-
1
-
-
0034660559
-
Searching for genetic determinants in the new millennium
-
The author summarizes the historical difficulties of the linkage approach for common diseases, and suggests both reasons for the difficulties and alternative approaches
-
Risch N. Searching for genetic determinants in the new millennium. Nature. 405:2000;847-856. The author summarizes the historical difficulties of the linkage approach for common diseases, and suggests both reasons for the difficulties and alternative approaches.
-
(2000)
Nature
, vol.405
, pp. 847-856
-
-
Risch, N.1
-
2
-
-
0028877463
-
Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
-
Lander E., Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 11:1995;241-247.
-
(1995)
Nat Genet
, vol.11
, pp. 241-247
-
-
Lander, E.1
Kruglyak, L.2
-
3
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
4
-
-
0033624575
-
The common PPAR-γ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
This is a recent example of a large case-control study of a candidate gene for non-insulin-dependent diabetes mellitus where the authors demonstrate statistically significant association of the disease to a very common SNP of small effect
-
Altshuler D., Hirschhorn J.N., Klannemark M., Lindgren C.M., Vohl M.C., Nemesh J., Lane C.R., Schaffner S.F., Bolk S., Brewer C., Tuomi T., et al. The common PPAR-γ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 26:2000;76-80. This is a recent example of a large case-control study of a candidate gene for non-insulin-dependent diabetes mellitus where the authors demonstrate statistically significant association of the disease to a very common SNP of small effect.
-
(2000)
Nat Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.C.5
Nemesh, J.6
Lane, C.R.7
Schaffner, S.F.8
Bolk, S.9
Brewer, C.10
Tuomi, T.11
-
5
-
-
0023894935
-
The affected-pedigree-member method of linkage analysis
-
Weeks D.E., Lange K. The affected-pedigree-member method of linkage analysis. Am J Hum Genet. 42:1988;315-326.
-
(1988)
Am J Hum Genet
, vol.42
, pp. 315-326
-
-
Weeks, D.E.1
Lange, K.2
-
6
-
-
0028301661
-
A class of tests for linkage using affected pedigree members
-
Whittemore A.S., Halpern J. A class of tests for linkage using affected pedigree members. Biometrics. 50:1994;118-127.
-
(1994)
Biometrics
, vol.50
, pp. 118-127
-
-
Whittemore, A.S.1
Halpern, J.2
-
7
-
-
0029886532
-
Parametric and nonparametric linkage analysis: A unified multipoint approach
-
Kruglyak L., Daly M.J., Reeve-Daly M.P., Lander E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. AmJ Hum Genet. 1179:1996;1347-1363.
-
(1996)
AmJ Hum Genet
, vol.1179
, pp. 1347-1363
-
-
Kruglyak, L.1
Daly, M.J.2
Reeve-Daly, M.P.3
Lander, E.S.4
-
8
-
-
0030728925
-
Allele-sharing models: LOD scores and accurate linkage tests
-
Kong A., Cox N.J. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet. 61:1997;1179-1188.
-
(1997)
Am J Hum Genet
, vol.61
, pp. 1179-1188
-
-
Kong, A.1
Cox, N.J.2
-
9
-
-
0034660560
-
Pharmacogenomics and the practice of medicine
-
The author provides a comprehensive review of the proposed use of SNPs in case-control studies of pharmacogenomic traits, and looks at the future of SNP profiling in predicting drug response
-
Roses A.D. Pharmacogenomics and the practice of medicine. Nature. 405:2000;857-866. The author provides a comprehensive review of the proposed use of SNPs in case-control studies of pharmacogenomic traits, and looks at the future of SNP profiling in predicting drug response.
-
(2000)
Nature
, vol.405
, pp. 857-866
-
-
Roses, A.D.1
-
10
-
-
0030688004
-
Variations on a theme: Cataloging human DNA sequence variation
-
Collins F.S., Guyer M.S., Chakravarti A. Variations on a theme: cataloging human DNA sequence variation. Science. 278:1997;1580-1581.
-
(1997)
Science
, vol.278
, pp. 1580-1581
-
-
Collins, F.S.1
Guyer, M.S.2
Chakravarti, A.3
-
11
-
-
0033039497
-
Prospects for whole-genome linkage disequilibrium mapping of common disease genes
-
The author carries out systematic simulations to predict the power of case-control genetic studies that use SNPs and assume a variety of models of common disease. He also relates the power of this approach to number of SNP markers used in the genome-wide scan and predicts that more isolated populations may not have an advantage for such approaches
-
Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 22:1999;139-144. The author carries out systematic simulations to predict the power of case-control genetic studies that use SNPs and assume a variety of models of common disease. He also relates the power of this approach to number of SNP markers used in the genome-wide scan and predicts that more isolated populations may not have an advantage for such approaches.
-
(1999)
Nat Genet
, vol.22
, pp. 139-144
-
-
Kruglyak, L.1
-
12
-
-
0345350737
-
Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: Studies of the HLA class II loci
-
Arheim N., Strange C., Erlich H. Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc Natl Acad Sci USA. 82:1985;6970-6974.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 6970-6974
-
-
Arheim, N.1
Strange, C.2
Erlich, H.3
-
13
-
-
0031588662
-
Genetic analysis of complex diseases
-
Muller-Myhsok B., Abel L. Genetic analysis of complex diseases. Science. 275:1997;1328-1329.
-
(1997)
Science
, vol.275
, pp. 1328-1329
-
-
Muller-Myhsok, B.1
Abel, L.2
-
14
-
-
0033073397
-
Power of association and linkage tests when the disease alleles are unobserved
-
Tu I.P., Whittemore A.S. Power of association and linkage tests when the disease alleles are unobserved. Am J Hum Genet. 64:1999;641-649.
-
(1999)
Am J Hum Genet
, vol.64
, pp. 641-649
-
-
Tu, I.P.1
Whittemore, A.S.2
-
15
-
-
0027377799
-
Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
-
Spielman R.S., McGinnis R.E., Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 52:1993;506-516.
-
(1993)
Am J Hum Genet
, vol.52
, pp. 506-516
-
-
Spielman, R.S.1
McGinnis, R.E.2
Ewens, W.J.3
-
16
-
-
0025008677
-
Linkage strategies for genetically complex traits. II. The power of affected relative pairs
-
Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet. 46:1990;229-241.
-
(1990)
Am J Hum Genet
, vol.46
, pp. 229-241
-
-
Risch, N.1
-
17
-
-
0031672085
-
Population genomics: Laying the groundwork for genetic disease modeling and targeting
-
Gulcher J.R., Stefansson K. Population genomics: laying the groundwork for genetic disease modeling and targeting. Clin Chem Lab Med. 36:1998;523-527.
-
(1998)
Clin Chem Lab Med
, vol.36
, pp. 523-527
-
-
Gulcher, J.R.1
Stefansson, K.2
-
18
-
-
0033941403
-
MtDNA and the origin of the Icelanders: Deciphering signals of recent population history
-
Helgason A., Sigurethardottir S., Gulcher J.R., Ward R., Stefansson K. mtDNA and the origin of the Icelanders: deciphering signals of recent population history. Am J Hum Genet. 66:2000;999-1016.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 999-1016
-
-
Helgason, A.1
Sigurethardottir, S.2
Gulcher, J.R.3
Ward, R.4
Stefansson, K.5
-
19
-
-
0346455087
-
The mutation rate in the human mtDNA control region
-
Sigurgardottir S., Helgason A., Gulcher J.R., Stefansson K., Donnelly P. The mutation rate in the human mtDNA control region. Am J Hum Genet. 66:2000;1599-1609.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 1599-1609
-
-
Sigurgardottir, S.1
Helgason, A.2
Gulcher, J.R.3
Stefansson, K.4
Donnelly, P.5
-
20
-
-
84994838237
-
-
World Health Organization
-
World Health Organization http://www.who.org.
-
-
-
-
21
-
-
84994878957
-
-
Protection of privacy at deCODE genetics
-
Protection of privacy at deCODE genetics http://www.decode.is/ppt/protection/index.htm.
-
-
-
-
23
-
-
0034098774
-
Allegro, a new computer program for multipoint linkage analysis
-
The authors describe the Allegro program and how to obtain this program free for non-commercial use
-
Gudbjartsson D.F., Jonasson K., Frigge M.L., Kong A. Allegro, a new computer program for multipoint linkage analysis. Nat Genet. 25:2000;12-13. The authors describe the Allegro program and how to obtain this program free for non-commercial use.
-
(2000)
Nat Genet
, vol.25
, pp. 12-13
-
-
Gudbjartsson, D.F.1
Jonasson, K.2
Frigge, M.L.3
Kong, A.4
-
24
-
-
0003408940
-
-
Baltimore and London: The Johns Hopkins University Press
-
Ott J. Analysis of Human Linkage. edn 3:1999;The Johns Hopkins University Press, Baltimore and London.
-
(1999)
Analysis of Human Linkage Edn 3
-
-
Ott, J.1
-
25
-
-
0033608187
-
Parkinson disease in twins: An etiologic study
-
Tanner C.M., Ottman R., Goldman S.M., Ellenberg J., Chan P., Mayeux R., Langston J.W. Parkinson disease in twins: an etiologic study. J Am Med Assoc. 281:1999;341-346.
-
(1999)
J Am Med Assoc
, vol.281
, pp. 341-346
-
-
Tanner, C.M.1
Ottman, R.2
Goldman, S.M.3
Ellenberg, J.4
Chan, P.5
Mayeux, R.6
Langston, J.W.7
-
26
-
-
0034649710
-
Familial aggregation of Parkinson's disease in Iceland
-
Sveinbjornsdottir S., Hicks A.A., Jonsson T., Petursson H., Guomundsson G., Frigge M.L., Kong A., Gulcher J.R., Stefansson K. Familial aggregation of Parkinson's disease in Iceland. N Engl J Med. 343:2000;1765-1770.
-
(2000)
N Engl J Med
, vol.343
, pp. 1765-1770
-
-
Sveinbjornsdottir, S.1
Hicks, A.A.2
Jonsson, T.3
Petursson, H.4
Guomundsson, G.5
Frigge, M.L.6
Kong, A.7
Gulcher, J.R.8
Stefansson, K.9
|