-
1
-
-
0026874127
-
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
-
Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874, 1992.
-
(1992)
Crit Care Med
, vol.20
, pp. 864-874
-
-
-
2
-
-
0020517209
-
Multiple organ failure in poly-trauma patients
-
Faist EA, Baue E, Dittmer H, et al.: Multiple organ failure in poly-trauma patients. J Trauma 23:775-787, 1983.
-
(1983)
J Trauma
, vol.23
, pp. 775-787
-
-
Faist, E.A.1
Baue, E.2
Dittmer, H.3
-
3
-
-
0020582589
-
Natural history of major bums with multiple subsystem failure
-
Marshall Wu, Dimick AR: Natural history of major bums with multiple subsystem failure. J Trauma 23:102-105, 1983.
-
(1983)
J Trauma
, vol.23
, pp. 102-105
-
-
Marshall, W.1
Dimick, A.R.2
-
4
-
-
0027434109
-
Multiple organ failure in patients with thermal injury
-
Saffle JR, Sullivan JJ, Tuohig GM, et al.: Multiple organ failure in patients with thermal injury. Crit Care Med 21:1673-1683, 1993.
-
(1993)
Crit Care Med
, vol.21
, pp. 1673-1683
-
-
Saffle, J.R.1
Sullivan, J.J.2
Tuohig, G.M.3
-
5
-
-
0023215839
-
Clinical analysis of multiple organ failure in burned patients
-
Aikowa N, Shinozawa Y, Ishibiki K: Clinical analysis of multiple organ failure in burned patients. Burns 13:103-109, 1987.
-
(1987)
Burns
, vol.13
, pp. 103-109
-
-
Aikowa, N.1
Shinozawa, Y.2
Ishibiki, K.3
-
6
-
-
0023413514
-
Incidence of necrotizing pancreatitis and factors related to mortality
-
Allardyce DB: Incidence of necrotizing pancreatitis and factors related to mortality. Am J Surg 154:295-299, 1987.
-
(1987)
Am J Surg
, vol.154
, pp. 295-299
-
-
Allardyce, D.B.1
-
7
-
-
0021054632
-
Multiple system failure and circulatory support
-
Baue AE, Guthrie D: Multiple system failure and circulatory support. Jpn J Surg 13:69-85, 1983.
-
(1983)
Jpn J Surg
, vol.13
, pp. 69-85
-
-
Baue, A.E.1
Guthrie, D.2
-
8
-
-
0026744448
-
Multiple organ failure
-
Deitch EA: Multiple organ failure. Ann Surg 216:117-134, 1992.
-
(1992)
Ann Surg
, vol.216
, pp. 117-134
-
-
Deitch, E.A.1
-
10
-
-
0025883342
-
Nitric oxide: Physiology, pathophysiology and pharmacology
-
Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142, 1991.
-
(1991)
Pharmacol Rev
, vol.43
, pp. 109-142
-
-
Moncada, S.1
Palmer, R.M.J.2
Higgs, E.A.3
-
11
-
-
0026629902
-
Nitric oxide as a secretory product of mammalian cells
-
Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064, 1996.
-
(1996)
FASEB J
, vol.6
, pp. 3051-3064
-
-
Nathan, C.1
-
12
-
-
0029437225
-
Reactions between nitric oxide, superoxide, and peroxynitrite: Footprints of peroxynitrite in vivo
-
Crow JP, Beckman JS: Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo. Adv Pharmacol 34:17-43, 1995.
-
(1995)
Adv Pharmacol
, vol.34
, pp. 17-43
-
-
Crow, J.P.1
Beckman, J.S.2
-
13
-
-
0029037495
-
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
-
Pryor W, Squadrito G: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L772, 1995.
-
(1995)
Am J Physiol
, vol.268
-
-
Pryor, W.1
Squadrito, G.2
-
14
-
-
0025189864
-
Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
-
Beckman JS, Beckman TW, Chen J, et al.: Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624, 1990.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 1620-1624
-
-
Beckman, J.S.1
Beckman, T.W.2
Chen, J.3
-
15
-
-
0028670471
-
Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart
-
Villa LM, Salas E, Darley-Usmar M, et al.: Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci USA 91:12383-12387, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12383-12387
-
-
Villa, L.M.1
Salas, E.2
Darley-Usmar, M.3
-
16
-
-
0028879567
-
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
-
Miller MJS, Thompson JH, Zhang XJ, et al.: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109:1475-1483, 1995.
-
(1995)
Gastroenterology
, vol.109
, pp. 1475-1483
-
-
Miller, M.J.S.1
Thompson, J.H.2
Zhang, X.J.3
-
17
-
-
0031033903
-
The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock
-
Zingarelli B, Day BJ, Crapo J, et al.: The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br J Pharmacol 120:259-267, 1997.
-
(1997)
Br J Pharmacol
, vol.120
, pp. 259-267
-
-
Zingarelli, B.1
Day, B.J.2
Crapo, J.3
-
18
-
-
0028805211
-
TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C
-
Phelps DT, Ferro TJ, Higgins PJ, et al.: TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am J Physiol 269:L551-L559, 1995.
-
(1995)
Am J Physiol
, vol.269
-
-
Phelps, D.T.1
Ferro, T.J.2
Higgins, P.J.3
-
19
-
-
0029111530
-
Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
-
Inoue S, Kawanishi S: Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett 371:86-88, 1995.
-
(1995)
FEBS Lett
, vol.371
, pp. 86-88
-
-
Inoue, S.1
Kawanishi, S.2
-
20
-
-
0029145358
-
DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes
-
Salgo MG, Bermudez E, Squadrito G, Pryor W: DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch Biochem Biophys 322:500-505, 1995.
-
(1995)
Arch Biochem Biophys
, vol.322
, pp. 500-505
-
-
Salgo, M.G.1
Bermudez, E.2
Squadrito, G.3
Pryor, W.4
-
21
-
-
0030026515
-
Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
-
Zingarelli B, O'Connor M, Wong H, et al.: Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156:350-358, 1996.
-
(1996)
J Immunol
, vol.156
, pp. 350-358
-
-
Zingarelli, B.1
O'Connor, M.2
Wong, H.3
-
22
-
-
0026637297
-
Oxygen-radicals in experimental shock: Effects of spin-trapping nitrones in ameliorating shock pathophysiology
-
Novelli GP: Oxygen-radicals in experimental shock: effects of spin-trapping nitrones in ameliorating shock pathophysiology. Crit Care Med 20:499-507, 1992.
-
(1992)
Crit Care Med
, vol.20
, pp. 499-507
-
-
Novelli, G.P.1
-
23
-
-
0032738667
-
Beneficial effects of Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock
-
Cuzzocrea S, Costantino G, Mazzon E, et al.: Beneficial effects of Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock. Br J Pharmacol 128:1241-1251, 1999.
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1241-1251
-
-
Cuzzocrea, S.1
Costantino, G.2
Mazzon, E.3
-
24
-
-
0032838589
-
Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat
-
Cuzzocrea S, Costantino G, Mazzon E, Caputi AP: Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat. Crit Care Med 27:1524-1532, 1999.
-
(1999)
Crit Care Med
, vol.27
, pp. 1524-1532
-
-
Cuzzocrea, S.1
Costantino, G.2
Mazzon, E.3
Caputi, A.P.4
-
25
-
-
0028999596
-
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
-
MacMicking JD, Nathan C, Horn G, Chartrain N, Fletcher DS, Trumbauer M, et al.: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995.
-
(1995)
Cell
, vol.81
, pp. 641-650
-
-
MacMicking, J.D.1
Nathan, C.2
Horn, G.3
Chartrain, N.4
Fletcher, D.S.5
Trumbauer, M.6
-
26
-
-
0032737345
-
Role of interleukin-6 in local inflammation
-
Cuzzocrea S, Sautebin L, De Sarro GB, et al.: Role of interleukin-6 in local inflammation J Immunol 163:5094-5104, 1999.
-
(1999)
J Immunol
, vol.163
, pp. 5094-5104
-
-
Cuzzocrea, S.1
Sautebin, L.2
De Sarro, G.B.3
-
27
-
-
0032061048
-
Peroxynitrate-mediated dna strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a non-septic shock model induced by zymosan in the rat
-
Cuzzocrea S, Zingarelli B, Caputi AP: Peroxynitrate-mediated DNA strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a non-septic shock model induced by zymosan in the rat. Shock 9:336-340, 1998.
-
(1998)
Shock
, vol.9
, pp. 336-340
-
-
Cuzzocrea, S.1
Zingarelli, B.2
Caputi, A.P.3
-
28
-
-
0030133352
-
Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
-
Darley-Usmar V, Halliwell B: Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmaceut Res 13:649, 1996.
-
(1996)
Pharmaceut Res
, vol.13
, pp. 649
-
-
Darley-Usmar, V.1
Halliwell, B.2
-
29
-
-
0021998590
-
Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
-
Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167, 1985.
-
(1985)
J Pharmacol Methods
, vol.14
, pp. 157-167
-
-
Mullane, K.M.1
Kraemer, R.2
Smith, B.3
-
30
-
-
0018384650
-
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
-
Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979.
-
(1979)
Anal Biochem
, vol.95
, pp. 351-358
-
-
Ohkawa, H.1
Ohishi, N.2
Yagi, K.3
-
31
-
-
0019524365
-
Multiple systems organ failure: The basal state
-
McMenamy RH, Birkhahn R, Oswald G, et al.: Multiple systems organ failure: the basal state. J Trauma 21:99-114, 1981.
-
(1981)
J Trauma
, vol.21
, pp. 99-114
-
-
McMenamy, R.H.1
Birkhahn, R.2
Oswald, G.3
-
32
-
-
0023232442
-
Hypermetabolism, organ failure, and metabolic support
-
Cerra FB: Hypermetabolism, organ failure, and metabolic support. Surgery 101:1-14, 1987.
-
(1987)
Surgery
, vol.101
, pp. 1-14
-
-
Cerra, F.B.1
-
33
-
-
0024852805
-
Neutrophil function and lipid peroxidation in a rat model of multiple organ failure
-
Van Bebber IPT, Boekholtz WKF, Goris R JA, et al.: Neutrophil function and lipid peroxidation in a rat model of multiple organ failure. J Surg Res 47:471, 1989.
-
(1989)
J Surg Res
, vol.47
, pp. 471
-
-
Van Bebber, I.P.T.1
Boekholtz, W.K.F.2
Goris, R.J.A.3
-
34
-
-
0028151406
-
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: Formation of novel nitrogen-containing oxidized lipid derivatives
-
Rubbo H, Radi R, Trujillo M, et al.: Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269:26066-26075, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 26066-26075
-
-
Rubbo, H.1
Radi, R.2
Trujillo, M.3
-
35
-
-
0027162279
-
Peroxynitrite modification of low density lipoprotein leads to recognition by the macrophage scavenger receptor
-
Graham A, Hogg N, Kalyanaraman B, et al.: Peroxynitrite modification of low density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett 330:18-25, 1993.
-
(1993)
FEBS Lett
, vol.330
, pp. 18-25
-
-
Graham, A.1
Hogg, N.2
Kalyanaraman, B.3
-
36
-
-
0001226142
-
Nitric oxide in cells
-
Lancaster JR: Nitric oxide in cells. Am Sci 80:248-255, 1992.
-
(1992)
Am Sci
, vol.80
, pp. 248-255
-
-
Lancaster, J.R.1
-
37
-
-
0028507906
-
Comparison between lung and liver peroxidation and mortality after zymosan peritonitis in the rats
-
Demling R, Nayak U, Ikegami K, et al.: Comparison between lung and liver peroxidation and mortality after zymosan peritonitis in the rats. Shock 2:222-227, 1994.
-
(1994)
Shock
, vol.2
, pp. 222-227
-
-
Demling, R.1
Nayak, U.2
Ikegami, K.3
-
38
-
-
0029366301
-
The gut a cytokine-generating organ in systemic inflammation?
-
Mainous MR, Ertel W, Chaudry IH: The gut a cytokine-generating organ in systemic inflammation? Shock 4:193-199, 1995.
-
(1995)
Shock
, vol.4
, pp. 193-199
-
-
Mainous, M.R.1
Ertel, W.2
Chaudry, I.H.3
-
39
-
-
0031253810
-
Multiple organ failure following zymosan-induced peritonitis is mediated by nitric oxide
-
Cuzzocrea S, Zingarelli B, Sautebin L, et al.: Multiple organ failure following zymosan-induced peritonitis is mediated by nitric oxide. Shock 4:268-275, 1997.
-
(1997)
Shock
, vol.4
, pp. 268-275
-
-
Cuzzocrea, S.1
Zingarelli, B.2
Sautebin, L.3
-
40
-
-
0033072371
-
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat
-
Cuzzocrea S, Costantino G, Caputi AP: Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat. Shock 11:143-148, 1999.
-
(1999)
Shock
, vol.11
, pp. 143-148
-
-
Cuzzocrea, S.1
Costantino, G.2
Caputi, A.P.3
-
41
-
-
0031136492
-
Role of nitric oxide in a non-septic shock model induced by zymosan in the rat
-
Cuzzocrea S, Filippelli A, Zingarelli B, et al.: Role of nitric oxide in a non-septic shock model induced by zymosan in the rat. Shock 7:351-358, 1997.
-
(1997)
Shock
, vol.7
, pp. 351-358
-
-
Cuzzocrea, S.1
Filippelli, A.2
Zingarelli, B.3
-
42
-
-
0029065134
-
The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat
-
Tracey WR, Nakane M, Kuk J, et al.: The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J Pharmacol Exp Ther 273:1295-1299, 1995.
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 1295-1299
-
-
Tracey, W.R.1
Nakane, M.2
Kuk, J.3
-
43
-
-
0029035476
-
Altered immune responses in mice lacking inducible nitric oxide synthase
-
Wei XQ, Charles IG, Smith A, et al.: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411, 1995.
-
(1995)
Nature
, vol.375
, pp. 408-411
-
-
Wei, X.Q.1
Charles, I.G.2
Smith, A.3
-
44
-
-
0029763960
-
Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation
-
Salvemini D, Wang ZQ, Wyatt P, Bourdon DM, et al.: Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 118:829-838, 1996.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 829-838
-
-
Salvemini, D.1
Wang, Z.Q.2
Wyatt, P.3
Bourdon, D.M.4
-
45
-
-
0031742316
-
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation
-
Ajuebor MN, Virag L, Flower RJ, et al.: Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology 95:625-630, 1998.
-
(1998)
Immunology
, vol.95
, pp. 625-630
-
-
Ajuebor, M.N.1
Virag, L.2
Flower, R.J.3
-
46
-
-
0032057735
-
Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthetase
-
Zingarelli B, Viràg L, Szabò A, et al.: Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthetase. Int J Mol Med 1:787-795, 1998.
-
(1998)
Int J Mol Med
, vol.1
, pp. 787-795
-
-
Zingarelli, B.1
Viràg, L.2
Szabò, A.3
-
47
-
-
0031975261
-
Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
-
Cuzzocrea S, Zingarelli B, Gilard E, et al.: Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Rad Biol Med 24:450-459, 1998.
-
(1998)
Free Rad Biol Med
, vol.24
, pp. 450-459
-
-
Cuzzocrea, S.1
Zingarelli, B.2
Gilard, E.3
-
48
-
-
0029148018
-
Peroxynitrite-mediated oxidation of dihydrorhoramine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury
-
Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhoramine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372:229-232, 1995.
-
(1995)
FEBS Lett
, vol.372
, pp. 229-232
-
-
Szabó, C.1
Salzman, A.L.2
Ischiropoulos, H.3
-
49
-
-
0028969011
-
Evidence for in vivo peroxynitrite production in human acute lung injury
-
Kooy NW, Royall JA, Ye YZ, et al.: Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 151:1250-1254, 1995.
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1250-1254
-
-
Kooy, N.W.1
Royall, J.A.2
Ye, Y.Z.3
-
50
-
-
0029682870
-
Oxidative damage and tyrosine nitration from peroxynitrite
-
Beckman JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836-844, 1996.
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 836-844
-
-
Beckman, J.S.1
-
51
-
-
0032556905
-
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
-
Eiserich JP, Hristova M, Cross CE, et al.: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391:393-397, 1998.
-
(1998)
Nature
, vol.391
, pp. 393-397
-
-
Eiserich, J.P.1
Hristova, M.2
Cross, C.E.3
-
52
-
-
0032584164
-
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase
-
Szabó C, Viràg L, Cuzzocrea S, et al.: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase. Proc Natl Acad Sci USA 95:3867-3872, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3867-3872
-
-
Szabó, C.1
Viràg, L.2
Cuzzocrea, S.3
-
53
-
-
0030870278
-
Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment
-
Szabó C, Lim LHK, Cuzzocrea S, et al.: Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J Exp Med 186:1041-1049, 1997.
-
(1997)
J Exp Med
, vol.186
, pp. 1041-1049
-
-
Szabó, C.1
Lim, L.H.K.2
Cuzzocrea, S.3
-
54
-
-
0032818362
-
Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat
-
Cuzzocrea S, Zingarelli B, Costantino G, et al.: Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat. Crit Care Med 27:1517-1523, 1999.
-
(1999)
Crit Care Med
, vol.27
, pp. 1517-1523
-
-
Cuzzocrea, S.1
Zingarelli, B.2
Costantino, G.3
|