel disease. In Inflammatory Bowel Diseases. D. Rachmilewitz, editor. Martinus Nijhoff Publishers, Dordrecht, The Netherlands. p. 73-85.
4. Strober, W., and S.P. James. 1986. The immunologic basis of inflammatory bowel disease. J. Clin. Immunol. 6:415-432.
5. James, S.P., W. Strober, T.C. Quinn, and S.H. Danovitch. 1987. New concepts of pathogenesis and current approaches to treatment. Dig. Dis. Sci. 32: 1297-1310.
6. Walvoort, H.C., and A.S. Pena. 1987. Crohns disease: entity and aetiopathogenic concepts. J. Clin. Nutr. Gastroenterol. 32:194-200.
7. Mayer, L., and D. Eisenhardt. 1990. Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. J. Clin. Invest. 86:1255-1260.
8. + T cells in Crohn's disease. J. Clin. Invest. 85:1770-1776.
9. Strober, W., and R.O. Ehrhardt. 1993. Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell. 75: 203-205.
10. Powrie, F. 1995. T cells in inflammatory disease: protective and pathogenic roles. Immunity. 3:171-174.
11. Lowes, J.R., and D.P. Jewell. 1990. The immunology of inflammatory bowel disease. Spingers Sem. Immunopathol. 12:251-268.
12. Deusch, K., and K. Reich. 1992. Immunological aspects of inflammatory bowel disease. Endoscopy. 24:568-577.
13. Fiochi, C. 1990. Immune events associated with inflammatory bowel disease. Scand. J. Gastroenterol. 25:4-12.
14. James, S.P., C. Fiochi, A.S. Graeff, and W. Strober. 1985. Immunoregulatory function of lamina propria T cells in Crohn's disease. Gastroenterology. 85:1143-1150.
15. Raedler, A., S. Fraenkel, G. Klose, K. Seyfarth, and H.G. Thiele. 1985. Involvement of the immune system in the pathogenesis of Crohn's disease. Expression of the T9 antigen on peripheral immunocytes correlates with the severity of the disease. Gastroenterology. 88:978-983.
16. Raedler, A., S. Fraenkel, G. Klose, and H.G. Thiele. 1985. Elevated numbers of peripheral T cells in inflammatory bowel disease displaying the T9 antigen and Fc receptors. Clin. Exp. Immunol. 60:518-524.
17. Schreiber, S., R.P. MacDermott, A. Raedler, R. Pinnau, M.J. Bertovich, and G.S. Nash. 1991. Increased activation of isolated intestinal lamina propia mononuclear cells in inflammatory bowel disease. Gastroenterology. 101:1020-1030.
18. Pallone, F., S. Fais, O. Squarcia, L. Biancone, P. Pozzill, and M. Boirivant. 1987. Activation of peripheral blood and lamina propia lymphocytes in Crohn's disease. In vivo stale of activation and in vitro response to stimulation as defined by the expression of early activation antigens. Gut. 28:745-753.
19. Konttinen, Y.T., V. Bergroth, D. Nordstrom, M. Segerberg-Konttinen, K. Seppala, and M. Salaspur. 1987. Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn's disease. J. Clin. Lab. Immunol. 22:59-63.
20. Mullin, G.E, A. Lazenby, M. Harris, T. Bayless, and S.P. James. 1992. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology. 102:1620-1627.
21. Breese, E., C.P. Braegger, C.J. Corrigan, J.A. Walker-Smith, and T.T. MacDonald. 1993. Interleukin 2 and interferon-gamma secreting T cells in normal and diseased intestinal mucosa. Immunology. 78:127-131.
22. Mullin, G.E., Z.R. Maycon, A. Sampat, F.R. Vezza, L.B. Elwert-Braun, R. Duchmann, G. Weissman, S. Katz, M.M. McKinley, S.P. James, and S.E. Fisher. 1994. Intestinal mucosal lymphokine production in Crohn's disease has a Th1 profile. Gastroenterology. 104:A705.
23. Choy, M.Y., J.A. Walker-Smith, C.B. Williams, and T.T. MacDonald. 1990. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut. 31:1365-1370.
24. +, lamina propia lymphocytes. Clin. Immunol. Immunopathol. 77:95-105.
25. Yardley, J.H., and M. Donowitz. 1977. Colo-rectal biopsy in inflammatory bowel disease. In The Gastrointestinal Tract. J.H. Morrison, B.C. Morson, and M.R. Abell, editors. Williams and Wilkins, Baltimore, MD. p. 50-94.
26. Bull, D.M., and M.A. Bookman. 1977. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J. Cell. Invest. 59:966-974.
27. Gulwani-Akolkar, B., D.N. Posnett, C.H. Janson, J. Grunewald, H. Wigzell, P. Akolkar, P. Gregersen, and J. Silver. 1991. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J. Exp. Med. 174:1139-1146.
28. Akolkar, P.N., B. Gulwani-Akolkar, R. Pergolizzi, R.D. Bigler, and J. Silver. 1993. The influence of HLA genes on TCR V-segment frequencies and expression levels in peripheral blood lymphocytes. J. Immunol. 150:4761-4773.
29. Akolkar, P.N., B. Gulwani-Akolkar, and J. Silver. 1996. Methods for the analysis of the human T cell receptor (TCR) repertoire in health and disease. In CRC Handbook of Human Immunology. CRC Press, Boca Raton, FL. In press.
30. Akolkar, P.N., B. Gulwani-Akolkar, M. McKinley, S.E. Fisher, and J. Silver. 1995. Comparisons of T cell receptor (TCR) Vβ repertoire of lamina propia and peripheral blood lymphocytes. Clin. Immunol. Immunopathol. 76:155-163.
31. + T cells in normal human subjects. J. Immunol. 151:5762-5769.
32. Blumberg, R.S., C.E. Yockey, G.G. Gross, E.C. Ebert, and S.P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ receptor genes. J. Immunol. 150:5144-5153.
33. Herman, A., J.W. Kappler, P. Marrack, and A.M. Pullen. 1991. Superantigens: mechanism of T cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:7745-7772.
34. Drake, C.G., and B.L. Kotzin 1992. Superantigens: biology, immunology, and potential role in disease. J. Clin. Immunol. 12:149-162.
35. Weyand, C.M., X. Congping, and J.J. Goronzy. 1992. Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. J. Clin. Invest. 89:2033-2039.
36. Weyand, C.M., K.C. Hicok, D.L. Conn, and J.J. Goronzy. 1992. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann. Int. Med. 117:801-806.
37. Nepom, G.T. 1995. Class II antigens and disease susceptibility. Annu. Rev. Med. 46:17-25.
38. Hammer, R.E., S.D. Maika, J.A. Richardson, J.P. Tang, and J.D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and humanβ-2m: and animal model of HLA-B27-asssocialed human disorders. Cell. 63:1099-1112.
39. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Miller. 1993. Interleukin-10 deficient mice develop chronic colitis. Cell. 75:263-274.
40. Kulkarni, A.B., and S. Karlsson. 1993. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am. J. Pathol. 143:3-9.
41. + T cells. J. Exp. Med. 178:237-244.
42. Rudolph, U., M.J. Finegold, S.S. Rich, G.R. Harriman, Y. Srinivasan, P. Brabet, G. Boulay, A. Bradley, and L. Birnbaumer. 1995. Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice. Nature Genet. 10:143-150.
43. Mombaerts, P., E. Mizoguchi, M.J. Grusby, L.H. Glimcher, A.K. Bhan, and S. Tonegawa. 1993. Spontaneous development of inflammatory disease in T cell receptor mutant mice. Cell. 75:274-282.
44. Sadlack, B., H. Merz, H. Schorle, A. Schimpi A. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:253-261.
45. Hollander, G.A., S.J. Simpson, E. Mizoguchi, A. Nichogiannopoulou, J. She, J.C. Guttierrez-Ramos, A.K. Bahn, S.J. Burakoff, B. Wang, and C. Terhorst. 1995. Severe colitis in mice with aberrant thymic selection. Immunity. 3:27-38.