Role for cyclin D1 in UVC-induced and p53-mediated apoptosis

Cell Death and Differentiation

Volumn 6, Issue 6, 1999, Pages 565-569

  Hiyama, Hirofumi ^a   Reeves, Steven A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Cell cycle; Cyclin D1; p53; UVC

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL LEVEL; CONTROLLED STUDY; DNA DAMAGE; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET RADIATION;

EID: 0033009825     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400524     Document Type: Article

References (15)

1. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ and Reed SI (1994) P53-dependent inhibition of cyclin dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013-1023
2. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
3. El-Deiry W et al (1993) WAF1, potential mediator of p53 tumor suppression. Cell 75: 817-825
4. Harper JW, Adami GR, Wei N, Keyomarsi K and Ellege SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816
5. Sofer-Levi Y and Resnitzky D (1996) Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E. Oncogene 13: 2431-2437
6. Kranenburg O, van der Eb AJ and Zantema A (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15: 46-54
7. Qin X-Q, Livingston DM, Kaelin Jr WG and Adams PD (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91: 10918-10922
8. Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T and Yuan Z-M (1997) Role for E2F in DNA damage-induced entry of cells into S phase. Cancer Res. 57: 3640-3643
9. Pagano M, Theodoras AM, Tam SW and Draetta GF (1994) Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8: 1627-1639
10. Poon RYC, Toyoshima H and Hunter T (1995) Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell. 6: 1197-1213
11. Hiyama H, Iavarone A, LaBaer J and Reeves SA (1997) Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression. Oncogene 14: 2533-2542
12. Gadbois DM, Bradbury EM and Lehnert BE (1997) Control of radiation-induced G1 arrest by cell-substratum interactions. Cancer Res. 57: 1151-1156
13. Zwijsen RML, Klompmaker R, Wientjens EBHGM, Kristel PMP, van der Burg B and Michalides RJAM (1996) Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit. Mol. Cell. Biol. 16: 2554-2560
14. Han EK, Begemann M, Sgambato A, Soh J, Doki Y, Xing W, Liu W and IB W (1996) Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ. 7: 699-710
15. Lu X and Lane DP (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndrome? Cell 75: 765-778