Stereospecific toxicokinetics of bromochloro- and chlorofluoroacetate: Effect of GST-ζ depletion

Toxicology and Applied Pharmacology

Volumn 175, Issue 2, 2001, Pages 104-113

  Schultz, Irvin R ^a   Sylvester, Steven R ^b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

BCA; Chiral; Cytosol; GST CFA

Indexed keywords

ACETIC ACID DERIVATIVE; BROMOCHLOROACETATE; CHLOROFLUOROACETATE; DISINFECTANT AGENT; GLUTATHIONE TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL CARCINOGENESIS; ENZYME INHIBITION; MALE; NONHUMAN; RAT; WATER CONTAMINATION;

ANIMALIA; CELL FUSING AGENT VIRUS; RODENTIA;

EID: 0035449022     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9250     Document Type: Article

References (45)

1. Inactivation of glutathione transferase zeta by dichloroacetlc acid and other fluorine lacking alpha-haloalkanoic acids
2. Resolution of racemic chlorobromoacetic acid
3. Formation of the L-cysteineglyoxylate adduct is the mechanism by which L-cysteine decreases oxalate production from glycollate in rat hepatocytes
4. Influence of the drinking water disinfection by-product dibromoacetic acid on rat estrous cyclicity and ovarian follicular steroid release in vitro
5. Zeta, a novel class of glutathione transferases in a range of species from plants to humans
6. Identification, characterization, and crystal structure of the omega class glutathione transferases
7. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
8. In vivo clearance of ethoxycoumarin and its prediction from in vitro systems
9. Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: A potential unifying mechanism for its altered biotransformation and toxicity
10. Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses
11. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse
12. The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse
13. The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat
14. Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethlene metabolism
15. Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase
16. Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prolonged administration in drinking water
17. Effect of pretreatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetic of a subsequent challenge dose in B6C3F1 mice
18. Inhibition of metabolism by chlorinated and brominated di-haloacetates and differential recovery in B6C3F1 mice and F344 rats
19. Comparative effects of haloacetic acids in whole embryo culture
20. Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats
21. Pharmacokinetics and metabolism of [14]C dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate
22. The sperm biomarker S1722 is highly correlated with infertility resulting from the testicular toxicant bromochloroacetic acid
23. The occurrence of disinfection by-products in U.S. drinking water
24. Tissue distribution, excretion and urinary metabolites of dichloroacetic acid in the male fisher 344 rat
25. Dibromoacetic acid affects reproductive competence and sperm quality in the male rat
26. Histopathologic changes in the testes of rats exposed to dibromoacetic acid
27. Dichloroacetic acid: Metabolism in cytosol
28. Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration
29. Glutathione transferases-structure and catalytic activity
30. Characterization of a cytochrome P450 from di(2-ethylhexyl)phthalate-treated rats which hydroxylates fatty acids
31. Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice
32. In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfuram and diethyldithiocarbamate
33. Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity
34. Stereoselective conjugation of 2-bromocarboxylic acids and their urea derivatives by rat liver glutathione transferase 12-12 and some other isoforms
35. Chiral inversion and stereoselective glutathione conjugation of the four 2-bromo-3-methylvaleric acid stereoisomers in the rat in vivo and in vitro
36. Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats
37. Adduction of hemoglobin and albumin in vivo by metabolites of trichloroethylene, trichloroacetate, and dichloroacetate in rats and mice
38. Glutathione transferase zeta catalyzes the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid
39. Glutathione transferase zeta catalyzed biotransformation of dichloroacetic acid and other α-halo-acids
40. Polymorphism and species-dependent inactivation of glutathione transferase zeta by dichloroacetate
41. Stereoselective biotransformation: Toxicological consequences and implications
42. Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids
43. Metabolism of bromodichloroacetate in B6C3F1 mice