Exploring antibody polyspecificity using synthetic combinatorial libraries

Molecular Diversity

Volumn 2, Issue 1-2, 1996, Pages 29-34

  Appel, Jon R ^a   Buencamino, Jaime ^a   Houghten, Richard A ^a   Pinilla, Clemencia ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Monoclonal antibodies; Polyspecificity; Positional scanning; Synthetic combinatorial libraries

Indexed keywords

EPITOPE; FIBRINOGEN; FLAG PEPTIDE; HEPATITIS B SURFACE ANTIGEN; MONOCLONAL ANTIBODY; ONCOPROTEIN; PEPTIDE; PEPTIDE LIBRARY; PROTEIN KINASE FES; PROTEIN TYROSINE KINASE; WNT PROTEIN; ZEBRAFISH PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; CHEMISTRY; IMMUNOLOGY; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; EPITOPES; FIBRINOGEN; HEPATITIS B SURFACE ANTIGENS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS V-ERBB; PEPTIDE LIBRARY; PEPTIDES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FES; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0030252455     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01718697     Document Type: Article

References (29)

1. Christian, R.B., Zuckermann, R.N., Kerr, J.M., Wang, L. and Malcolm, B.A., Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage, J. Mol. Biol., 227 (1992) 711-718.
2. Felici, F., Castagnoli, L., Musacchio, A., Jappelli, R. and Cesareni, G., Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition rector, J. Mol. Biol., 222 (1991) 301-310.
3. Needels, M.C., Jones, D.G., Tate, E.H., Heinkel, G.L., Kochersperger, L.M., Dower, W.J., Barrett, R.W. and Gallop, M.A., Generation and screening of an oligonucleotide-encoded synthetic peptide library, Proc. Natl. Acad. Sci. USA, 90 (1993) 10700-10704.
4. Scott, J.K. and Smith, G.P., Searching for peptide ligands with an epitope library, Science, 249 (1990) 386-390.
5. Pinilla, C., Buencamino, J., Appel, J.R., Hopp, T.P. and Houghten, R.A., Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: Identification of potent calcium-independent antigens, Mol. Diversity, 1 (1995) 21-28.
6. Pinilla, C., Buencamino, J., Appel, J.R., Houghten, R.A., Brassard, J.A. and Ruggeri, Z.M., Two antipeptide monoclonal antibodies that recognize adhesive sequences in fibrinogen: Identification of antigenic determinants and unrelated sequences using synthetic combinatorial libraries, Biomed. Pept. Protein Nucleic Acids, 1 (1995) 199-204.
7. Pinilla, C., Chendra, S., Appel, J.R. and Houghten, R.A., Elucidation of monoclonal antibody polyspecificity using synthetic combinatorial library, Pept. Res., 8 (1995) 250-257.
8. Van Regenmortel, M.H.V., Transcending the structuralist paradigm in immunology - affinity and biological activity rather than purely structural considerations should guide the design of synthetic peptide epitopes, Biomed. Pept. Protein Nucleic Acids, 1 (1995) 109-116.
9. Pinilla, C., Appel, J., Blondelle, S.E., Dooley, C.T., Dörner, B., Eichler, J., Ostresh, J.M. and Houghten, R.A., A review of the utility of peptide combinatorial libraries, Biopolym. Pept. Sci. Sect., 37 (1995) 221-240.
10. Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T. and Cuervo, J.H., Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery, Nature, 354 (1991) 84-86.
11. Pinilla, C., Appel, J.R., Blanc, P. and Houghten, R.A., Rapid identification of high-affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries, Biotechniques, 13 (1992) 901-905.
12. Ostresh, J.M., Winkle, J.H., Hamashin, V.T. and Houghten, R.A., Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings, Biopolymers, 34 (1994) 1681-1689.
13. Dooley, C.T. and Houghten, R.A., The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands, Life Sci., 52 (1993) 1509-1517.
14. Houghten, R.A., General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids, Proc. Natl. Acad. Sci. USA, 82 (1985) 5131-5135.
15. Pinilla, C., Appel, J.R. and Houghten, R.A., Functional importance of amino acid residues making up peptide antigenic determinants, Mol. Immunol., 30 (1993) 577-585.
16. Pinilla, C., Appel, J.R. and Houghten, R.A., Identification of antigenic determinants using synthetic peptide combinatorial libraries, In Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W. (Eds.) Current Protocols in Immunology, Wiley, New York, NY, U.S.A., 1994, pp. 9.8.1-9.8.15.
17. Appel, J.R., Muller, S., Benkirane, N., Houghten, R.A. and Pinilla, C., Highly specific, crossreactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library, Pept. Res., (1996) in press.
18. Appel, J.R., Pinilla, C., Niman, H. and Houghten, R.A., Elucidation of discontinuous linear determinants in peptides, J. Immunol., 144 (1990) 976-983.
19. Appel, J.R., Buencamino, J., Houghten, R.A. and Pinilla, C., Mapping the specificity of an antibody against an oncogenic sequence using peptide combinatorial libraries and substitution analogs: Implications for breast cancer detection, In Kaumaya, P.T.P. and Hodges, R.S. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 14th American Peptide Symposium), Mayflower Scientific Ltd., Kingswinford, U.K., 1996, pp. 794-795.
20. Pinilla, C., Appel, J.R. and Houghten, R.A., Synthetic peptide combinatorial libraries (SPCLs): Identification of the antigenic determinant of β-endorphin recognized by monoclonal antibody 3 E7, Gene, 128 (1993) 71-76.
21. Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Ostresh, J.M. and Houghten, R.A., Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds, Drug Dev. Res., 33 (1994) 133-145.
22. Appel, J.R., Pinilla, C. and Houghten, R.A., Identification of related peptides recognized by a monoclonal antibody using a synthetic peptide combinatorial library, Immunomethods, 1 (1992) 17-23.
23. Getzoff, E.D., Tainer, J.A., Lerner, R.A. and Geysen, H.M., The chemistry and mechanism of antibody binding to protein antigens, Adv. Immunol., 43 (1988) 1-98.
24. Geysen, H.M., Mason, T.J. and Rodda, S.J., Cognitive features of continuous antigenic determinants, J. Mol. Recog., 2 (1989) 32-49.
25. Rini, J.M., Schulze-Gahmen, U. and Wilson, I.A., Structural evidence for induced fit as a mechanism for antibody-antigen recognition, Science, 255 (1992) 959-965.
26. Churchill, M.E.A., Stura, E., Pinilla, C., Appel, J.R., Houghten, R.A., Kono, D.H., Balderas, R.S., Fieser, G.G., Schulze-Gahmen, U. and Wilson, I.A., Crystal structure of a peptide complex of antiinfluenza peptide antibody Fab 26/9: Comparison of two different antibodies bound to the same peptide antigen, J. Mol. Biol., 241 (1994) 534-556.
27. Ostresh, J.M., Husar, G.M., Blondelle, S.E., Dörner, B., Weber, P.A. and Houghten, R.A., 'Libraries from libraries': Chemical transformation of combinatorial libraries to eXtend the range and repertoire of chemical diversity, Proc. Natl. Acad. Sci. USA, 91 (1994) 11138-11142.
28. Dooley, C.T. and Houghten, R.A., Identification of μ-selective polyamine antagonists from a synthetic combinatorial library, Analgesia, 1 (1995) 400-404.
29. Eichler, J., Appel, J.R., Blondelle, S.E., Dooley, C.T., Dörner, B., Ostresh, J.M., Pérez-Payá, E., Pinilla, C. and Houghten, R.A., Peptide, peptidomimetic and organic synthetic combinatorial libraries, Med. Res. Rev., 15 (1995) 481-496.