Local inflammation and devascularization - In vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma

Cancer Gene Therapy

Volumn 8, Issue 11, 2001, Pages 843-851

  Floeth, Frank W ^a   Shand, Nick ^b   Bojar, Hans ^a   Prisack, Hans B ^a   Felsberg, Jörg ^a   Neuen Jacob, Eva ^a   Aulich, Albrecht ^a   Burger, Klaus J ^c   Bock, Wolfgang J ^a   Weber, Friedrich ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Novartis Pharma AG   (Germany)

Author keywords

Bystander effect; Endothelial transfection; HSV Tk; Human malignant glioma; Immune response; Vector producer cells

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DEVASCULARIZATION; ENDOTHELIUM CELL; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GLIOBLASTOMA; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MALE; NECROSIS; PRIORITY JOURNAL; PROGNOSIS; RETROVIRUS; SUICIDE GENE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN; BRAIN NEOPLASMS; BYSTANDER EFFECT; ENCEPHALITIS; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; GLIOMA; HERPESVIRUS 1, HUMAN; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; RETROVIRIDAE; THYMIDINE KINASE; TRANSFECTION;

HERPES; HUMAN HERPESVIRUS 1; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0035184536     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700382     Document Type: Article

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