Molecular mechanisms of glucocorticoid-induced osteoporosis

Bone

Volumn 29, Issue 6, 2001, Pages 498-505

  Patschan, D ^a   Loddenkemper, K ^a   Buttgereit, F ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Glucocorticoid induced osteoporosis; Membrane bound glucocorticoid receptors; Rapid steroid mediated effects; Steroids and hyperparathyroidism; Steroids and osteoblasts

Indexed keywords

CALCIUM; DEXAMETHASONE; GLUCOCORTICOID; MEMBRANE RECEPTOR; PARATHYROID HORMONE; PREDNISONE; SEX HORMONE; VITAMIN D;

ARTICLE; BIOSYNTHESIS; BONE ATROPHY; BONE DENSITY; BONE INJURY; BONE REMODELING; CALCIUM BALANCE; CELL FUNCTION; DRUG EFFECT; DRUG MECHANISM; GENOME; GONAD FUNCTION; HUMAN; INTESTINE ABSORPTION; MOLECULAR DYNAMICS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; PATHOGENESIS; PROTEIN BINDING; SECONDARY HYPERPARATHYROIDISM; URINARY EXCRETION;

CALCIUM; GLUCOCORTICOIDS; GONADAL STEROID HORMONES; HUMANS; INTESTINAL ABSORPTION; KIDNEY; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; PARATHYROID HORMONE; VITAMIN D;

EID: 0035205516     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00610-X     Document Type: Article

References (75)

1. Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney
2. Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action
3. Cortisol stimulation of parathyroid hormone secretion by rat parathyroid glands in organ culture
4. 11-beta-Hydroxysteroid dehydrogenase in the rat ovary: High expression in the oocyte
5. Effects of IGF-I combined with GH on glucocorticoid-induced changes of bone and connective tissue turnover in man
6. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
7. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone
8. Effects of interleukin-1 on bone turnover in normal mice
9. Equivalent doses and relative drug potencies for nongenomic glucocorticoid effects
10. Bioenergetics of immune functions: Fundamental and therapeutic aspects
11. The effects of methylprednisolone on oxidative phosphorylation in Concanavalin-A-stimulated thymocytes. Top-down elasticity analysis and control analysis
12. + ions into concanavalin A-stimulated thymocytes
13. A new hypothesis of modular glucocorticoid actions: Steroid treatment of rheumatic diseases revisited
14. Short-term effect of prednisone on serum 1,25-dihydroxyvitamin D in normal individuals and in hyper- and hypoparathyroidism
15. Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone
16. Mechanism of the regulation of the 1 alpha,25- dihydroxyvitamin D3 receptor in the rat jejunum by glucocorticoids
17. Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid
18. Association of the glucocorticoid receptor alternatively-spliced transcript 1A with the presence of the high molecular weight membrane glucocorticoid receptor in mouse lymphoma cells
19. Multiple glucocorticoid receptor transcripts in membrane glucocorticoid receptor-enriched S-49 mouse lymphoma cells
20. Reduction of serum-1, 25-dihydroxyvitamin-D3 in children receiving glucocorticoids
21. Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation
22. Calcium absorption in corticoid treated subjects effects of a single oral dose of calcitriol
23. Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: Regulation by insulin and glucocorticoid
24. Differential effects of glucocorticoid on recruitment and activity of osteoclasts induced by normal and osteocalcin-deficient bone implanted in rats
25. Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells
26. Mechanisms of glucocorticoid action in bone cells
27. Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors
28. The osteoblast: A sophisticated fibroblast under central surveillance
29. Intestinal calcium-binding protein and calcium absorption in cortisol-treated chicks: Effects of vitamin D3 and 1,25-dihydroxyvitamin D3
30. Cortisol inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures by transcriptional mechanisms
31. Developmental changes in glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells
32. Effects of prednisone and Deflazacort on mineral metabolism and parathyroid hormone activity in humans
33. Effects off short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man
34. The effect of long- and short-term corticosteroids on plasma calcitonin and parathyroid hormone levels
35. Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function
36. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis
37. Increased osteoclast development after estrogen loss: Mediation by interleukin-6
38. Dexamethasone stimulates osteoclast-like cell formation by directly acting on hemopoietic blast cells and enhances osteoclast-like cell formation stimulated by parathyroid hormone and prostaglandin E2
39. Effect of cortisone treatment on the active transport of calcium by the small intestine
40. Intestinal calcium absorption in exogenous hypercortisonism. Role of 25-hydroxyvitamin D and corticosteroid dose
41. The effects of chronic prednisone administration on intestinal receptors for 1,25-dihydroxyvitamin D3 in the dog
42. Dexamethasone alters rapidly actin polymerization dynamics in human endometrial cells: Evidence for nongenomic actions involving cAMP turnover
43. Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis
44. Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse. MC3T3-E1 osteoblasts: Dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression
45. Therapeutic implications of non-genomic glucocorticoid activity
46. Intestinal calcium absorption and parathyroid hormone secretion in asthmatic patients on prolonged oral or inhaled steroid treatment
47. Glucocorticoid-induced osteoporosis: Pathogenesis and management
48. New developments in the pathogenesis and treatment of steroid-induced osteoporosis
49. A working hypothesis for the regulation of steroidogenesis and germ cell development in the gonads by glucocorticoids and 11 beta-hydroxysteroid dehydrogenase (11 beta HSD)
50. Direct inhibition of ovarian steroidogenesis by cortisol and the modulatory role of 11 beta-hydroxysteroid dehydrogenase
51. Comparative aspects of 11 beta-hydroxysteroid dehydrogenase. Testicular 11 beta-hydroxysteroid dehydrogenase: Development of a model for the mediation of Leydig cell function by corticosteroids
52. 11 beta-hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells
53. Intact parathyroid hormone levels are not elevated in glucocorticoid-treated subjects
54. Dexamethasone increases preproparathyroid hormone messenger RNA in human hyperplastic parathyroid cells in vitro
55. Glucocorticoid osteoporosis - Mechanisms and management
56. Evidence for decreased tubular reabsorption of calcium in glucocorticoid-treated asthmatics
57. Testosterone therapy in glucocorticoid-treated men
58. Cellular regulatory mechanisms that may underlie the effects of corticosteroids on bone
59. Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures
60. Glucocorticoid dose dependent downregulation of glucocorticoid receptors in patients with rheumatic diseases
61. Rapid, nongenomic steroid actions: A new age?
62. Sex steroids and osteoporosis: Effects of deficiencies and substitutive treatments
63. Decreased intestinal calcium absorption in vivo and normal brush border membrane vesicle calcium uptake in cortisol-treated chickens: Evidence for dissociation of calcium absorption from brush border vesicle uptake
64. Cortisol decreases hepatocyte growth factor levels in human osteoblast-like cells
65. Parathyroid hormone and 25-hydroxyvitamin D levels in glucocorticoid-treated patients
66. Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto-oncogenes in normal human osteoblast-like cells
67. Effect of hydrocortisone on osteoclasts generated in cat bone marrow cultures
68. Combined effects of dexamethasone and 1,25-dihydroxyvitamin D3 on parathyroid hormone secretion in cultured bovine parathyroid cells
69. Cortisol decreases IGF-I mRNA levels in human osteoblast-like cells
70. Effects of cortisol on the expression of interleukin-6 and interleukin-1 beta in human osteoblast-like cells
71. Bone resorption by osteoclasts
72. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids
73. Basal activities and hormone responsiveness of osteoclast-like and osteoblast-like bone cells are regulated by glucocorticoids
74. Prednisolone induces an increase in serum calcium concentration: Possible involvement of the kidney, the bone, and the intestine
75. Glucocorticoid-induced osteoporosis: Prevention and treatment