Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implications

American Journal of Pathology

Volumn 156, Issue 3, 2000, Pages 977-983

  Antonescu, Cristina R ^a   Leung, Denis H ^a   Dudas, Maria ^a   Ladanyi, Marc ^a   Brennan, Murray ^a   Woodruff, James M ^a   Cordon Cardo, Carlos ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN E; KI 67 ANTIGEN; PROTEIN MDM2; PROTEIN P21; PROTEIN P27; PROTEIN P53;

ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE G1 PHASE; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; DISEASE MARKER; FEMALE; GENE MUTATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SYNOVIAL SARCOMA;

EID: 0033902014     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64965-6     Document Type: Article

References (42)

1. Molecular biology of sarcomas
2. Cancer cell cycles
3. Cell cycle and cancer
4. Mutation spectrum of the p53 gene in bone and soft tissue sarcomas
5. SYT-SSX gene fusion as a determinant of morphology, and prognosis in synovial sarcoma
6. The pattern of P53 and P21(WAF/CIP1) immunoreactivity in non-Hodgkin's lymphomas predicts P53 gene status
7. Nuclear immunoreaction of p53 protein in soft tissue sarcomas
8. Mutations of cell cycle regulators: Biological and clinical implications for human neoplasia
9. Participation of p53 protein in the cellular response to DNA damage
10. Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors
11. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms
12. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas
13. Prognostic significance of Ki-67 reactivity in soft tissue sarcomas
14. Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation: A marker of metastasis?
15. Cyclin D1, and human neoplasia
16. Overexpression of Cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck
17. Overexpression of Cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
18. Cyclin D1 overexpression, and prognosis in colorectal adenocarcinoma
19. Altered G1 phase regulation in osteosarcoma
20. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis
21. Different roles for cyclin D1 and E in regulation of G1 to S transition
22. Prognostic significance of cyclin expression in osteosarcoma
23. A potential prognostic marker for breast cancer
24. Prognostic significance of Cyclin E and p53 protein overexpression in carcinoma of the renal pelvis and ureter
25. Frequent amplification of the Cyclin E gene in human gastric carcinomas
26. P53, and MDM2 alterations in osteosarcomas: Correlation with clinicopathologic features and proliferative rate
27. Tumor suppressor genes and related molecules in leiomyosarcoma
28. Molecular abnormalities of MDM2 and p53 genes in adult soft tissue sarcomas
29. WAF1, a potential mediator of p53 tumor supressor gene
30. Inhibition of cyclin-dependent kinases by p21
31. P21WAF/CIP1, and MDM2 expression in non-Hodgkin's lymphoma, and their relationship to p53 status: A p53+, MDM2-, P21- immunophenotype associated with missense p53 mutations
32. Induction of WAF1/CIP1 by a p53-independent pathway
33. P53-independent expression of P21(WAF/ CIP1) in muscle and other terminally differentiating cells
34. P53-dependent and independent expression of p21 during cell growth differentiation and DNA damage
35. Molecular analysis of the cyclin-dependent kinase inhibitor gene P27(KiP) in human malignancies
36. P27Kip: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
37. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
38. Prognostic relevance of C-terminal MDM2 detection is enhanced by P53 positivity in soft tissue sarcomas
39. Evaluation of newer prognostic markers for adult soft tissue sarcomas
40. Proliferative activity in synovial sarcoma: An immunohistochemical evaluation of Ki-67 labeling indices of 52 primary and recurrent tumors
41. Synovial sarcoma: Immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance
42. Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma