DiSSiMil: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody

Journal of Peptide Research

Volumn 57, Issue 1, 2001, Pages 68-76

  Burgess, K ^a   Han, I ^a   Zhang, A ^a   Zheng, W H ^b   Saragovi, H U ^b,c   Shanmugam, K ^c   Featherstone, M S ^c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Binding; Drug discovery; Epitope mapping; Peptide library

Indexed keywords

ALANINE; AMINO ACID; GLYCINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 10D11; PENTAPEPTIDE; PEPTIDE LIBRARY; PROLYLTRYPTOPHYLGLYCYLGLYCYLGLYCINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXD4; TRYPTOPHYLLYSYLGLYCYLGLYCYLGLYCINE; UNCLASSIFIED DRUG; VALYLTYROSYLGLYCYLGLYCYLGLYCINE;

ARTICLE; ASSAY; CONTROLLED STUDY; EPITOPE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CHEMISTRY; EPITOPE MAPPING; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE LIBRARY; PEPTIDES; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; TRANSCRIPTION FACTORS;

EID: 0035177790     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00786.x     Document Type: Article

References (41)

1. Design and synthesis of a mimetic from an antibody complementarity-determining region
2. Loops and secondary structure mimetics: Development and applications in basic science and rational drug design
3. Exploring antibody polyspecificity using synthetic combinatorial libraries
4. The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells
5. Exploring immunological specificity using synthetic peptide combinatorial libraries
6. Epitope mapping by phage display: Random versus gene-fragment libraries
7. Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei
8. Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries
9. Antigen sequence- and library-based mapping of linear and discontinuous protein-protein-interaction sites by spot synthesis
10. Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme
11. Energetic and kinetic contributions of contact residues of antibody D1.3 in the interaction with lysozyme
12. Solution structure and internal motion of a bioactive peptide derived from nerve growth factor
13. Anatomy of an antibody molecule: Structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody D1.3
14. Rapid refinement of protein interfaces incorporating solvation: Application to the docking problem
15. Functional and physical association of a cell surface phospholipid and interleukin-2 receptor p55 (alpha) subunits
16. Fragment reconstitution of a small protein: Folding energetics of the reconstituted immunoglobulin binding domain B1 of streptococcal protein G
17. Residues flanking the HOX YPWM motif contribute to cooperative interactions with PBX
18. Solid-phase synthesis of protected peptide fragments using a trialkoxydiphenyl-methylester resin
19. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
20. PyBOP: A new peptide coupling reagent devoid of toxic by-product
21. Optimal nerve growth factor trophic signals mediated by synergy of TrkA and P75 receptor-specific ligands
22. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
23. Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers
24. Protein A mimetic peptide ligand for affinity purification of antibodies
25. Peptide ligands that bind IgM antibodies and block interaction with antigen
26. Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library
27. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å
28. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
29. Minimization of a polypeptide hormone
30. Thermodynamic characterization of affinity maturation: The D1.3 antibody and a higher-affinity mutant
31. Structural insights into the evolution of an antibody combining site
32. On the importance of being aromatic at an antibody-protein antigen interface: Mutagenesis of the extracellular interferon gamma receptor and recognition by the neutralizing antibody A6
33. On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands
34. The epitopes for natural polyreactive antibodies are rich in proline
35. Antibody-antigen interactions: Contact analysis and binding site topography
36. Hormone mimicry
37. Identifying structure-function relationships in four-helix bundle cytokines: Towards de novo mimetics design
38. The glycopeptide story - How to kill the deadly 'superbugs'
39. Epitope mapping by screening of phage display libraries of a monoclonal antibody directed against the receptor binding domain of human alpha2-macroglobulin