XTrR-I is a TGFβ receptor and overexpression of a truncated form of the receptor inhibits axis formation and dorsalising activity

Mechanisms of Development

Volumn 75, Issue 1-2, 1998, Pages 95-105

  Mahony, D ^a,b   Weis, F M B ^c   Massague J ^c   Gurdon, J B ^a,b  

^a WELLCOME CRC INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Mesoderm; Siamois; Xenopus

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; ACTIVIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; INHIBIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; XTRR I RECEPTOR; XTRR-I RECEPTOR;

AMPHIBIA; BLASTULA; CELL DIFFERENTIATION; CHROMOSOME NOR; EMBRYO DEVELOPMENT; GASTRULATION; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR DENSITY; RECEPTOR UPREGULATION; REVIEW; ANIMAL; ANIMAL EMBRYO; ARTICLE; CHEMISTRY; DRUG EFFECT; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM; MORPHOGENESIS; MUSCLE; MUTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; XENOPUS;

AMPHIBIA; ANIMALIA; VERTEBRATA;

ACTIVINS; ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; EMBRYO, NONMAMMALIAN; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INHIBINS; MESODERM; MUSCLES; MUTATION; NOTOCHORD; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; XENOPUS;

EID: 0032107262     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00092-6     Document Type: Article

References (62)

1. Amaya E., Musci T.J., Kirschner M.W. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell. 66:1991;257-270.
2. Asashima M., Nakano H., Shimada K., Kinoshita K., Ishii K., Shibai H., Ueno N. Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). Roux's Arch. Dev. Biol. 198:1990;330-335.
3. Bassing C.H., Yingling J.M., Howe D.J., Wang T., He W.W., Gustafson M.L., Shah P., Donahoe P.K., Wang X.-F. A transforming growth factor β type I receptor that signals to activate gene expression. Science. 263:1994;87-89.
4. Boyd F.T., Massagué J. Growth inhibitory response to transforming growth factor-b linked to expression of a 53 kDa cell surface TGF-β receptor. J. Biol. Chem. 264:1989;2272-2278.
5. Carcamo J., Weis F.M.B., Ventura F., Wieser R., Wrana J.L., Attisano L., Massagué J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol. Cell Biol. 14:1994;3810-3821.
6. Cheifetz S., Hernandez H., Laiho M., tenDijke P., Iwata K.K., Massagué J. Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms. J. Biol. Chem. 265:1990;20533-20538.
7. Chen Y.G., Liu F., Massagué J. Mechanism of TGFβ receptor inhibition by FKBP12. EMBO J. 16:1997;3866-3876.
8. Dale L., Matthews G., Colman A. Secretion and mesoderm inducing activity of the TGFβ related domain of Xenopus vg1. EMBO J. 12:1993;4471-4480.
9. Dawid I.B. Mesoderm induction. Methods Cell Biol. 36:1991;311-328.
10. De Robertis E.M., Sasai Y. A common plan for dorsoventral patterning in Bilateria. Nature. 380:1996;37-40.
11. Franzen P., ten Dijke P., Ichijo H., Yamashita H., Schulz P., Heldin C.-H., Miyazono K. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell. 75:1993;681-692.
12. Gawantka V., Delius H., Hirschfeld K., Blumenstock C., Niehrs C. Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. EMBO J. 14:1995;6268-6279.
13. Graff M.J., Thies R.S., Song J.J., Celeste A.J., Melton D.A. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell. 79:1994;169-179.
14. Green J.B., Smith J.C., Gerhart J.C. Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern. Development. 120:1994;2271-2278.
15. Gurdon J.B., Fairman S., Mohun T.J., Brennan S. Activation of muscle-specific actin genes in Xenopus developments by an induction between animal and vegetal cells of a blastula. Cell. 41:1985;913-922.
16. Gurdon J.B., Tiller E., Roberts J., Kato K. A community effect in muscle development. Curr. Biol. 3:1993;1-11.
17. Hemmati-Brivanlou A., Melton D.A. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 359:1992;609-614.
18. Hogan B.L.M. Bone morphogenetic proteins in development. Curr. Opin. Gen. Dev. 6:1996;432-438.
19. Holley S.A., Neul J.L., Attisano L., Wrana J.L., Sasai Y., O'Connor M.B., De Robertis E.M., Ferguson E.L. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell. 86:1996;607-617.
20. Jones C.M., Dale L., Hogan B.L., Wright C.V., Smith J.C. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development. 122:1996;1545-1554.
21. Jones C.M., Kuehn M.R., Hogan B.L., Smith J.C., Wright C.V. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development. 121:1995;3651-3662.
22. Jones E.A., Woodland H.R. The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm. Development. 101:1987;557-563.
23. Kato K., Gurdon J.B. Single-cell transplantation determines the time when Xenopus muscle precursor cells acquire a capacity for autonomous differentiation. Proc. Natl. Acad. Sci. (USA). 90:1993;1310-1314.
24. Kimelman D., Kirschner M. Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell. 51:1987;869-877.
25. Kingsley, D.M., 1994. The TGF-β superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev 8, 133-146.
26. Kintner C.J., Brockes J.P. Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration. Nature. 308:1984;67-69.
27. Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Ryutaro Y., Muramatsu M., Shiokawa K. Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of expression affects the body axis formation. Biochem Biophys. Res. Commun. 181:1991;684-690.
28. Krieg P.A., Melton D.A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucl. Acids Res. 12:1984;7057-7070.
29. Laiho M., Weis F.M.B., Massagué J. Concomitant loss of transforming growth factor-β receptor types I and II in cell mutants resistant to TGF-β J. Biol. Chem. 265:1990;18158-18524.
30. Lemaire P., Garrett N., Gurdon J.B. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell. 81:1995;85-94.
31. Lemaire P., Gurdon J.B. A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos. Development. 120:1994;1191-1199.
32. Lettice L.A., Slack J.M.W. Properties of the dorsalizing signal in gastrulae of Xenopus laevis. Development. 117:1993;263-272.
33. Liu F., Ventura F., Doody J., Massagué J. Human Type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol. Cell Biol. 15:1995;3479-3486.
34. Maeno M., Ong R.C., Suxuki A., Ueno N., Kung H.-F. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. Proc. Natl. Acad. Sci. (USA). 91:1994;10260-10264.
35. Mahony D., Gurdon J.B. A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus. Proc. Natl. Acad. Sci. (USA). 92:1995;6474-6478.
36. Massagué J. Identification of receptors of type β transforming growth factor. Methods Enzymol. 146:1987;174-195.
37. Massagué J., Attisano L., Wrana J.L. The TGF-β family and its composite receptors. Trends Cell Biol. 4:1994;172-178.
38. Massagué J. TGFb signaling: receptors, transducers, and mad proteins. Cell. 85:1996;947-950.
39. Mathews L.S., Vale W.W., Kintner C.R. Cloning of a second type of activin receptor and functional characterization in Xenopus embryos. Science. 255:1992;1702-1705.
40. Melton D.A. Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes. Nature. 328:1987;80-82.
41. Moos M., Wang S., Krinks M. Anti-dorsalizing morphogenetic protein is a novel TGF-β homolog expressed in the Spemann organizer. Development. 121:1995;4293-4301.
42. Nieuwkoop P.D. The formation of mesoderm in Urodelean amphibians. I. Induction by the endoderm. Roux's Arch. Entwicklungsmech. Org. 162:1969;341-373.
43. Onichtchouk D., Gawantka V., Dosch R., Delius H., Hirschfeld K., Blumenstock C., Niehrs C. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling dorsoventral patterning of Xenopus mesoderm. Development. 122:1996;3045-3053.
44. Piccolo S., Sasai Y., Lu B., De Robertis E.M. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 86:1996;589-598.
45. Rosa F., Roberts A.B., Danielpour D., Dart L.D., Sport M.B., Dawid I.B. Mesoderm induction in amphibians: the role of TGF-82-like factors. Science. 239:1988;783-785.
46. Sasai Y., Lu B., Steinbesser H., Geissert D., Gont L.K., De Robertis E.M. Xenopus chordin, a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell. 79:1994;779-790.
47. Slack J.M.W. Inducing factors in Xenopus early embryos. Curr. Biol. 4:1994;116-126.
48. Slack, J.M.W., Darlington, B.G., Gillespie, L.L., Godsave, S.F., Isaacs, H.V., Paterno, G.D., 1989. The role of fibroblast growth factor in early Xenopus development. Development (Suppl.) 141-148.
49. Smith J.C., Price B.M.J., Green J.B.A., Weigel D., Herrmann B.G. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell. 67:1991;79-87.
50. Smith J.C., Price B.M.J., Van Nimmen K., Huylebroeck D. Identification of a potent Xenopus mesoderm-inducing factor as a homolog of activin A. Nature. 345:1990;729-731.
51. Smith J.C., Watt F.M. Biochemical specificity of Xenopus notochord. Development. 29:1985;109-115.
52. Smith W.C., Harland R.M. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell. 67:1991;753-765.
53. Smith W.C., Harland R.M. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell. 70:1992;829-840.
54. Smith W.C., McKendry R., Ribisi S., Harland R.M. A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell. 82:1995;37-46.
55. Sokol S., Christian J.L., Moon R.T., Melton D.A. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell. 67:1991;741-752.
56. Spemann H., Mangold H. Uber Induktion von Embronalanlagen durch Implantation Artfremder Organisatoren. Roux's Arch. Entw. Mech. 100:1924;599-638.
57. Thomsen G.H., Melton D.A. Processed vg-1 protein is an axial inducer in Xenopus. Cell. 74:1993;433-441.
58. Wilson P.A., Melton D.A. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communications. Curr. Biol. 4:1994;676-686.
59. Wrana J.L., Attisano L., Carcamo J., Zentella A., Doody J., Laiho M., Wang X.F., Massagué J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell. 71:1992;1003-1014.
60. Wrana J.L., Attisano L., Wieser R., Ventura F., Massagué J. Mechanism of activation of the TGF-β receptor. Nature. 370:1994;341-347.
61. Zhou X., Sasaki H., Lowe L., Hogan B.L., Kuehn M.R. Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation. Nature. 361:1993;543-547.
62. Zimmerman L.B., De Jesus-Escobar J.M., Harland R.M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 86:1996;599-606.