T-cell lineage fate: Instructed by receptor signals?

Current Biology

Volumn 10, Issue 17, 2000, Pages

  Von Boehmer, Harald ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034618566     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00665-5     Document Type: Review

References (16)

1. Lck activity controls CD4/CD8 T cell lineage commitment
2. Inducible expression of a p56(lck) transgene reveals a central role for lck in the differentiation of CD4 SP thymocytes
3. + T cell lineage fate
4. + T cells
5. Thymic major histocompatibility complex antigens and the αβ T cell receptor determine the CD4/CD8 phenotype of T cells
6. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
7. The selection of the αβ heterodimeric T cell receptor for antigen
8. Another view of the selective model of thymocyte selection
9. The regulation of CD4 and CD8 coreceptor gene expression during T cell development
10. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
11. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
12. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
13. + helper T cells in class II MHC mutant mice
14. + thymocytes in suspension culture
15. + single positive-cells with a class II MHC-restricted receptor
16. Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment