The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: Glucocorticoid-induced PPARα is linked to peroxisome proliferator mitogenesis

Carcinogenesis

Volumn 19, Issue 5, 1998, Pages 925-931

  Plant, Nicholas J ^e   Horley, Neill J ^e   Savory, Richard L ^a   Elcombe, Clifford R ^b,c   Gray, Tim J B ^d   Bell, David R ^e  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d Sanofi Winthrop   (United Kingdom)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; CLOFIBRATE; DNA; EPIDERMAL GROWTH FACTOR; GLUCOCORTICOID; HYDROCORTISONE; METHYLCLOFENAPATE; MITOGENIC AGENT; PEROXISOME PROLIFERATOR; PIRINIXIC ACID;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CULTURE; MALE; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CLOFENAPATE; CLOFIBRATE; DNA REPLICATION; GLUCOCORTICOIDS; GROWTH SUBSTANCES; LIVER; MALE; MICROBODIES; MITOGENS; PYRIMIDINES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFIDES; TRANSCRIPTION FACTORS;

EID: 0031815538     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.5.925     Document Type: Article

References (28)

1. Lock,E.A., Mitchell,A.M. and Elcombe,C.R. (1982) Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annn. Rev. Pharmacol. Toxicol.,29, 145-163.
2. Reddy,J.K., Azarnoff,D.L. and Hignite,C.E. (1980) Hypolipidaemic peroxisome proliferators form a novel class of chemical carcinogen. Nature, 283, 397-398.
3. Styles,J.A., Kelly,M. and Elcombe,C.R. (1988) A species comparison of acute hyperplasia induced by the peroxisome proliferator, methyl-clofenapate: involvement of the binucleated hepatocyte. Carcinogenesis, 9, 1647-1655.
4. Barrass,N.C., Pric,R.J., Lake,B.G. and Orton,T.C. (1993) Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methyl-clofenapate and clofibric acid in rat liver. Carcinogenesis, 14, 1451-1456.
5. Ashby,J., Brady,A., Elcombe,C.R., Elliott,B.M., Ishmael,J., Odum,J., Tugwood,J.D., Kettle,S. and Purchase,I.F.H. (1994) Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Human Exp. Toxicol., 13, S1-S117.
6. Marsman,D.S., Cattley,R.C., Conway,J.G. and Popp,J.A. (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl) phthalate and Wy-14 643 in rats. Cancer Res., 48, 6739-6744.
7. Kliewer,S.A., Forman,B.M., Blumberg,B., Ong,E.S., Borgmeyer,U., Mangelsdorf,D.J., Umesono,K. and Evans,R.M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl Acad. Sci. USA, 91, 7355-7359.
8. Lee,S.-T., Pineau,T., Drago,J. et al (1995) Targeted disruption of the isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell Biol., 15, 3012-3022.
9. Styles,J.A., Kelly,M.D., Pritchard,N.R. and Foster,J.R. (1990) Effects produced by the non-genotoxic hepatocarcinogen methylclofenapate in dwarf mice: peroxisome proliferation uncoupled from DNA synthesis and nuclearity changes. Carcinogenesis, 11, 387-391.
10. Bell,D.R., Bars,R.G., Gibson,G.G. and Elcombe,C.R. (1991) Localisation and differential induction of P450 IVA1 and acyl-CoA oxidase in rat liver. Biochem. J., 275, 247-252.
11. Michalopoulos,G.K. (1990) Liver regeneration: molecular mechanisms of growth control. FASEB J., 4, 176-187.
12. Marsman,D.S., Swanson-Pfeiffer,C.L. and Popp,J.A. (1993) Lack of comitogenicity by the peroxisome proliferator hepatocarcinogens, Wy-14 643 and clofibric acid. Toxicol. Appl. Pharmacol., 122, 1-6.
13. Bieri,F., Bentley,P., Waechter,F. and Staubli,W. (1984) Use of primary cultures of adult rat hepatocytes to investigate mechanisms of action of nafenopin, a hepalocarcinogenic peroxisome proliferator. Cardnogenesis, 5, 1033-1039.
14. Bennett,A.M. and Williams,G.M. (1993) Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochem. Pharmacol., 46, 2219-2227.
15. James,N.H. and Roberts,R.A. (1994) The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. Carcinogenesis, 15, 2687-2694.
16. Mitchell,A.M., Bridges,J.W. and Elcombe,C.R. (1984) Factors influencing peroxisome proliferation in cultured rat hepatocytes. Arch. Toxicol., 55, 239-246.
17. Bell,D.R. and Elcombe,C.R. (1991). Induction of acyl-CoA oxidase and cytochrome P450 4A1 RNA in primary cultures of rat hepatocytes. Biochem. J., 281, 249-253.
18. Jones,PS., Savory,R., Bell,A.R., Barratt,P., Jenkins,N.A., Copeland,N.G., Gray,T.J.B. and Bell,D.R. (1995) Chromosomal localisation, inducibility, tissue-specificity and strain differences in three murine PPARs. Eur. J. Biochem., 233, 219-226.
19. Gorski,K., Carneiro,M. and Schibler,U. (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell, 47, 767-776.
20. Gottlicher,M., Widmark,E., Li,Q. and Gustafson,J.A. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl Acad. Sci. USA, 89, 4653-4657.
21. Bars,R.G., Bell,D.R. and Elcombe,C.R. (1993) Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochem. Pharmacol., 45, 2045-2053.
22. Steineger,H.H., Sørenson,H.N., Tugwood,J.D., Skrede,S., Spydevold,Ø. and Gautvik,K.M. (1994) Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Eur. J. Biochem., 225, 967-974.
23. Bars,R.G., Bell,D.R., Elcombe,C.R., Oinonen,T., Jalava,T. and Lindros,K.O. (1992) Zone-specific inducibility of cytochrome P450 2B1/ 2 is retained irt isolated perivenous hepatocytes. Biochem. J., 282, 635-638.
24. Ni,N. and Yager,J.D. (1994) Comitogenic effects of estrogens on DNA synthesis induced by various growth factors in cultured female rat hepatocytes. Hepatology, 19, 183-192.
25. Lindroos,P. and Michalopoulos,G.K. (1993) Response of phenobarbital and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels. Carcinogenesis, 14, 731-735.
26. Lemberger,T., Staels,B., Saladin,R., Desvergne,B., Auwerx,J. and Wahli,W. (1994) Regulation of the peroxisome proliferator-activated receptor gene by glucocorticoids. J. Biol. Chem., 269, 24527-24530.
27. Tugwood,J.T., Issemann,I., Anderson,R.G., Bundell,K.R., Mcpheat,W.L. and Green,S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl-CoA oxidase gene. EMBO J., 11, 433-439.
28. Hong,J.T. and Glauert,H.P. (1995) Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. J. Cell. Physiol., 169, 309-319.