Towards global and long-term neurological gene therapy: Unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS

Molecular Therapy

Volumn 4, Issue 5, 2001, Pages 490-498

  Zermansky, Adam J ^a   Bolognani, Federico ^a   Stone, Daniel ^a,b   Cowsill, Christine M ^a   Morrissey, Graham ^a   Castro, Maria G ^a,c   Löwenstein, Pedro R ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Research Pavillion   (United States)

Author keywords

Adenovirus; Brain; HSV1 TK; Transgene specific

Indexed keywords

BETA GALACTOSIDASE; THYMIDINE KINASE; VIRUS ENZYME; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENETIC CODE; HERPES SIMPLEX VIRUS 1; IMMUNOREACTIVITY; INJECTION SITE; LONG TERM CARE; LONGEVITY; MALE; NONHUMAN; RAT; TRANSGENE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALIA; HERPES; HUMAN HERPESVIRUS 1; RODENTIA;

EID: 0035189417     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0479     Document Type: Article

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