The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63- 0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum

Molecular Pharmacology

Volumn 54, Issue 3, 1998, Pages 577-583

  Boess, Frank G ^a   Riemer, Claus ^a   Bös, Michael ^a   Bentley, Jane ^a   Bourson, Anne ^a   Sleight, Andrew J ^a  

^a Preclinical Research   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO N (2,6 BISMETHYLAMINOPYRIDIN 4 YL)BENZENE SULFONAMIDE; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; 4 AMINO N (2,6 BIS METHYLAMINO PYRIDIN 4 YL) BENZENE SULFONAMIDE; 4-AMINO-N-(2,6 BIS-METHYLAMINO-PYRIDIN-4-YL)-BENZENE SULFONAMIDE; AMINOPYRIDINE DERIVATIVE; SEROTONIN 6 RECEPTOR; TRITIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG SELECTIVITY; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; ANIMAL; CORPUS STRIATUM; HELA CELL; HUMAN; METABOLISM; SPECIES DIFFERENCE; SWINE; ULTRASTRUCTURE;

AMINOPYRIDINES; ANIMALS; BINDING SITES; CORPUS STRIATUM; HELA CELLS; HUMANS; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SPECIES SPECIFICITY; SWINE; TRITIUM;

EID: 0031595682     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.577     Document Type: Article

References (22)

1. 1) receptor in a neuroblastoma X brain explant hybrid cell line (NCB-20). J Neurochem 40:977-985.
2. Boess FG and Martin IL (1994) Molecular biology of 5-HT receptors. Neuropharmacology 133:275-317.
3. 6 receptors stably expressed in HEK 293 cells. Neuropharmacology 36:713-720.
4. 6 receptor in the rat brain: a study using antisense oligonucleotides. J Pharmacol Exp Ther 274:173-180.
5. Conner DA and Mansour TE (1990) Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor. Mol Pharmacol 37:742-751.
6. 6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse 23:164-173.
7. 6 receptor-like material in the rat central nervous system. Brain Res 746:207-219.
8. 6 serotonin receptors may reflect psychoactive profile. Mol Med 1:398-406.
9. Hoyer D and Martin G (1997) 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 46:419-428.
10. 6 serotonin receptor. J Neurochem 66:47-56.
11. McPherson GA (1985) KINETIC, EBDA, LIGAND, LOWRY: a collection of radioligand binding analysis programs. Biosoft, Cambridge, UK.
12. Monsma FJ, Shen Y, Ward RP, Hamblin MW, and Sibley DR (1993) Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327.
13. Munson PJ and Rodbard D (1980) LIGAND: a versatile computerized approach for characterisation of ligand-binding systems. Anal Biochem 107:220-239.
14. Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ, Shen Y, Meltzer HY, and Sibley DR (1994) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptor. J Pharmacol Exp Ther 268: 1403-1410.
15. 6) receptor: molecular cloning, localisation and stimulation of cAMP accumulation. Biochem Biophys Res Comm 193:269-276.
16. 6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes Naunyn-Schmiedebergs Arch Pharmacol 350:356-360.
17. 6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture. Neuroreport 5:2553-2557.
18. 6 receptors. Br J Pharmacol 124:556-562.
19. 7 receptors: molecular biology, functional correlates and possible therapeutic indications. Drug News Perspect 10:214-224.
20. 6 expression in the rat: functional studies using antisense oligonucleotides. Behav Brain Res 73:245-248.
21. Unsworth CD and Molinoff PB (1994) Characterization of a 5-hydroxytryptamine receptor in mouse neuroblastoma N18TG2 cells. J Pharmacol Exp Ther 269:246-255.
22. Ward RP, Hamblin MW, Lachowicz JE, Hoffman BJ, Sibley DR, and Dorsa DM (1995) Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience 64:1105-1111.