Human trefoil peptides: Genomic structure in 21 q22.3 and coordinated expression

European Journal of Human Genetics

Volumn 4, Issue 6, 1996, Pages 308-315

  Gött, Peter ^a   Beck, Stefanie ^a   Machado, José Carlos ^a   Carneiro, Fatima ^a   Schmitt, Holger ^a   Blin, Nikolaus ^a  

^a University of Porto   (Portugal)

Author keywords

Bacterial artificial chromosomes; Gene expression; Hsp sml1; MTF TFF3; P domain; Ps2 bcei; Transcriptional regulation; Trefoil peptide

Indexed keywords

TREFOIL PEPTIDE;

ARTICLE; CANCER CELL CULTURE; CHROMOSOME 21Q; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA TRANSCRIPTION; EXON; GENE CLUSTER; GENE STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STOMACH CANCER; STOMACH MUCOSA; STOMACH POLYP; TRANSCRIPTION REGULATION;

EID: 0030452083     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1159/000472224     Document Type: Article

References (4)

1. Thim L: A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). FEBS Lett 1989;250:85-90.
2. Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R: hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBOJ 1990;9:407-414.
3. Hoffmann W, Hauser F: The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia? Trends Biochem Sci 1993;18:239-243.
4. Kindon H, Pothoulakis C, Thim L, Lynch Devaney K, Podolsky DK: Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein. Gastroenterology 1995;109:516-523.