α2-Macroglobulin-mediated degradation of amyloid β1-42: A mechanism to enhance amyloid β catabolism

Experimental Neurology

Volumn 167, Issue 2, 2001, Pages 385-392

  Lauer, D ^a   Reichenbach, A ^a   Birkenmeier, G ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alzheimer's disease; Amyloid ; Oral enzyme therapy; Proteinase; Proteinase inhibitor; 2 macroglobulin

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 2 MACROGLOBULIN; ALPHA 2 MACROGLOBULIN INHIBITOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CHYMOTRYPSIN A; IODINE 125; METHYLAMINE; PHLOGENZYM; SOYBEAN TRYPSIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; CAPILLARY FLOW; CATABOLISM; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

EID: 0035136630     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7569     Document Type: Article

References (36)

1. Absorption of exogenous and endogenous proteolytic enzymes
2. Alpha-2 macroglobulin is genetically associated with Alzheimer disease
3. Transport of proteolytic enzymes across Caco-2 cell monolayers
4. α2-Macroglobulin, a multifunctional binding protein with targeting characteristics
5. Estrogen-stimulated transcytosis of desialylated ligands and alpha2 macroglobulin in rat liver
6. Modulation of the alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein by interferon-gamma in human astroglial cells
7. Intestinal absorption of undegraded proteins in men: Presence of bromelain in plasma after oral intake
8. Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype
9. The pathogenesis of senile plaques
10. Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons
11. Alpha2-macroglobulin as a beta-amyloid peptide-binding plasma protein
12. Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells: Potential significance for the processing of Alzheimer beta-amyloid precursor protein
13. Enterohepatic circulation of digestive enzymes as a conservation mechanism
14. Renal fibrosis: Role of impaired proteolysis and potential therapeutic strategies
15. Identification of the major Abetal-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
16. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease
17. Oral biovailability of proteolytic enzymes
18. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40: Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
19. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs
20. Alzheimer disease: Curly fibers and tangles in organs other than brain
21. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
22. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein
23. Prostate-specific antigen forms complexes with human alpha 2-macroglobulin and binds to the alpha 2-macroglobulin receptor/LDL receptor-related protein
24. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier
25. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex
26. Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
27. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
28. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein
29. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
30. Alzheimer's disease: A central role for amyloid
31. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
32. Alpha2-macroglobulins: Structure, shape and mechanism of proteinase complex formation
33. The plasmin system is induced by and degrades amyloid-beta aggregates
34. The subunits of alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein, native and transformed alpha2-macroglobulin and interleukin 6 in Alzheimer's disease
35. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology?