Trefoil factor expression in normal and diseased human salivary glands

Human Pathology

Volumn 31, Issue 4, 2000, Pages 509-515

  Devine, Deirdre A ^a,c   High, Alec S ^a,b,c   Owen, Paul J ^a,c   Poulsom, Richard ^a,c   Bonass, William A ^a,c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS DENTAL INSTITUTE   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Gene expression; RT PCR; Salivary glands; Trefoil factors; Wound healing peptides

Indexed keywords

TREFOIL PEPTIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SALIVARY GLAND DISEASE;

EID: 0034022603     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hp.2000.6549     Document Type: Article

References (37)

1. May F.E. Wesdey B.R. Trefoil proteins: Their role in normal and malignant-cells J Pathol 183 1997 4 7
2. Wright N.A. Hoffmann W. Otto W.R. Rolling in the clover: Trefoil factor family (TFF)-domain peptides, cell migration and cancer FEBS Lett 408 1997 121 123
3. Poulsom R. Wright N.A. Trefoil peptides: A newly recognised family of epithelial mucin-associated molecules Am J Physiol 28 1993 G205 G213
4. Rio M.C. Bellocq J.P. Daniel J.Y. Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa Science 241 1988 705 707
5. Rio M.C. Chenard M.P. Wolf C. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract Gastroenterology 100 1991 375 379
6. Hanby A.M. Poulsom R. Singh S. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil pepticles human spasmolytic polypeptide and pS2 in the human stomach Gastroenterology 105 1993 1110 1116
7. (correction published on p 12230) Podolsky D.K. Lynch-Devaney K. Stow J.L. Identification of human intestinal trefoil factor J Biol Chem 268 1993 6694 6702
8. Kindon H. Pothoulakis C. Thim L. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein Gastroenterology 109 1995 516 523
9. Ludeking A. Fegert P. Blin N. Osmotic changes and ethanol modify TFF expression in gastrointestinal cell lines FEBS Lett 439 1998 180 184
10. Lefebvre O. Chenard M.P. Masson R. Gastric-mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein Science 274 1996 259 262
11. Dignass A. Lynch-Devaney K. Kindon H. Trefoil pepticles promote epithelial migration through a transforming growth factor β-independent pathway J Clin Invest 94 1994 376 383
12. Chinery R. Cox H.M. Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor Br J Pharmacol 115 1995 77 80
13. Chinery R. Playford R.J. Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacininduced gastric damage in the rat Clin Sci 88 1995 401 403
14. Alison M.R. Chinery R. Poulsom R. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor andtransforming growth factor alpha mRNAs in rat stomach J Pathol 175 1995 405 414
15. Hirohita M. Awatsuji H. Furukawa Y. Cytokine regulation of pS2 gene expression in mouse astrocytes Biochem Mol Biol Int 33 1994 515 520
16. Sambrook J. Fritsch E.F. Maniatis T. ed 2 Molecular Cloning: A Laboratory Manual 1989 Cold Spring Harbor Press Cold Spring Harbor, NY
17. Jakowlew S.B. Breathnach R. Jeltsch J.M. Sequence of the pS2 mRNA induced by estrogen in human breast cancer cell line MCF-7 Nucl Acids Res 12 1984 2861 2878
18. Tomasetto C. Rio M.C. Gautier C. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma Eur Mol Biol Org J 9 1990 407 414
19. Shtivelman E. Lifshitz B. Gale R.P. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene Cell 47 1986 277 284
20. Poulsom R. Hanby A.M. Lalani E.-N. Intestinal trefoil factor (TFF3) and pS2 (TFFI), but not spasmolytic polypeptide (TFF2) mRNAs are co-expressed in normal, hyperplastic, andneoplastic human breast epithelium J Pathol 183 1997 30 38
21. Poulsom R. Lotigcroft J.M. Jeffrey R.E. A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens Eur J Histochem 42 1998 121 132
22. Zandvliet D.W.J. Hanby A.M. Austin C.A. Analysis of foetal expression sites of human type II DNA topoisomerase a and R mRNAs by in situ hybridisation Biochem Biophys Acta 1307 1996 239 247
23. Bonass W.A. High A.S. Owen P. Expression of β-defensin genes in human salivary glands Oral Microbiol Immunol 14 1999 371 374
24. Jagla W. Wiede A. Hinz M. Secretion of TFF-peptides by human salivary glands Cell Tissue Res 298 1999 161 166
25. Jeffrey P.J. Oates P.S. Wang T.C. Spasmolytic polypeptide: A trefoil peptide secreted by rat gastric mucous cells Gastroenterology 106 1994 336 345
26. Chinery R. Bates P.A. De A. Characterisation of the single copy trefoil peptides, intestinal trefoil factor and pS2, and their ability to form covalent dimers FEBS Lett 357 1995 117 123
27. Marchbank T. Westley B.R. May F.E.B. Dimerization of human pS2 (TFFI) plays a key role in its protective/healing effects J Pathol 185 1998 153 158
28. Hauser F. Poulsom R. Chinery R. hPLB, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer associated cell lineage and the uterus Proc Nad Acad Sci USA 90 1993 6961 6965
29. Sarraf C.E. Alison M.R. Ansari T.W. Subcellular distribution of peptides associated with gastric mucosal healing and neoplasia Microsc Res Tech 31 1995 234 247
30. Wright N.A. Pike C. Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells Nature 343 1990 82 85
31. Henry J.A. Bennett M.K. Piggott N.H. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours Br J Cancer 64 1991 677 682
32. Olsen P.S. Poulsen S.S. Kirkegard P. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection Gastroenterology 87 1984 103 108
33. Helmrath M.A. Shin C.A. Fox J.W. Adaptation after small bowel resection is attenuated by sialoadenectomy: The role for endogenous epidermal growth factor Surgery 124 1998 848 854
34. Rao R.K. Thomas D.W. Pepperl S. Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity Dig Dis Sci 42 1997 2175 2181
35. Tan X.D. Liu Q.P. Hsueh W. Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: Priming and enhancing effects of mucin Biochem J 338 1999 745 751
36. Babyatsky M.W. de Beaumont M. Thim L. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats Gastroenterology 110 1996 489 497
37. Playford R.J. Marchbank T. Chinery R. Human spasmolytic polypeptide is a cryoprotective agent which stimulates cell migration Gastroenterology 108 1995 108 116