Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: Modeling studies

Proteins: Structure, Function and Genetics

Volumn 44, Issue 1, 2001, Pages 32-43

  Miller, Maria ^a   Ginalski, Krzysztof ^a   Lesyng, Bogdan ^b   Nakaigawa, Noboru ^c   Schmidt, Laura ^a   Zbar, Berton ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF WARSAW   (Poland)

^c UNIVERSITY OF WARSAW   (Poland)

^d SAIC FREDERICK INC   (United States)

Author keywords

Homology modeling; MET proto oncogene; Oncogenic mutations; Receptor tyrosine kinase; Substrate specificity

Indexed keywords

MET KINASE; ONCOPROTEIN; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; KIDNEY CARCINOMA; MISSENSE MUTATION; MOLECULAR MODEL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; PROTO ONCOGENE;

CATALYTIC DOMAIN; ENZYME ACTIVATION; LIGANDS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; RECEPTORS, GROWTH FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS;

MUS MUSCULUS;

EID: 0035400394     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.1069     Document Type: Article

References (51)

1. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
2. Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
3. The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering
4. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
5. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
6. Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis
7. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
8. Germline mutation of RET codon 883 in two cases of de novo MEN 2B
9. C-kit mutations and mast cell disorders: A model of activating mutations of growth factor receptors
10. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
11. Novel mutations of the MET proto-oncogene in papillary renal carcinomas
12. Activating mutations for the met tyrosine kinase receptor in human cancer
13. Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
14. Different point mutations in the met oncogene elicit distinct biological properties
15. Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists
16. Domain movements in protein kinases
17. Crystal structure of the tyrosine kinase domain of the human insulin receptor
18. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
19. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
20. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
21. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
22. Assessment of comparative modeling in CASP2
23. Three-dimensional structure of the tyrosine kinase c-Src
24. The 2.35 A crystal structure of the inactivated form of chicken Src: A dynamic molecule with multiple regulatory interactions
25. Crystal structures of c-Src reveal features of its autoinhibitory mechanism
26. Crystal structure of the Src family tyrosine kinase Hck
27. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
28. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation
29. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequencing weighting, position-specific gap penalties and weight matrix choice
30. A new forcefield for molecular mechanical simulation of nucleic acids and proteins
31. Density-functional thermochemistry. III. The role of exact exchange
32. Errors in protein structures
33. Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: A new homology modeling tool
34. c-Abl kinase regulates the protein binding activity of c-Crk
35. Automated analysis of interatomic contacts in proteins
36. Molecular docking using surface complementarity
37. CASP2 molecular docking predictions with the LIGIN software
38. The mutationally activated Met receptor mediates motility and metastasis
39. Autoregulatory mechanisms in protein-tyrosine kinases
40. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
41. Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: Insights into kinase mechanism
42. Conformational changes in the activation loop of the insulin receptor's kinase domain
43. Switching signals on or off by receptor dimerization
44. Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src
45. Essential role of Gab1 for signaling by the c-Met receptor in vivo
46. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
47. Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor
48. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features