메뉴 건너뛰기




Volumn 16, Issue 1, 2001, Pages 51-58

Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan

Author keywords

Free radicals; Inflammation; iNOS; Peroxynitrite; Zymosan

Indexed keywords

3 NITROTYROSINE; 3-NITROTYROSINE; AMINOGUANIDINE; DRUG DERIVATIVE; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; NOS2 PROTEIN, MOUSE; PEROXIDASE; RHODAMINE; TYROSINE; ZYMOSAN;

EID: 0035403680     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200116010-00010     Document Type: Article
Times cited : (53)

References (54)
  • 1
    • 0026874127 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874, 1992.
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 2
    • 0020517209 scopus 로고
    • Multiple organ failure in poly-trauma patients
    • Faist EA, Baue E, Dittmer H, et al.: Multiple organ failure in poly-trauma patients. J Trauma 23:775-787, 1983.
    • (1983) J Trauma , vol.23 , pp. 775-787
    • Faist, E.A.1    Baue, E.2    Dittmer, H.3
  • 3
    • 0020582589 scopus 로고
    • Natural history of major bums with multiple subsystem failure
    • Marshall Wu, Dimick AR: Natural history of major bums with multiple subsystem failure. J Trauma 23:102-105, 1983.
    • (1983) J Trauma , vol.23 , pp. 102-105
    • Marshall, W.1    Dimick, A.R.2
  • 4
    • 0027434109 scopus 로고
    • Multiple organ failure in patients with thermal injury
    • Saffle JR, Sullivan JJ, Tuohig GM, et al.: Multiple organ failure in patients with thermal injury. Crit Care Med 21:1673-1683, 1993.
    • (1993) Crit Care Med , vol.21 , pp. 1673-1683
    • Saffle, J.R.1    Sullivan, J.J.2    Tuohig, G.M.3
  • 5
    • 0023215839 scopus 로고
    • Clinical analysis of multiple organ failure in burned patients
    • Aikowa N, Shinozawa Y, Ishibiki K: Clinical analysis of multiple organ failure in burned patients. Burns 13:103-109, 1987.
    • (1987) Burns , vol.13 , pp. 103-109
    • Aikowa, N.1    Shinozawa, Y.2    Ishibiki, K.3
  • 6
    • 0023413514 scopus 로고
    • Incidence of necrotizing pancreatitis and factors related to mortality
    • Allardyce DB: Incidence of necrotizing pancreatitis and factors related to mortality. Am J Surg 154:295-299, 1987.
    • (1987) Am J Surg , vol.154 , pp. 295-299
    • Allardyce, D.B.1
  • 7
    • 0021054632 scopus 로고
    • Multiple system failure and circulatory support
    • Baue AE, Guthrie D: Multiple system failure and circulatory support. Jpn J Surg 13:69-85, 1983.
    • (1983) Jpn J Surg , vol.13 , pp. 69-85
    • Baue, A.E.1    Guthrie, D.2
  • 8
    • 0026744448 scopus 로고
    • Multiple organ failure
    • Deitch EA: Multiple organ failure. Ann Surg 216:117-134, 1992.
    • (1992) Ann Surg , vol.216 , pp. 117-134
    • Deitch, E.A.1
  • 10
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology and pharmacology
    • Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142, 1991.
    • (1991) Pharmacol Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.J.2    Higgs, E.A.3
  • 11
    • 0026629902 scopus 로고    scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064, 1996.
    • (1996) FASEB J , vol.6 , pp. 3051-3064
    • Nathan, C.1
  • 12
    • 0029437225 scopus 로고
    • Reactions between nitric oxide, superoxide, and peroxynitrite: Footprints of peroxynitrite in vivo
    • Crow JP, Beckman JS: Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo. Adv Pharmacol 34:17-43, 1995.
    • (1995) Adv Pharmacol , vol.34 , pp. 17-43
    • Crow, J.P.1    Beckman, J.S.2
  • 13
    • 0029037495 scopus 로고
    • The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
    • Pryor W, Squadrito G: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L772, 1995.
    • (1995) Am J Physiol , vol.268
    • Pryor, W.1    Squadrito, G.2
  • 14
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, et al.: Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3
  • 15
    • 0028670471 scopus 로고
    • Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart
    • Villa LM, Salas E, Darley-Usmar M, et al.: Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci USA 91:12383-12387, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12383-12387
    • Villa, L.M.1    Salas, E.2    Darley-Usmar, M.3
  • 16
    • 0028879567 scopus 로고
    • Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
    • Miller MJS, Thompson JH, Zhang XJ, et al.: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109:1475-1483, 1995.
    • (1995) Gastroenterology , vol.109 , pp. 1475-1483
    • Miller, M.J.S.1    Thompson, J.H.2    Zhang, X.J.3
  • 17
    • 0031033903 scopus 로고    scopus 로고
    • The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock
    • Zingarelli B, Day BJ, Crapo J, et al.: The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br J Pharmacol 120:259-267, 1997.
    • (1997) Br J Pharmacol , vol.120 , pp. 259-267
    • Zingarelli, B.1    Day, B.J.2    Crapo, J.3
  • 18
    • 0028805211 scopus 로고
    • TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C
    • Phelps DT, Ferro TJ, Higgins PJ, et al.: TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am J Physiol 269:L551-L559, 1995.
    • (1995) Am J Physiol , vol.269
    • Phelps, D.T.1    Ferro, T.J.2    Higgins, P.J.3
  • 19
    • 0029111530 scopus 로고
    • Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
    • Inoue S, Kawanishi S: Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett 371:86-88, 1995.
    • (1995) FEBS Lett , vol.371 , pp. 86-88
    • Inoue, S.1    Kawanishi, S.2
  • 20
    • 0029145358 scopus 로고
    • DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes
    • Salgo MG, Bermudez E, Squadrito G, Pryor W: DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch Biochem Biophys 322:500-505, 1995.
    • (1995) Arch Biochem Biophys , vol.322 , pp. 500-505
    • Salgo, M.G.1    Bermudez, E.2    Squadrito, G.3    Pryor, W.4
  • 21
    • 0030026515 scopus 로고    scopus 로고
    • Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
    • Zingarelli B, O'Connor M, Wong H, et al.: Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156:350-358, 1996.
    • (1996) J Immunol , vol.156 , pp. 350-358
    • Zingarelli, B.1    O'Connor, M.2    Wong, H.3
  • 22
    • 0026637297 scopus 로고
    • Oxygen-radicals in experimental shock: Effects of spin-trapping nitrones in ameliorating shock pathophysiology
    • Novelli GP: Oxygen-radicals in experimental shock: effects of spin-trapping nitrones in ameliorating shock pathophysiology. Crit Care Med 20:499-507, 1992.
    • (1992) Crit Care Med , vol.20 , pp. 499-507
    • Novelli, G.P.1
  • 23
    • 0032738667 scopus 로고    scopus 로고
    • Beneficial effects of Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock
    • Cuzzocrea S, Costantino G, Mazzon E, et al.: Beneficial effects of Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock. Br J Pharmacol 128:1241-1251, 1999.
    • (1999) Br J Pharmacol , vol.128 , pp. 1241-1251
    • Cuzzocrea, S.1    Costantino, G.2    Mazzon, E.3
  • 24
    • 0032838589 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat
    • Cuzzocrea S, Costantino G, Mazzon E, Caputi AP: Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat. Crit Care Med 27:1524-1532, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 1524-1532
    • Cuzzocrea, S.1    Costantino, G.2    Mazzon, E.3    Caputi, A.P.4
  • 25
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking JD, Nathan C, Horn G, Chartrain N, Fletcher DS, Trumbauer M, et al.: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995.
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.D.1    Nathan, C.2    Horn, G.3    Chartrain, N.4    Fletcher, D.S.5    Trumbauer, M.6
  • 26
    • 0032737345 scopus 로고    scopus 로고
    • Role of interleukin-6 in local inflammation
    • Cuzzocrea S, Sautebin L, De Sarro GB, et al.: Role of interleukin-6 in local inflammation J Immunol 163:5094-5104, 1999.
    • (1999) J Immunol , vol.163 , pp. 5094-5104
    • Cuzzocrea, S.1    Sautebin, L.2    De Sarro, G.B.3
  • 27
    • 0032061048 scopus 로고    scopus 로고
    • Peroxynitrate-mediated dna strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a non-septic shock model induced by zymosan in the rat
    • Cuzzocrea S, Zingarelli B, Caputi AP: Peroxynitrate-mediated DNA strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a non-septic shock model induced by zymosan in the rat. Shock 9:336-340, 1998.
    • (1998) Shock , vol.9 , pp. 336-340
    • Cuzzocrea, S.1    Zingarelli, B.2    Caputi, A.P.3
  • 28
    • 0030133352 scopus 로고    scopus 로고
    • Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
    • Darley-Usmar V, Halliwell B: Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmaceut Res 13:649, 1996.
    • (1996) Pharmaceut Res , vol.13 , pp. 649
    • Darley-Usmar, V.1    Halliwell, B.2
  • 29
    • 0021998590 scopus 로고
    • Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
    • Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167, 1985.
    • (1985) J Pharmacol Methods , vol.14 , pp. 157-167
    • Mullane, K.M.1    Kraemer, R.2    Smith, B.3
  • 30
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 31
    • 0019524365 scopus 로고
    • Multiple systems organ failure: The basal state
    • McMenamy RH, Birkhahn R, Oswald G, et al.: Multiple systems organ failure: the basal state. J Trauma 21:99-114, 1981.
    • (1981) J Trauma , vol.21 , pp. 99-114
    • McMenamy, R.H.1    Birkhahn, R.2    Oswald, G.3
  • 32
    • 0023232442 scopus 로고
    • Hypermetabolism, organ failure, and metabolic support
    • Cerra FB: Hypermetabolism, organ failure, and metabolic support. Surgery 101:1-14, 1987.
    • (1987) Surgery , vol.101 , pp. 1-14
    • Cerra, F.B.1
  • 33
    • 0024852805 scopus 로고
    • Neutrophil function and lipid peroxidation in a rat model of multiple organ failure
    • Van Bebber IPT, Boekholtz WKF, Goris R JA, et al.: Neutrophil function and lipid peroxidation in a rat model of multiple organ failure. J Surg Res 47:471, 1989.
    • (1989) J Surg Res , vol.47 , pp. 471
    • Van Bebber, I.P.T.1    Boekholtz, W.K.F.2    Goris, R.J.A.3
  • 34
    • 0028151406 scopus 로고
    • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: Formation of novel nitrogen-containing oxidized lipid derivatives
    • Rubbo H, Radi R, Trujillo M, et al.: Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269:26066-26075, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 26066-26075
    • Rubbo, H.1    Radi, R.2    Trujillo, M.3
  • 35
    • 0027162279 scopus 로고
    • Peroxynitrite modification of low density lipoprotein leads to recognition by the macrophage scavenger receptor
    • Graham A, Hogg N, Kalyanaraman B, et al.: Peroxynitrite modification of low density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett 330:18-25, 1993.
    • (1993) FEBS Lett , vol.330 , pp. 18-25
    • Graham, A.1    Hogg, N.2    Kalyanaraman, B.3
  • 36
    • 0001226142 scopus 로고
    • Nitric oxide in cells
    • Lancaster JR: Nitric oxide in cells. Am Sci 80:248-255, 1992.
    • (1992) Am Sci , vol.80 , pp. 248-255
    • Lancaster, J.R.1
  • 37
    • 0028507906 scopus 로고
    • Comparison between lung and liver peroxidation and mortality after zymosan peritonitis in the rats
    • Demling R, Nayak U, Ikegami K, et al.: Comparison between lung and liver peroxidation and mortality after zymosan peritonitis in the rats. Shock 2:222-227, 1994.
    • (1994) Shock , vol.2 , pp. 222-227
    • Demling, R.1    Nayak, U.2    Ikegami, K.3
  • 38
    • 0029366301 scopus 로고
    • The gut a cytokine-generating organ in systemic inflammation?
    • Mainous MR, Ertel W, Chaudry IH: The gut a cytokine-generating organ in systemic inflammation? Shock 4:193-199, 1995.
    • (1995) Shock , vol.4 , pp. 193-199
    • Mainous, M.R.1    Ertel, W.2    Chaudry, I.H.3
  • 39
    • 0031253810 scopus 로고    scopus 로고
    • Multiple organ failure following zymosan-induced peritonitis is mediated by nitric oxide
    • Cuzzocrea S, Zingarelli B, Sautebin L, et al.: Multiple organ failure following zymosan-induced peritonitis is mediated by nitric oxide. Shock 4:268-275, 1997.
    • (1997) Shock , vol.4 , pp. 268-275
    • Cuzzocrea, S.1    Zingarelli, B.2    Sautebin, L.3
  • 40
    • 0033072371 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat
    • Cuzzocrea S, Costantino G, Caputi AP: Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat. Shock 11:143-148, 1999.
    • (1999) Shock , vol.11 , pp. 143-148
    • Cuzzocrea, S.1    Costantino, G.2    Caputi, A.P.3
  • 41
    • 0031136492 scopus 로고    scopus 로고
    • Role of nitric oxide in a non-septic shock model induced by zymosan in the rat
    • Cuzzocrea S, Filippelli A, Zingarelli B, et al.: Role of nitric oxide in a non-septic shock model induced by zymosan in the rat. Shock 7:351-358, 1997.
    • (1997) Shock , vol.7 , pp. 351-358
    • Cuzzocrea, S.1    Filippelli, A.2    Zingarelli, B.3
  • 42
    • 0029065134 scopus 로고
    • The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat
    • Tracey WR, Nakane M, Kuk J, et al.: The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J Pharmacol Exp Ther 273:1295-1299, 1995.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1295-1299
    • Tracey, W.R.1    Nakane, M.2    Kuk, J.3
  • 43
    • 0029035476 scopus 로고
    • Altered immune responses in mice lacking inducible nitric oxide synthase
    • Wei XQ, Charles IG, Smith A, et al.: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411, 1995.
    • (1995) Nature , vol.375 , pp. 408-411
    • Wei, X.Q.1    Charles, I.G.2    Smith, A.3
  • 44
    • 0029763960 scopus 로고    scopus 로고
    • Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation
    • Salvemini D, Wang ZQ, Wyatt P, Bourdon DM, et al.: Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 118:829-838, 1996.
    • (1996) Br J Pharmacol , vol.118 , pp. 829-838
    • Salvemini, D.1    Wang, Z.Q.2    Wyatt, P.3    Bourdon, D.M.4
  • 45
    • 0031742316 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation
    • Ajuebor MN, Virag L, Flower RJ, et al.: Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology 95:625-630, 1998.
    • (1998) Immunology , vol.95 , pp. 625-630
    • Ajuebor, M.N.1    Virag, L.2    Flower, R.J.3
  • 46
    • 0032057735 scopus 로고    scopus 로고
    • Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthetase
    • Zingarelli B, Viràg L, Szabò A, et al.: Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthetase. Int J Mol Med 1:787-795, 1998.
    • (1998) Int J Mol Med , vol.1 , pp. 787-795
    • Zingarelli, B.1    Viràg, L.2    Szabò, A.3
  • 47
    • 0031975261 scopus 로고    scopus 로고
    • Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
    • Cuzzocrea S, Zingarelli B, Gilard E, et al.: Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Rad Biol Med 24:450-459, 1998.
    • (1998) Free Rad Biol Med , vol.24 , pp. 450-459
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilard, E.3
  • 48
    • 0029148018 scopus 로고
    • Peroxynitrite-mediated oxidation of dihydrorhoramine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury
    • Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhoramine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372:229-232, 1995.
    • (1995) FEBS Lett , vol.372 , pp. 229-232
    • Szabó, C.1    Salzman, A.L.2    Ischiropoulos, H.3
  • 49
    • 0028969011 scopus 로고
    • Evidence for in vivo peroxynitrite production in human acute lung injury
    • Kooy NW, Royall JA, Ye YZ, et al.: Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 151:1250-1254, 1995.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 1250-1254
    • Kooy, N.W.1    Royall, J.A.2    Ye, Y.Z.3
  • 50
    • 0029682870 scopus 로고    scopus 로고
    • Oxidative damage and tyrosine nitration from peroxynitrite
    • Beckman JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836-844, 1996.
    • (1996) Chem Res Toxicol , vol.9 , pp. 836-844
    • Beckman, J.S.1
  • 51
    • 0032556905 scopus 로고    scopus 로고
    • Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    • Eiserich JP, Hristova M, Cross CE, et al.: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391:393-397, 1998.
    • (1998) Nature , vol.391 , pp. 393-397
    • Eiserich, J.P.1    Hristova, M.2    Cross, C.E.3
  • 52
    • 0032584164 scopus 로고    scopus 로고
    • Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase
    • Szabó C, Viràg L, Cuzzocrea S, et al.: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase. Proc Natl Acad Sci USA 95:3867-3872, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3867-3872
    • Szabó, C.1    Viràg, L.2    Cuzzocrea, S.3
  • 53
    • 0030870278 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment
    • Szabó C, Lim LHK, Cuzzocrea S, et al.: Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J Exp Med 186:1041-1049, 1997.
    • (1997) J Exp Med , vol.186 , pp. 1041-1049
    • Szabó, C.1    Lim, L.H.K.2    Cuzzocrea, S.3
  • 54
    • 0032818362 scopus 로고    scopus 로고
    • Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat
    • Cuzzocrea S, Zingarelli B, Costantino G, et al.: Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat. Crit Care Med 27:1517-1523, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 1517-1523
    • Cuzzocrea, S.1    Zingarelli, B.2    Costantino, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.