Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome

Journal of the American Society of Nephrology

Volumn 10, Issue 11, 1999, Pages 2323-2331

  Nangaku, Masaomi ^a   Pippin, Jeff ^a   Couser, William G ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C6; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYCLINE; FIBRONECTIN; OSTEOPONTIN; PROTEIN; PUROMYCIN AMINONUCLEOSIDE; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY TUBULE CELL; MALE; NEPHROTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RAT;

EID: 0032711255     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Striker GE, Schainuck LI, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. I. A method for assaying and classifying histopathologic changes in renal disease. Hum Pathol 1: 615-630, 1970
2. Risdon RA, Sloper JAS, de Wardener H: Relations between renal function and histological changes found in renal biopsy specimens from patients with persistent glomerular nephritis. Lancet 2: 363-366, 1968
3. Bohle A, Wehrmann M, Bogenschutz O, Batz C, Vogl W, Schmitt H, Muller CA, Muller GA: The long-term prognosis of primary glomerulonephritis: A morphological and clinical analysis of 1747 cases. Pathol Res Pract 188: 908-924, 1992
4. Bohle A, Gise H, Mackensen-Haen S, Stark-Jacob B: The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Klin Wochenschr 59: 1043-1051, 1981
5. Bohle A, Mackensen-Haen S, von Gise H: Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution. Am J Nephrol 7: 421-433, 1987
6. Mackensen-Haen S, Bader R, Grund K, Bohle A: Correlations between renal cortical interstitial fibrosis, atrophy of proximal tubules and impairment of glomerular filtration rate. Clin Nephrol 15: 167-171, 1981
7. Schainuck LI, Striker GE, Cutler RE, Benditt EP, Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1: 631-641, 1970
8. Nath KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20: 1-17, 1992
9. Marcussen N: Atubular glomeruli and the structural basis for chronic renal failure. Lab Invest 66: 265-284, 1992
10. Gandhi M, Olson JL, Meyer TW: Contribution of tubular injury to loss of remnant kidney function. Kidney Int 54: 1157-1165, 1998
11. O'Dell JR, Hays RC, Guggenheim SJ, Steigerwald JC: Tubulo-interstitial renal disease in systemic lupus erythematosus. Arch Intern Med 145: 1996-1999, 1985
12. Katz A, Walker JF, Landy PJ: IgA nephritis with nephrotic range proteinuria. Clin Nephrol 20: 67-71, 1983
13. Croker BP, Dawson DV, Sanfilippo F: IgA nephropathy: Correlation of clinical and histologic features. Lab Invest 48: 19-24, 1983
14. Benigni A, Zoja C, Remuzzi G: Biology of disease: The renal toxicity of sustained glomerular protein traffic. Lab Invest 73: 461-466, 1995
15. Burton C, Harris KPG: The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 27: 765-775, 1996
16. Bruzzi I, Benigni A, Remuzzi G: Role of increased glomerular protein traffic in the progression of renal failure. Kidney Int 62[Suppl]: S29-S31, 1997
17. Remuzzi G, Bertani T: Pathophysiology of progressive nephropathies. N Engl J Med 339: 1448-1456, 1998
18. Eddy AA: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5: 1273-1287, 1994
19. Ledingham JG: Tubular toxicity of filtered proteins. Am J Nephrol 10[Suppl 1]: 52-57, 1990
20. Thomas ME, Schreiner GF: Contribution of proteinuria to progressive renal injury: Consequences of tubular uptake of fatty acid bearing albumin. Am J Nephrol 13: 385-398, 1993
21. Kees-Folts D, Sadow JL, Schreiner GF: Tubular catabolism of albumin is associated with the release of an inflammatory lipid. Kidney Int 4: 1697-1709, 1994
22. Alfrey AC, Froment DH, Hammond WS: Role of iron in the tubulo-interstitial injury in nephrotoxic serum nephritis, Kidney Int 36: 753-759, 1989
23. Howard RL, Buddington B, Alfrey AC: Urinary albumin, transferrin and iron excretion in diabetic patients. Kidney Int 40: 923-936, 1991
24. Camussi G, Rotunno M, Segoloni G, Brentjens JR, Andres GA: In vitro alternative pathway activation of complement by the brush border of proximal tubules of normal rat kidney. J Immunol 128: 1659-1663, 1982
25. Camussi G, Tetta C, Mazzucco G, Vercellone A: The brush border of proximal tubules of normal human kidney activates the alternative pathway of the complement system in vitro. Ann NY Acad Sci 420: 321-324, 1983
26. Baker PJ, Adler S, Yang Y, Couser WG: Complement activation by heat-killed human kidney cells: Formation, activity, and stabilization of cell-bound C3 convertases. J Immunol 133: 877-881, 1984
27. Nath KA, Hostetter MK, Hostetter TH: Pathophysiology of chronic tubulo-interstitial disease in rats: Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 76; 667-675, 1985
28. Khan TN, Sinniah R: Role of complement in renal tubular damage. Histopathology 26: 351-356, 1995
29. Eddy AA: Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135: 719-733, 1989
30. Alexopoulos E, Papaghianni A, Papadimitriou M: The pathogenetic significance of C5b-9 in IgA nephropathy. Nephrol Dial Transplant 10: 1166-1172, 1995
31. Biesecker G, Katz S, Koffler D: Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis. J Exp Med 154: 1779-1794, 1981
32. Hansch GM, Schieren G, Wagner C, Schonermark M: Immune damage to the mesangium: Antibody-and complement-mediated stimulation and destruction of mesangial cells. J Am Soc Nephrol 2: S139-S143, 1992
33. Hebert LA, Cosio FG, Birmingham DJ: The role of the complement system in renal injury. Semin Nephrol 12: 408-427, 1992
34. Couser WG: Pathogenesis of glomerular damage in glomerulonephritis. Nephrol Dial Transplant 13[Suppl 1]: 10-15, 1998
35. Couser WG: The pathogenesis of glomerulonephritis. Kidney Int 44: S19-S26, 1993
36. Brandt J, Pippin J, Schulze M, Mänsch GM, Alpers CE, Johnson RJ, Gordon K, Couser WG: Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int 49: 335-343, 1996
37. Schulze M, Baker PJ, Perkinson DT, Johnson RJ, Ochi RF, Stahl RAK, Couser WG: Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat. Kidney Int 35: 60-68, 1989
38. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Kurokawa K, Adler S, Morgan BP, Johnson RJ, Couser WG: CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats. J Am Soc Nephrol 9: 590-597, 1998
39. Butler BR: The Jaffe reaction: Identification of the coloured species. Clin Chim Acta 59: 227-232, 1975
40. Neilson RA, Jensen J, Gigli I, Tamura N: Methods for the separation, purification, and measurement of nine components of hemolytic complement in guinea pig serum. Immunohistochemistry 3: 111-135, 1966
41. Lange K, Wenk EJ: Complement components in the sera and urine of patients with severe proteinurias. Am J Med Sci 228: 448-453, 1954
42. Kjalman A, Avital A, Myers BD: Renal handling of the third (C3) and fourth (C4) components of the complement system in the nephrotic syndrome. Nephron 16: 333-343, 1976
43. Camussi G, Stratta P, Mazzucco G, Gaido M, Tetta C, Castello R, Rotunno M, Vercellone A: In vivo localization of C3 on the brush border of proximal tubules of kidneys from nephrotic patients. Clin Nephrol 23: 134-141, 1985
44. + transport in the kidney. Kidney Int 40[Suppl 33]: S95-S102, 1991
45. Clark EC, Nath KA, Hostetter MK, Hostetter TH: Role of ammonia in tubulointerstitial injury. Miner Electrolyte Metab 16: 315-321, 1990
46. Sato K, Ullrich KJ: Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. I. Mechanism of inhibition. Biochim Biophys Acta 343: 609-614, 1974
47. Morita Y, Nomura A, Yuzawa Y, Nishikawa K, Hotta N, Shimizu F, Matsuo S: The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis. J Am Soc Nephrol 8: 1363-1372, 1997
48. Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S: Role of complement in acute tubuloin-terstitial injury of rats with aminonucleoside nephrosis. Am J Pathol 151: 539-547, 1997
49. Grone H-J, Weber K, Grone E, Helmchen U, Osborn M: Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 129: 1-8, 1987
50. Eddy AA, McCulloch L, Liu E, Adams J: A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome. Am J Pathol 138: 1111-1123, 1991
51. Eddy AA, Giachelli CM: Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-over-load proteinuria. Kidney Int 41: 1546-1557, 1995
52. Magil AB: Tubulointerstitial lesions in young Zucker rats. Am J Kidney Dis 25: 478-485, 1995
53. Moll R, Hage C, Thoenes W: Expression of intermediate filament proteins in fetal and adult human kidney: Modulations of intermediate filament patterns during development and in damaged tissue. Lab Invest 65: 74-86, 1991
54. Giachelli CM, Schwartz SM, Liaw L: Molecular and cellular biology of osteopontin: Potential role in cardiovascular disease. Trends Cardiovasc Med 5: 88-95, 1995
55. Giachelli CM, Pichler R, Lombardi D, Denhardt DT, Alpers CE, Schwartz SM, Johnson RJ: Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 45: 515-524, 1994
56. Pichler RH, Franceschini N, Young BA, Hugo C, Andoh T, Burdmann E, Shankland SJ, Giachelli CM, Alpers CE, Bennett WM, Couser WG, Johnson RJ: Pathogenesis of cyclosporine nephropathy: Roles of angiotensin II and osteopontin. J Am Soc Nephrol 6: 1186-1196, 1995
57. Pichler RH, Giachelli CM, Lombardi D, Pippin J, Gordon K, Alpers CE, Schwartz SM, Johnson RJ: Tubulointerstitial disease in glomerulonephritis: Potential role of osteopontin (uropontin). Am J Pathol 144: 915-926, 1994
58. Diamond JR, Kees-Folts D, Ricardo SD, Pruznak A, Eufemio M: Early and persistent up-regulation of renal cortical osteopontin in experimental hydronephrosis. Am J Pathol 146: 1455-1466, 1995
59. Biancone L, David S, Pietra VD, Montrucchio G, Cambi V, Camussi G: Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney Int 45: 451-460, 1994
60. David S, Biancone L, Caserta C, Bussolati B, Cambi V, Camussi G: Alternative pathway complement activation induces proinflammatory activity in human proximal tubular epithelial cells. Nephrol Dial Transplant 12: 51-56, 1997
61. Hori Y, Yamada K, Hanafusa N, Okuda T, Okada N, Miyata T, Couser WG, Kurokawa K, Fujita T, Nangaku M: Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria in rats. Kidney Int 1999, in press
62. Ophascharoensuk V, Giachelli G, Gordon K, Hughes J, Pichler R, Brown P, Liaw L, Schmidt R, Shankland SJ, Alpers CE, Couser WG, Johnson RJ: Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis. Kidney Int 56: 571-580, 1999