Aberrant Expression of Cyclin D1 in Pulmonary Proliferative Lesions Induced by High Doses of Urethane in Transgenic Mice Carrying the Human Prototype c-H-ras Gene

Journal of Veterinary Medical Science

Volumn 63, Issue 3, 2001, Pages 261-268

  Mori, Ikuo ^a   Yasuhara, Kazuo ^b   Hayashi, Shim Mo ^a   Nonoyama, Takashi ^a   Nomura, Tatsuji ^d   Yanai, Tokuma ^c   Masegi, Toshiaki ^c   Mitsumori, Kunitoshi ^b  

^a Drug Anal Pharmacokin Res Labs   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d NONE   (Japan)

Author keywords

Alveolar bronchiolar tumor; Cyclin D1; Immunohistochemistry; rasH2 mouse; Urethane

Indexed keywords

MUS MUSCULUS;

CARCINOGEN; CYCLINE; PROTEIN P53; URETHAN;

ADENOMA; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS; LUNG ALVEOLUS CELL CARCINOMA; LUNG TUMOR; MALE; METABOLISM; MOUSE; ONCOGENE RAS; PATHOLOGY; TRANSGENIC MOUSE;

ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; ADENOMA; ANIMALS; CARCINOGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROLIFERATING CELL NUCLEAR ANTIGEN; PULMONARY ALVEOLI; TUMOR SUPPRESSOR PROTEIN P53; URETHANE;

EID: 0035290353     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.63.261     Document Type: Article

References (39)

1. Arber, N., Hibshoosh H., Moss, S. F., Sutter, T., Zhang, Y., Begg, M., Wang, S., Weinstein, I. B. and Holt, P. R. 1996. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 110: 669-674.
2. Buckley, M. F., Sweeney, K. J., Hamilton J. A., Sini R. L., Manning, D. L., Nicholson R. I., deFazio, A., Watts, C.K., Musgrove, E. A. and Sutherland R. L. 1993. Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127-2133.
3. Cazorla, M., Hernandez, L., Fernandez, P. L., Fabra. A, Peinado, M. A., Dasenbrock, C., Tillmann, T., Kamino, K., Campo, E., Kohler, M., Morawieltz, G., Cardesa, A., Tomatis, L. and Mohr, U. 1998. Ki-ras gene mutations and absence of p53 gene mutations in spontaneous and urethane-induced early lung lesions in CBA/J mice. Mol. Carcinog. 21: 251-260.
4. Dahl, G. A., Miller, J. A. and Miller, E. C. 1978. Vinyl carbarnate as a promutagen and a more carcinogenic analog of ethyl carbamate. Cancer Res. 38: 3793-3804.
5. Doi, S-T., Kimura, M. and Katsuki, M. 1994. Site-specific mutation of the Human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice. Jpn. J. Cancer Res. 85: 801-807.
6. Donnellan, R. and Chetty, R. 1998. Cyclin Dl and human neoplasia. Mol Pathol. 51: 1-7.
7. el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. and Vogelstein, B. 1993. WAFI, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
8. Hayashi, S., Mitsumori, K., Yasuhara, K., Mori, I., Imazawa, T., Onodera, H., Nonoyama, T., Takahashi, M. and Hayashi, Y. 1997. Significance of cyclin D1 overexpression and K-ras point mutations in lung tumors induced by N-methyl-N-nitrosourthane in hamsters. J. Toxicol. Pathol. 10: 137-143.
9. Hunter, T. and Pines, J. 1994. Cyclins and cancer II: cyclin D and cdk inhibitors come of age. Cell 79: 573-582.
10. Jacks, T. and Weinberg, R. A. 1996. Cell-cycle control and its watchman. Nature (Lond.) 381: 643-644.
11. Jiang, W., Kahn, S. M., Zhou, P., Zhang, Y. J., Cacace, A. M., Infante, A. S., Doi, S., Santella, R. M. and Weinstein, I. B. 1993. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8: 3447-3457.
12. Kurasono, Y., Ito, T., Kameda, Y., Nakamura, N and Kitamura, H. 1998. Expression of cyclin D1, retinoblastoma gene protein, and p16 MTS1 protein in atypical adenomatous hyperplasia and adenocarcinoma of the lung. An immunohistochemical analysis. Virchows Arch. 432: 207-215.
13. 6-Ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxidc metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate. Carcinogenesis 11: 463-473.
14. Lukas, J., Pagano, M., Staskova, Z., Draetta G. and Bartek, J. 1994. CyclinD1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9: 707-718.
15. Maestro, R., Dolcetti, R., Gasparotto, D., Doglioni, C., Pelucchi, S., Barzan, L., Grandi, E. and Boiocchi, M. 1992. High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene 7: 1159-1166.
16. Malkinson, A. M. 1998. Molecular comparison of human and mouse pulmonary adenocarcinomas. Exp. Lung Res. 24: 541-555.
17. Michalides, R., van Veelen, N., Hart, A., Loftus, B., Wientjens, E. and Balm, A. 1995. Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res. 55: 975-978.
18. Mirvish, S. S. 1968. The carcinogenic action and metabolism of urethan and N-hydroxyurethan. Adv. Cancer Res. 11: 1-42.
19. Mitsumori, K., Wakana, S., Yamamoto, S., Kodama, Y., Yasuhara, K., Nomura, T., Hayashi, Y. and Maronpot, R. R. 1997. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. Mol. Carcinog. 20: 298-307.
20. Mitsumori, K., Yasuhara, K., Mori, I., Hayashi, S., Shimo, T., Onodera, H., Nomura, T. and Hayashi, Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett. 129: 181-190.
21. Mori, I., Yasuhara, K., Hayashi, S., Nonoyama T., Nomura T. and Mitsumori, K. 2000. Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett. 153: 199-209.
22. Nurse, P. 1994. Ordering S phase and M phase in the cell cycle. Cell 79: 547-550.
23. Ogawa, K., Imaida, K., Matsui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N. and Shirai, T. 1996. Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis 17: 341-345.
24. Park, K. K., Liem, A., Stewart, B. C. and Miller, J. A. 1993. Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane). Carcinogenesis 14: 441-450.
25. Robles, A. I. and Conti C. J. 1995. Early overexpression of cyclin D1 protein in mouse skin carcinogenesis Carcinogenesis 16: 781-786.
26. Romach, E. H., Goldsworthy, T. L., Maronpot, R. R. and Fox, T.R. 1997. Altered gene expression in spontaneous hepatocellular carcinomas from male B6C3F1 mice. Mol. Carcinog. 19: 31-38.
27. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S. and Katsuki, M. 1990. Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5: 1195-1200.
28. Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79: 551-555.
29. Svensson, K. 1998. Alkylation of protein and DNA in mice treated with urethane. Carcinogenesis 9: 2197-2201.
30. Tam, A. S., Foley, J. F., Devereux, T. R., Maronpot, R. R. and Massey, T.E. 1999. High frequency and heterogeneous distribution of p 53 mutations in aflatoxin B1-induced mouse lung tumors. Cancer Res. 59: 3634-3640.
31. Yamamoto, S., Mitsumori, K., Kodama, Y., Matsunuma, N., Manabe, S., Okamiya, H., Suzuku, H., Fukuda, T., Sakamaki, Y., Sunaga, M., Nomura, G., Hioki, K., Wakana, S., Nomura, T. and Hayashi, Y. 1996. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17: 2455-2461.
32. Yamamoto, S., Hayashi, Y., Mitsumori, K. and Nomura, T. 1997. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene. Lab. Anim. Sci. 47: 121-126.
33. Yamamoto, S., Urano, K., Koizumi, H., Wakana, S., Hioki, K., Mitsumori, K., Kurokawa, Y., Hayashi, Y. and Nomura, T. 1998. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ. Health Perspect. 106 (Suppl. 1): 57-69.
34. Yoshitsugu, H., Chen, A., Rice, P., Roth, J. A., Malkinson, A. M. and Schrump, D. S. 1996. Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice. Mol. Carcinog. 17: 217-223.
35. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
36. Wolf, D. C., Gross, E. A., Lyght, O., Bermudez, E., Recio L. and Morgan, K. T. 1995. Immunohistochemical localization of p53, PCNA, and TGF-alpha proteins in formaldehyde-induced rat nasal squamous cell carcinomas. Toxicol. Appl. Pharmacol. 132: 27-35.
37. Zhang, T., Nanney, L. B., Luongo, C., Lamps, L., Heppner, K. J., DuBois, R. N. and Beauchamp, R. D. 1997. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk 4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 57: 169-175.
38. Zhou, P., Jiang, W., Zhang, Y. J., Kahn S. M., Schieren, I., Santella, R. M. and Weinstein, I. B. 1995. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene 11: 571-580.
39. Xiong, Y., Zhang, H. and Beach, D. 1992. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505-514.