Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention

Journal of Cell Biology

Volumn 136, Issue 2, 1997, Pages 287-297

  Bryant, Nia J ^a   Stevens, Tom H ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; MEMBRANE PROTEIN;

ARTICLE; CELL ORGANELLE; GOLGI COMPLEX; INFORMATION RETRIEVAL; MEMBRANE BINDING; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ALKALINE PHOSPHATASE; CELL COMPARTMENTATION; CYTOSOL; FUNGAL PROTEINS; GOLGI APPARATUS; MEMBRANE PROTEINS; PEPTIDYL-DIPEPTIDASE A; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; VACUOLES;

SACCHAROMYCES CEREVISIAE;

EID: 0031055434     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.136.2.287     Document Type: Article

References (51)

1. Becherer, K.A., S.E. Rieder, S.D. Emr, and E.W. Jones. 1996. Novel syntaxin homologue, Pep12p, required for the sorting of tumenal hydrolases to the lysosome-like vacuole in yeast. Mol. Biol. Cell. 7:579-594.
2. Blum, J.S., M.L. Fiani, and P.D. Stahl. 1991. Localization of cathepsin D in endosomes: characterization and biological importance. Adv. Exp. Med. Biol. 306:281-287.
3. Bos, K., C. Wraight, and K.K. Stanley. 1993. TGN38 is maintained in the transGolgi network by a tyrosine-containing motif in the cytoplasmic domain. EMBO (Eur. Mol. Biol. Organ.) J. 12:2219-2228.
4. Bretscher, M.S., and S. Munro. 1993. Cholesterol and the Golgi apparatus. Science (Wash. DC). 261:1280-1281.
5. Bryant, N.J., and A. Boyd. 1993. Immunoisolation of Kex2p-containing organelles from yeast demonstrates colocalisation of three processing proteinases to a single Golgi compartment. J. Cell Sci. 106:815-822.
6. Canfield, W.M., R.D. Johnson, R.D. Ye, W. Gregory, and S. Kornfeld. 1991. Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail. J. Biol. Chem. 266:5682-5688.
7. Cereghino, J.L., E.G. Marcusson, and S.D. Emr. 1995. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol. Biol. Cell. 6:1089-1102.
8. Chapman, R.E., and S. Munro. 1994. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. EMBO (Eur. Mol. Biol. Organ.) J. 13:4896-4907.
9. Cooper, A.A., and H. Bussey. 1992. Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane. J. Cell Biol. 119:1459-1468.
10. Cooper, A.A., and T.H. Stevens. 1996. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. J. Cell Biol. 133:529-541.
11. Franzusoff, A., K. Redding, J. Crosby, R.S. Fuller, and R. Schekman. 1991. Localization of components involved in protein transport and processing through the yeast Golgi apparatus. J. Cell Biol. 112:27-37.
12. Graham, T.R., and S.D. Emr. 1991. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J. Cell Biol. 114:207-218.
13. Graham, T.R., and V.A. Krasnov. 1995. Sorting of yeast alpha 1,3 mannosyltransferase is mediated by a lumenal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein. Mol. Biol. Cell. 6:809-824.
14. Harris, S., and M.G. Waters. 1996. Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport. J. Cell Biol. 132:985-988.
15. Humphrey, J.S., P.J. Peters, L.C. Yuan, and J.S. Bonifacino. 1992. Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence. J. Cell Biol. 120:1123-1135.
16. Kilonsky, D.J., and S.D. Emr. 1989. Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO (Eur. Mol. Biol. Organ.) J. 8:2241-2250.
17. Kornfeld, S. 1992. Structure and function of the mannose-6-phosphate/insulin growth factor-II receptors. Annu. Rev. Biochem. 61:307-330.
18. Kunkel, T.A., J.D. Roberts, and R.A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
19. Lewis, M.J., and H.R. Pelham. 1992. Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Cell. 68:353-364.
20. Lussier, M., M. Sdicu, T. Ketela, and H. Bussey. 1995. Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p alpha 1,2-mannosyltransferase to a medial-Golgi compartment. J. Cell Biol. 131:913-927.
21. Machamer, C.E., M.G. Grim, A. Esquela, S.W. Chung, M. Rolls, K. Ryan, and A.M. Swift. 1993. Retention of a cis-Golgi protein requires polar residues on one face of a predicted alpha-helix in the transmembrane domain. Mol. Biol. Cell. 4:695-704.
22. )-ATPase. J. Biol. Chem. 267:14294-14303.
23. Marcusson, E.G., B.F. Horazdovsky, J.L. Cereghino, E. Gharakhanian, and S.D. Emr. 1994. The sorting receptor for yeast carboxypeptidase Y is en- coded by the VPS10 gene. Cell. 77:579-586.
24. Munro, S. 1991. Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention. EMBO (Eur. Mol. Biol. Organ.) J. 10:3577-3588.
25. Nilsson, T., J.M. Lucocq, D. Mackay, and G. Warren. 1991. The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization. EMBO (Eur. Mol. Biol. Organ.) J. 10:3567-3575.
26. Nilsson, T., P. Slusarewicz, M.H. Hoe, and G. Warren. 1993. Kin recognition. A model for the retention of Golgi enzymes. FEBS Lett. 330:1-4.
27. Nothwehr, S.F., and T.H. Stevens. 1994. Sorting of membrane proteins in the yeast secretory pathway. J. Biol. Chem. 269:10185-10188.
28. Nothwehr, S.F., C.J. Roberts, and T.H. Stevens. 1993. Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues. J Cell Biol. 121:1197-1209.
29. Nothwehr, S.F., E. Conibear, and T.H. Stevens. 1995. Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane. J. Cell Biol. 129:35-46.
30. Nothwehr, S.F., N.J. Bryant, and T.H. Stevens. 1996. The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins. Mol. Cell. Biol. 16:2700-2707.
31. Paravicini, G., B.F. Horazdovsky, and S.D. Emr. 1992. Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Mol. Biol. Cell. 3:415-427.
32. Pelham, H.R., and S. Munro. 1993. Sorting of membrane proteins in the secretory pathway. Cell. 75:603-605.
33. Piper, R.C., A.A. Cooper, H. Yang, and T.H. Stevens. 1995. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J. Cell Biol. 131:603-617.
34. Piper, R.C., E.A. Whitters, and T.H. Stevens. 1994. Yeast Vps45p is a Sec1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles. Eur. J. Cell Biol. 65:305-318.
35. Raymond, C.K., I. Howald-Stevenson, C.A. Vater, and T.H. Stevens. 1992. Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol. Biol. Cell. 3:1389-1402.
36. Redding, K., C. Holcomb, and R.S. Fuller. 1991. Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. J. Cell Biol. 113:527-538.
37. Roberts, C.J., S.F. Nothwehr, and T.H. Stevens. 1992. Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment. J. Cell Biol. 119:69-83.
38. Rothman, J.E. 1994. Mechanisms of intracellular protein transport. Nature (Lond.). 372:55-63.
39. Schafer, W., A. Stroh, S. Berghofer, J. Seiler, M. Vey, M.L. Kruse, H.F. Kern, H.D. Klenk, and W. Garten. 1995. Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO (Eur. Mol. Biol. Organ.) J. 14:2424-2435.
40. Schekman, R., and L. Orci. 1996. Coat proteins and vesicle budding. Science (Wash. DC). 271:1526-1533.
41. Schimmoller, F., and H. Riezman. 1993. Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast. J. Cell Sci. 106:823-830.
42. Sherman, F., G.R. Fink, and J. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 61-64.
43. Sprague, G.F., and J. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae. In The Molecular and Cellular Biology of the Yeast Saccharomyces cerevisiae. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 657-744.
44. Swift, A.M., and C.E. Machamer. 1991, A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein. J. Cell Biol. 115:19-30.
45. Takahashi, S., T. Nakagawa, T. Banno, T. Watanabe, K. Murakami, and K. Nakayama. 1995. Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain. J. Biol. Chem. 270:28397-28401.
46. Townsley, F.M., D.W. Wilson, and H.R. Pelham. 1993. Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. EMBO (Eur. Mol. Biol. Organ.) J. 12:2821-2829.
47. Voorhees, P., E. Deignan, E. van Donselaar, J. Humphrey, M.S. Marks, P.J. Peters, and J.S. Bonifacino. 1995. An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface. EMBO (Eur. Mol. Biol. Organ.) J. 14:4961-1975.
48. Wilcox, C.A., and R.S. Fuller. 1991. Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway. J. Cell Biol. 115:297-307.
49. Wilcox, CA., K. Redding, R. Wright, and R.S. Fuller. 1992. Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole. Mol. Biol. Cell. 3:1353-1371.
50. Wilsbach, K., and G. Payne. 1993. Dynamic retention of TGN membrane proteins in Saccharomyces cerevisiae. Trends Cell Biol. 3:426-432.
51. Wong, S.H., and W. Hong. 1993. The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans Golgi network localization. J. Biol. Chem. 268:22853-22862.