Myocardial preconditioning: Mechanisms and man

International Journal of Clinical Practice

Volumn 52, Issue 6, 1998, Pages 395-401

  Edwards, R J ^a   Marber, M S ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; GUANINE NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KINASE C;

ANGINA PECTORIS; AORTA CLAMPING; BALLOON; CELL DEATH; CORONARY ARTERY DILATATION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL DEATH; GTP-BINDING PROTEINS; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; POTASSIUM CHANNELS; PROTEIN KINASE C;

EID: 0031662202     PISSN: 13685031     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (103)

1. Office of Population Censuses and Surveys. Mortality statistics: cause. London: HMSO, 1991 (Series DH2, No 17).
2. McMurray J, Rankin A. Treatment of myocardial infarction, unstable angina, and angina pectoris. BMJ 1994; 309: 1343-1350.
3. Marber MS, Walker DM, Yellon DM. Ischaemic preconditioning. BMJ 1994; 308: 1-2.
4. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136.
5. Liu SG, Richards SC, Olsson RA et al. Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. Cardiovasc Res 1994; 28: 1057-1061.
6. Schott RJ, Rohmann S, Braun ER, Schaper W. Ischemic preconditioning reduces infarct size in swine myocardium. Circ Res 1990; 66: 1133-1142.
7. Li Y, Kloner RA. Ischemic preconditioning is not mediated by adenosine receptors in the rat heart (abstract). Circulation 1992; 86: 1-24.
8. Cohen MV, Downey JM. Ischemic preconditioning: can the protection be bottled? Lancet 1993; 341: 6.
9. Cohen MV, Downey JM. Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease. Ann Rev Med 1996; 47: 21-29.
10. Downey JM, Cohen MV. Signal transduction in ischaemic preconditioning. Adv Exp Med Biol 1997; 430: 39-55.
11. Van Winkle DM, Thornton J, Downey JM. Cardioprotection from ischemic preconditioning is lost following prolonged reperfusion in the rabbit. Cor Art Dis 1991; 2: 613-619.
12. Cohen MV, Yang XM, Downey JM. Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. Circ Res 1994; 74: 998-1004.
13. Ohgoshi Y, Goto Y, Futaki S et al. Increased oxygen cost of contractility in stunned myocardium of dog. Circ Res 1991; 69: 975-988.
14. Jenkins D, Pugsley W, Yellon D. Ischaemic preconditioning in a model of global ischaemia: infarct size limitation, but no reduction of stunning. J Mol Cell Cardiol 1995; 27: 1623-1632.
15. Walker DM, Marber MS, Walker JM, Yellon DM. Preconditioning in isolated supervised rabbit papillary muscles. Am J Physiol 1994; 266: H1534-H1540.
16. Cooper M, Yellon DM, Marber MS. A model of hypoxic preconditioning in adult rabbit cardiac myocytes in culture. In press.
17. Liu GS, Thornton J, Van Winkle DM et al. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 1991; 84: 350-356.
18. Wall TM, Sheehy R, Hartman JC. Role of bradykinin in myocardial preconditioning. J Pharmacol Exp Ther 1994; 270: 681-689.
19. Bankwala Z, Hale SL, Kloner RA. Alpha-adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning. Circulation 1994; 90: 1023-1028.
20. Bains CP, Goto M, Downey JM. Oxygen free radicals released during ischaemic preconditioning contribute to cardioprotection. J Mol Cell Cardiol 1997; 29(3): 991-999.
21. Noda K, Sasaguri M, Idesishi M et al. Role of locally formed angiotensin II and bradykinin in the reduction of myocardial infarct size in dogs. Cardiovasc Res 1995; 27: 334-340.
22. Vegh A, Papp JG, Szekeres L, Parratt JR. Prevention by an inhibitor of the L arginine-nitric oxide pathway of the antiarrhythmic effects of bradykinin in anaesthetised dogs. Br J Pharmacol 1993; 110: 18-19.
23. Schults JJ, Hsu AK, Garrett GJ. Ischaemic preconditioning is mediated by a peripheral opioid receptor mechanism in the intact rat heart. J Mol Cell Cardiol 1997; 29: 1355-1362.
24. Van Wylen D, Willis J, Shodi J et al. Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow. Am J Physiol 1990; 258: H1642-H1649.
25. Goto M, Yongge L, Xi-Ming Y et al. Role of bradykinin in protection of ischaemic preconditioning in rabbit hearts. Circ Res 1995; 77: 611-621.
26. Thornton JD, Thornton CS, Downey JM, Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation. Am J Physiol 1993; 265: H504-H508.
27. Sugden PH, Bogoyevitch MA. Intracellular signalling through protein kinases in the heart. Cardiovasc Res 1995; 30: 478-492.
28. Thornton J, Liu G, Downey J. Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G protein mechanism. J Mol Cell Cardiol 1993; 25: 311-320.
29. Lawson C, Coltart D, Hearse D. The antiarrhythmic action of ischaemic preconditioning in rat hearts does not involve functional Gi proteins. Cardiovasc Res 1993; 27: 681-687.
30. Cohen MV, Liu Y, Liu GS et al. Phospholipase D plays a role in ischemic preconditioning in rabbit heart. Circulation 1996; 94: 1713-1718.
31. Newton AC. Protein kinase C: structure, function and regulation. J Biol Chem 1995; 270: 28495-28498.
32. Brooks G, Hearse DJ. Role of protein kinase C in ischemic preconditioning: player or spectator? Circ Res 1996; 79: 627-630.
33. Speechly-Dick ME, Mocanu MM, Yellon DM. Protein kinase C: its role in ischemic preconditioning in the rat. Circ Res 1994; 75: 586-590.
34. Mitchell MB, Meng X, Ao L et al. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 1995; 76: 73-81.
35. Ytrehus K, Liu Y, Downey J. Preconditioning protects ischaemic rabbit heart by protein kinase C activation. Am J Physiol 1994; 226: H1145-H1152.
36. Vahlhaus C, Schulz R, Post H et al. No prevention of ischemic preconditioning by the protein kinase C inhibitor staurosporine in swine. Circ Res 1996; 79: 407-414.
37. Genot EM, Parker PJ, Cantrell DA. Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation. J Biol Chem 1995; 270: 9833-9839.
38. Decock JBJ, Gillespie-Brown J, Parker PJ et al. Classical, novel and atypical isoforms of PKC stimulate ANF- and TRE/AP-1-regulated-promoter activity in ventricular cardiomyocytes. Febs Letts 1994; 356: 275-278.
39. Zhao J, Renner O, Wrightman L et al. The expression of constituitively active isotypes of protein kinase C to investigate preconditioning. J Biol Chem 1998 (in press).
40. Ping P, Zhang J, Qiu Y et al. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res 1997; 81: 404-414.
41. Mitchel M, Meng X, Ao L et al. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 1995; 76: 73-81.
42. Tsuchida A, Thompson R, Olsson RA, Downey JM. The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in the rabbit heart. J Mol Cell Cardiol 1994; 26: 303-311.
43. Hashimi W, Thornton JD, Downey JM, Cohen MV. Chronic adenosine A1 agonist exposure results in adenosine receptor rather than G protein downregulation (abstract). Circulation 1994; 90: 1-107.
44. Sumeray MS, Yellon DM. Myocardial preconditioning: what have we learned. Eur Heart J 1997; 18(suppl A): A8-A14.
45. Findlay I. The ATP-sensitive potassium channel of cardiac muscle and action potential shortening during metabolic stress. Cardiovasc Res 1994; 15: 19-25.
46. Cole WC, McPherson CD, Sonlag D. ATP-regulated K+ channels protect the myocardium against ischaemic/reperfusion damage. Circ Res 1991; 69: 571-581.
47. Gross GJ, Selph PG, Dzwonczyk S. Role of myocardial ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223-233.
48. Light PE, Sabir AA, Allen BG et al. Protein kinase C-induced changes in the stoichiometry of ATP binding activate cardiac ATP-sensitive K+ channels. A possible mechanistic link to preconditioning. Circ Res 1996; 79: 399-406.
49. Liu Y, Downey JM. Ischemic preconditioning protects against infarction in rat heart. Am J Physiol 1992; 263: H1107-H1112.
50. Liu Y, Gao WD, O'Rourke B, Marban E. Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine: implication for ischemic preconditioning. Circ Res 1996; 78: 443-454.
51. Welch JW. How cells respond to stress. Sci Am 1993; 268: 34-41.
52. Karmazyn M, Mailer K, Currie RW. Acquisition and decay of heat shock enhanced post-ischemic ventricular recovery. Am J Physiol 1991; 259: H424-H431.
53. Marber MS, Latchman DS, Walker MJ, Yellon DM. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 1993; 88: 1264-1272.
54. Kuzuya T, Hoshida S, Yamashita N, Fuji H et al. Delayed effects of sublethal laischemia on the acquisition of tolerance to ischemia. Circ Res 1993; 72: 1293-1299.
55. Sun JZ, Tang XL, Park SW et al. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. J Clin Invest 1996; 97: 562-576.
56. Marber MS, Walker J, Latchman D, Yellon D. Myocardial protection after whole body heat stress in the rabbit is dependant on metabolic substrate and is related to the amount of the inducible 70-kDa heat stress protein. J Clin Invest 1994; 93: 1087-1094.
57. Cumming DVE, Heads RJ, Watson A et at. Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins. J Mol Cell Cardiol 1996; 28: 2343-2349.
58. Marber M, Mestril R, Chi S-H et al. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 1995; 95: 1446-1456.
59. Hoshida S, Kuzuya T, Fuji H et al. Sublethal ischemia alters myocardial antioxidant activity in the canine heart. Am J Physiol 1993; 264: H33-H39.
60. Currie R, Tanguay R, Kingma J. Heat shock response and limitation of tissue necrosis during occlusion-reperfusion in rabbit hearts. Circulation 1993; 87: 963-971.
61. Bolli R, Zughaib M, Li XY et al. Demonstration of free radical generation in stunned myocardium of intact dogs with the use of spin trap alpha-phenyl N-tert butyl nitrone. J Clin Invest 1995; 96: 1066-1084.
62. Kingma JG, Simard D, Rouleau JR et al. Effect of 3-aminotriazole on hyperthermia-mediated cardioprotection in rabbits. Am J Physiol 1996; 70: 1165-1171.
63. Baxter GF, Marber MS, Patel VC, Yellon DM. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. Circulation 1994; 90: 2993-3000.
64. Baxter GF, Goma FM, Yellon DM. Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium. Br J Pharmacol 1995; 115: 22-24.
65. Meller ST, Gebhart GF. A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience 1992; 48: 501-524.
66. Crea F, Gaspardone A, Kaski JC et al. Relation between stimulation site of cardiac afferent nerves by adenosine and distribution of cardiac pain: results of a study in patients with stable angina. J Am Coll Cardiol 1992; 20: 1498-1502.
67. Gaspardone A, Crea F, Tomai F, Versaci F et al. Muscular and cardiac adenosine-induced pain is mediated by Al receptors. J Am Coll Cardiol 1995; 25: 251-257.
68. Iwasaka T, Nakamura S, Karakawa M et al. Cardioprotective effect of unstable angina to acute anterior myocardial infarction. Chest 1994; 105: 57-61.
69. Anzai T, Yoshikawa T, Asakura Y et al. Effect on short-term prognosis and left ventricular function of angina pectoris prior to first Q-wave anterior wall acute myocardial infarction. Am J Cardiol 1994; 74: 755-759.
70. Ottani F, Galvani M, Ferrini D et al. Prodromal angina limits infarct size. A role for ischemic preconditioning. Circulation 1995; 91: 291-297.
71. Kloner RA, Shook T, Pryzklenk K et al. Previous angina alters in-hospital outcome in TIMI-4: a clinical correlate to preconditioning? Circulation 1995; 91: 37-47.
72. Nakagawa Y, Ito H, Kitakaze M, Kusuoka H et al. Effect of angina pectoris on myocardial protection in patients with reperfused anterior wall myocardial infarction: retrospective clinical evidence of preconditioning. J Am Coll Cardiol 1995; 25: 1076-1083.
73. Anzai T, Yoshikawa T, Asakura Y et al. Preinfarction angina as a major predictor of left ventricular function and long-term prognosis after a first Q wave myocardial infarction. J Am Coll Cardiol 1995; 26: 319-327.
74. Andreotti F, Pasceri V, Hackett DR et al. Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N Engl J Med 1996; 334: 7-12.
75. Ishihara M, Hikaru S, Tateishi H et al. Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long term prognosis. J Am Coll Cardiol 1997; 30: 970-975.
76. Rytter L, Troelsen S, Beck-Nielson H. Prevalence and mortality of acute myocardial infarction in patients with diabetes. Diab Care 1985; 8: 230-234.
77. Tomai F, Crea F, Gaspardone A et al. Mechanisms of cardiac induced pain during coronary angioplasty. J Am Coll Cardiol 1993; 22: 1892-1896.
78. Deutsch E, Berger M, Kussmaul WG et al. Adaptation to ischemia during percutaneous transluminal coronary angioplasty: clinical hemodynamic and metabolic features. Circulation 1990; 82: 2044-2051.
79. Cribier A, Korsatz L, Koning R et al. Improved myocardial response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: a prospective study. J Am Coll Cardiol 1992; 20: 578-586.
80. Tomai F, Crea F, Gaspardone A et al. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. Circulation 1994; 90: 700-705.
81. Kerensky RA, Kutcher MA, Braden GA et al. The effects of intracoronary adenosine on preconditioning during coronary angioplasty. Clin Cardiol 1995; 18: 91-96.
82. Dupouy P, Geschwind H, Pelle G et al. Repeated coronary artery occlusions during routine balloon angioplasty do not induce myocardial preconditioning in humans. J Am Coll Cardiol 1996; 27: 1374-1380.
83. Claeys MJ, Vrints CJ, Bosmans JM et al. Aminophylline inhibits adaptalion to ischaemia during angioplasty. Eur Heart J 1996; 17: 539-544.
84. Kerensky RA, Kutcher MA, Braden GA et al. The effect of intracoronary adenosine on preconditioning during coronary angioplasty. J Am Coll Cardiol 1994; 23: 869-878.
85. De Jong JW, Cargnoni A, Huizer T et al. Lactate and hypoxanthine release after coronary angioplasty: no evidence of preconditioning (abstract). J Mol Cell Cardiol 1993; 25(suppl 1): S37.
86. Sakata Y, Kodama K, Kitakaze M et al. Different mechanisms of ischemic adaptation to repeated coronary occlusion in patients with and without recruitable collateral circulation. J Am Coll Cardiol 1997; 30: 1679-1686.
87. Leesar M, Stoddard M, Mirza A et al. Preconditioning of human myocardium with adenosine during coronary angioplasty. Circulation 1997; 95: 2500-2507.
88. Marber MS, Joy MD, Yellon DM. Warm-up in angina: is it ischaemic preconditioning? Br Heart J 1994; 72: 213-215.
89. Wayne EJ, Graybiel A. Observations on the effect of food, gastric distension, external temperature, and repeated exercise on angina of effort, with a note on angina sine dolore. Clin Sci 1934; 1: 287-304.
90. Wayne EJ, Laplace LB. Observations on angina of effort. Clin Sci 1933; 1: 103-129.
91. MacAlpin RN, Kattus AA. Adaptation to exercise in angina pectoris. Circulation 1966; 33: 183-201.
92. Williams DO, Bass TA, Gewirtz H, Most AS. Adaptation to the stress of tachycardia in patients with coronary artery disease: insight into the mechanism of the warm-up phenomenon. Circulation 1985; 71: 687-692.
93. Okazaki Y, Kodama K, Sato H et al. Attenuation of increased regional myocardial oxygen consumption during exercise as a major cause of warm-up phenomenon. J Am Coll Cardiol 1993; 21: 1597-1604.
94. Maybaum S, Ilan M, Mogilevsky J, Tzivoni D. Improvement in ischemic parameters during repeated exercise testing: a possible model for myocardial preconditioning. Am J Cardiol 1996; 78: 1087-1091.
95. Tomai F, Crea F. Danesi A et al. Mechanisms of the warm-up phenomenon. Eur Heart J 1996; 17: 1022-1027.
96. Yellon DM, Alkhulaifi AM, Pugsley WB. Preconditioning the human myocardium. Lancet 1993; 342: 276-277.
97. Alkhulaifi AM. Preconditioning the human heart. Ann R Coll Surg Engl 1997; 79: 49-54.
98. Jenkins DP, Pugsley WB, Alkhulaifi AM et al. Ischemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery. Heart 1997; 77: 314-318.
99. Cleveland JC, Meldrum DR, Rowland RT et al. Preconditioning and hypothermic cardioplegia protect human heart equally against ischaemia. Ann Thorac Surg 1997; 63: 147-152.
100. Lee HT, Lafaro RJ, Reed GE. Pretreatment of human myocardium with adenosine during open heart surgery. J Card Surg 1995; 10: 665-676.
101. Speechley-Dick ME, Grover GJ, Yellon DM. Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependant K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model. Circ Res 1995; 77: 1030-1035.
102. Morris SD, Yellon DM. Angiotensin converting enzyme inhibitors potentiate preconditioning through bradykinin B2 receptor activation in human heart. J Am Coll Cardiol 1997; 29: 1599-1606.
103. Ikonomidis JS, Tumiati LC, Weisel RD et al. Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischemia. Cardiovasc Res 1994; 28: 1285-1291.