X-ray structure of antistasin at 1.9 Å resolution and its modelled complex with blood coagulation factor Xa

EMBO Journal

Volumn 16, Issue 17, 1997, Pages 5151-5161

  Lapatto, Risto ^c   Krengel, Ute ^a   Schreuder, Herman A ^d   Arkema, Anita ^a   De Boer, Bijtske ^a   Kalk, Kor H ^a   Hol, Wim G J ^e   Grootenhuis, Peter D J ^b   Mulders, John W M ^b   Dijkema, Rein ^b   Theunissen, Henri J M ^b   Dijkstra, Bauke W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NV ORGANON   (Netherlands)

^c UNIVERSITY OF HELSINKI   (Finland)

^d SANOFI   (France)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Antistasin; Crystal structure; Factor Xa; Protease inhibitor; Thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING INHIBITOR; DOCKING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; HUMAN; LEECH; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTICOAGULANTS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; INVERTEBRATE HORMONES; LEECHES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

HAEMENTERIA OFFICINALIS; HIRUDINIDA;

EID: 0030852320     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.17.5151     Document Type: Article

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