Structure and function of the small ribozymes

Current Opinion in Structural Biology

Volumn 11, Issue 3, 2001, Pages 315-320

  Butcher, S E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAIRPIN RIBOZYME; HAMMERHEAD RIBOZYME; HEPATITIS DELTA VIRUS RIBOZYME; NEUROSPORA VS RIBOZYME; NUCLEOTIDE; RIBOZYME; UNCLASSIFIED DRUG;

BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; GENE FUNCTION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEIC ACID STRUCTURE; PKA; PRIORITY JOURNAL; REVIEW; RNA STRUCTURE;

DELTA VIRUS; HEPATITIS DELTA VIRUS; NEUROSPORA;

EID: 0035367070     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00207-4     Document Type: Review

References (46)

1. Crystallographic structures of the hammerhead ribozyme: Relationship to ribozyme folding and catalysis
2. 2+ binding affinities to the hammerhead ribozyme and correlation with cleavage activity
3. 31P NMR and phosphorothioate substitutions
4. 2+-nitrogen interactions in RNA probed by electron spin-echo envelope modulation spectroscopy: Application to the hammerhead ribozyme
5. 2+ sites in the hammerhead ribozyme investigated by EPR and continuous-wave Q-band ENDOR spectroscopies
6. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate
7. A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme
8. Probing the binding of Tb(III) and Eu(III) to the hammerhead ribozyme using luminescence spectroscopy
9. A re-investigation of the thio effect at the hammerhead cleavage site
10. Cobalt hexammine inhibition of the hammerhead ribozyme
11. Activities and relative affinities of divalent metals in unmodified and phosphorothioate-substituted hammerhead ribozymes
12. Multiple conformational states of the hammerhead ribozyme, broad time range of relaxation and topology of dynamics
13. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
14. Does a single metal ion bridge the A-9 and scissile phosphates in the catalytically active hammerhead ribozyme structure?
15. The mechanism of phosphodiester hydrolysis: Near in-line attack conformations in the hammerhead ribozyme
16. a of the 2′-hydroxyl group of a phosphorylated ribose: Implications for the mechanism of hammerhead ribozyme catalysis
17. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
18. Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology
19. Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme
20. Crystal structure of a hepatitis delta virus ribozyme
21. Crystallization and structure determination of a hepatitis delta virus ribozyme: Use of the RNA-binding protein U1A as a crystallization module
22. A role for upstream RNA structure in facilitating the catalytic fold of the genomic hepatitis delta virus ribozyme
23. The kinetics and magnesium requirements for the folding of antigenomic delta ribozymes
24. A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes
25. Kinetic scheme for intermolecular RNA cleavage by a ribozyme-derived from hepatitis delta virus RNA
26. Structure and function of the hairpin ribozyme
27. Solution structure of loop A from the hairpin ribozyme from tobacco ringspot virus satellite
28. Solution structure of the loop B domain from the hairpin ribozyme
29. Nucleotide analog interference mapping of the hairpin ribozyme: Implications for secondary and tertiary structure formation
30. Determination of metal binding sites within the hairpin ribozyme domains by NMR
31. Probing non-selective cation binding in the hairpin ribozyme with Tb(III)
32. Structural basis for the guanosine requirement of the hairpin ribozyme
33. Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2′-modified nucleosides
34. Analysis of the functional role of a G-A sheared base pair by in vitro genetics
35. Folding of the four-way junction of the hairpin ribozyme
36. Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction
37. Tertiary structure stabilization promotes hairpin ribozyme ligation
38. The folding of the hairpin ribozyme dependence of the loops and the junction
39. Helical junctions as determinants for RNA folding: Origin of tertiary structure stability of the hairpin ribozyme
40. Adenine protonation in domain B of the hairpin ribozyme
41. Structure of the ribozyme substrate hairpin of Neurospora VS RNA: A close look at the cleavage site
42. Rearrangement of a stable RNA secondary structure during VS ribozyme catalysis
43. RNA folding causes secondary structure rearrangement
44. Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis
45. A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme
46. A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA