Ki-ras gene mutations and absence of p53 gene mutations in spontaneous and urethane-induced early lung lesions in CBA/J mice

Molecular Carcinogenesis

Volumn 21, Issue 4, 1998, Pages 251-260

  Cazorla, Maite ^a   Hernández, Luis ^a   Fernández, Pedro L ^a   Fabra, Àngels ^b   Peinado, Miguel A ^b   Dasenbrock, Clemens ^c   Tillmann, Thomas ^d   Kamino, Kenji ^d   Campo, Elías ^a   Kohler, Manfred ^c   Morawieltz, Gerd ^c   Cardesa, Antonio ^f   Tomatis, Lorenzo ^e   Mohr, Ulrich ^d  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Institut de Recerca Oncologica   (Spain)

^c FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^f NONE

Author keywords

Carcinogenesis; Microdissection; Restriction fragment length polymorphism; Single strand conformation polymorphism analysis; Tumoral progression

Indexed keywords

PROTEIN P53; URETHAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; FEMALE; GENE EXPRESSION; GENE MUTATION; LUNG CANCER; MALE; MOUSE; NONHUMAN; ONCOGENE RAS; POINT MUTATION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADENOMA; ANIMALS; CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; CODON; DISEASE PROGRESSION; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXONS; FEMALE; GENES, P53; GENES, RAS; HYPERPLASIA; LUNG; LUNG DISEASES; LUNG NEOPLASMS; LYMPHOMA; MALE; MICE; MICE, INBRED CBA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PRECANCEROUS CONDITIONS; URETHANE;

ANIMALIA; MURINAE; RODENTIA;

EID: 2642670284     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199804)21:4<251::AID-MC4>3.0.CO;2-N     Document Type: Article

References (37)

1. Rodenhuis S, Slebos RJC. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res 52:2655-2669, 1990.
2. Viallet J, Minna J. Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer. Am J Respir Cell Mol Biol 2:225-232, 1990.
3. Rodenhuis S. ras and human tumors. Semin Cancer Biol 3:241-247, 1992.
4. Mills N, Fishman C, Rom W, Dubin N, Jacobson D. Increased prevalence of K-ras oncogene mutations in lung adenocarcinomas. Cancer Res 55:1444-1447, 1995.
5. Husgafvel-Pursiainen K, Ridanpää M, Anttila S, Vainio H. p53 and ras gene mutations in lung cancer: Implications for smoking and occupational exposures. J Occup Environ Med. 37:69-76, 1995.
6. Li Z, Zheng J, Weiss L, Shibata D. c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol 144:303-309, 1994.
7. Malkinson AM. The genetic basis of susceptibility to lung tumors in mice. Toxicology 54:241-271, 1989.
8. Shimkin MB, Stoner GD. Lung tumors in mice: Application to carcinogenesis bioassay. Adv Cancer Res 22:1-58, 1975.
9. Dragani TA, Manenti G, Pierotti MA. Genetics of murine lung tumors. Adv Cancer Res 67:83-112, 1995.
10. Nomura T. Potent mutagenicity of urethane (ethyl carbamate) gas in Drosophila melanogaster. Cancer Res 39:4224-4227, 1979.
11. Dahl GA, Miller EC, Miller JA. Comparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate and ethyl n-hydroxycarbamate. Cancer Res 40:1194-1203, 1980.
12. Leithauser MT, Leim A, Stewart BC, Miller EC, Miller JA. 1,N6-Ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate. Carcinogenesis 11:463-473, 1990.
13. You M, Candrian U, Maronpot RR, Stoner GD, Anderson MW. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. Proc Natl Acad Sci USA 86:3070-3074, 1989.
14. Ohmori H, Abe T, Hirano H, et al. Comparison of Ki-ras gene mutations among simultaneously occurring multiple urethane-induced lung tumors in individual mice. Carcinogenesis 13:851-855, 1992.
15. Re FC, Manenti G, Borrello MG, et al. Multiple molecular alterations in mouse lung tumors. Mol Carcinog 5:155-160, 1992.
16. Kawano R, Nishisaka T, Takeshima Y, Yonehara S, Inai K. Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane. Jpn J Cancer Res 86:802-810, 1995.
17. Mitsudomi T, Steinberg SM, Marion MN, et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7:171-180, 1992.
18. Hegi ME, Soderkvist P, Foley J, et al. Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice. Carcinogenesis 14:803-810, 1993.
19. Harkemá JR, Morgan KT, Renne RA, et al. Respiratory System In: Jones TC, Dungworth DL, Mohr V (eds.) Monographs on Pathology of Laboratory Animals. Springer-Verlagh, Berlin, 1996.
20. Limpens J, Beelen M, Stad R, et al. Detection of the t(14;18) translocation in frozen and formalin-fixed tissue. Diagn Mol Pathol 2:99-107, 1993.
21. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989.
22. Capella G, Cronauer-Mitra S, Peinado MA, Perucho M. Sequence and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 93:125-131, 1991.
23. Sanger F, Nicklen S, Colson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 86:5463-5467, 1977.
24. Nuzum EO, Malkinson AM, Beer DG. Specific Ki-Ras codon 61 mutations may determine the development of urethane-induced mouse lung adenomas or adenocarcinomas. Mol Carcinog 3:287-295, 1990.
25. Orita M, Iwahance H, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-stranded conformation polymorphisms. Proc Natl Acad Sci USA 86:2766-2770, 1989.
26. Goodrow TL, Storer RD, Leander KR, Prahalada SR, van Zwieten MJ, Bradley MO. Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors. Mol Carcinog 5:9-15, 1992.
27. Malkinson AM. Primary lung tumors in mice: An experimental manipulable model of human adenocarcinoma. Cancer Res 52:2670-2676, 1992.
28. Ryan J, Barker PE, Nesbitt MN, Ruddle FH. KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice. J Natl Cancer Inst 79:1351-1357, 1987.
29. Horio Y, Chen A, Rice P, Roth JA, Malkinson AM, Schrump DS. Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice. Mol Carcinog 17:217-223, 1996.
30. Ichikawa T, Yano Y, Uchida M, Otani S, Hagiwara K, Yano T. The activation of K-ras gene at an early stage of lung tumorigenesis in mice. Cancer Lett 107:165-170, 1996.
31. Westra WH, Baas IO, Hruban RH, Askin FB, Wilson K, Offerhaus JA, Slebos RJC. K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res 56:2224-2228, 1996.
32. Nelson MA, Wymer J, Clements NJ Jr. Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers. Cancer Lett 103:115-121, 1996.
33. Rumsby PC, Davies MJ, Evans JG. Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone. Mol Carcinog 9:71-75, 1994.
34. Ootsuyama A, Makino H, Nagao M, Ochiai A, Yamauchi Y, Tanooka H. Frequent p53 mutations in mouse tumors induced by repeated γ-irradiation. Mol Carcinog 11:236-242, 1994.
35. Zhang SY, Bauer D, Mitsunaga S, Goodrow TL, Klein-Szanto AJ. Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis. Mol Carcinog 12:77-81, 1995.
36. Devereoux TR, Belinsky SA, Maronpot RR, et al. Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains. Mol Carcinog 8:177-185, 1993.
37. Newcomb EW, Bayona W, Pisharody S. N-methylnitrosourea-induced Ki-ras codon 12 mutations: Early events in mouse thymic lymphomas. Mol Carcinog 13:89-95, 1995.