Dexamethasone stimulates osteoclast-like cell formation by directly acting on hemopoietic blast cells and enhances osteoclast-like cell formation stimulated by parathyroid hormone and prostaglandin E2

Journal of Bone and Mineral Research

Volumn 12, Issue 5, 1997, Pages 734-741

  Kaji, Hiroshi ^a   Sugimoto, Toshitsugu ^a   Kanatani, Masanori ^a   Nishiyama, Katsuhito ^a   Chihara, Kazuo ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; FLUOROURACIL; FORSKOLIN; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; HEMATOPOIESIS; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PROSTAGLANDIN BLOOD LEVEL;

EID: 0030969096     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.5.734     Document Type: Article

References (29)

1. Curtiss PH, Clark WS, Herndon CH 1954 Vertebral fractures resulting from prolonged cortisone and corticotropin therapy. JAMA 156:467-469.
2. Hahn TJ, Halstead LR, Teitelbaum SL, Hahn BH 1979 Altered mineral metabolism in glucocorticoid-induced osteopenia. J Clin Invest 64:655-665.
3. Bressot CP, Meunier J, Lejeune E, Edouard C, Darby AJ 1979 Histomorphometric profile, pathophysiology and reversibility of glucocorticoid-induced osteoporosis. Metab Bone Dis Re1 Res 1:303-311.
4. Burckhardt P 1984 Corticosteroid and bone: A review. Horm Res 20:59-64.
5. Raisz LG, Trummel CL, Werner JA, Simmons H 1972 Effect of glucocorticoids on bone resorption in tissue culture. Endocrinology 90:961-967.
6. 45Ca release from embryonic rat bone in vitro. J Pharmacol Exp Ther 168:211-217.
7. Tobias J, Chambers TJ 1989 Glucocorticoids impair bone resorptive activity and viability of osteoclasts disaggregated from neonatal rat long bones. Endocrinology 125:1290-1295.
8. Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T 1990 Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 87:7260-7264.
9. Reid IR, Katz JM, Ibbertson HK, Gray DH 1985 The effects of hydrocortisone, parathyroid hormone and the bisphosphonate, APD on bone resorption in neonatal mouse calvaria. Calcif Tissue Int 38:38-43.
10. Shuto T, Kukita T, Hirata M, Jimi E, Koga T 1994 Dexamethasone stimulates osteoclast-like cell formation by inhibiting granulocyte-macrophage colony-stimulating factor production in mouse bone marrow cultures. Endocrinology 134:1121-1126.
11. Gronowicz G, McCarthy MB, Raisz LG 1990 Glucocorticoids stimulate resorption in fetal rat parietal bones in vitro. J Bone Miner Res 5:1223-1230.
12. Urena P, Iida-Klein A, Kong XF, Juppner H, Kronenberg HM, Abou-Samra AB, Segre GV 1994 Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells. Endocrinology 134:451-456.
13. Godschalk M, Levy JR, Downs RW Jr 1992 Glucocorticoids decrease vitamin D receptor number and gene expression in human osteosarcoma cells. J Bone Miner Res 7:21-27.
14. Wada S, Akatsu T, Tamura T, Takahashi N, Suda T, Nagata N 1994 Glucocorticoid regulation of calcitonin receptor in mouse osteoclast-like multinucleated cells. J Bone Miner Res 9:1705-1712.
15. Takada Y, Kusuda M, Hiura K, Sato T, Mochizuki H, Nagao Y, Tomura M, Yahiro M, Hakeda Y, Kawashima H, Kumegawa M 1992 A simple method to assess osteoclast-mediated bone resorption using unfractionated bone cells. Bone Miner 17:347-359.
16. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080.
17. Kanatani M, Sugimoto T, Fukase M, Chihara K 1994 Role of interleukin-6 and prostaglandins in the effect of monocyte-conditioned medium on osteoclast formation. Am J Physiol 267:E868-E876.
18. Kaji H, Sugimoto T, Kanatani M, Fukase M 1992 The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone. Biochem Biophys Res Commun 182:1356-1361.
19. Kurihara N, Suda T, Miura Y, Nakauchi H, Kodama H, Hiura K, Hakeda Y, Kumegawa M 1989 Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 74:1295-1302.
20. Sugimoto T, Kanatani M, Kaji H, Yamaguchi T, Fukase M, Chihara K 1993 Second messenger signaling of PTH- and PTHrP-stimulated osteoclast-like cell formation from hemopoietic blast cells. Am J Physiol 265:E367-E373.
21. Hodgson GS, Bradley TR 1979 Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: Evidence for a pre-CFU-S cell. Nature 281:381-382.
22. 2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoclasts: Role of cAMP-dependent protein kinase. J Bone Miner Res 11:62-71.
23. Hakeda Y, Hiura K, Sato T, Okazaki R, Matsumoto T, Ogata E, Ishitani R, Kumegawa M 1989 Existence of parathyroid hormone binding sites on murine hemopoietic blast cells. Biochem Biophys Res Commun 163:1481-1486.
24. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T 1989 The bone marrow-derived stromal cell lines MC3T3/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805-1813.
25. Hattersley G, Chambers TJ 1989 Calcitonin receptors as markers for osteoclast differentiation: Correlation between generation of bone-resorptive cells and cells that express calcitonin receptors in mouse bone marrow cultures. Endocrinology 125:1606-1612.
26. Lorenzo JA, Sousa SL, Fonseca JM, Hook JM, Medlock ES 1987 Colony-stimulating factors regulated the development of multinucleated osteoclasts from recently replicated cells in vitro. J Clin Invest 80:160-164.
27. Kaji H, Sugimoto T, Kanatani M, Miyauchi A, Kimura T, Sakakibara S, Fukase M, Chihara K 1994 Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity. Endocrinology 134:1897-1904.
28. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K 1995 Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology 136:842-848.
29. Kaji H, Sugimoto T, Kanatani M, Fukase M, Kumegawa M, Chihara K 1995 Retinoic acid induces osteoclast-like cell formation by directly acting on hemopoietic blast cells and stimulates osteopontin mRNA expression in isolated osteoclasts. Life Sci 56:1903-1913.