Regulation of human neutrophil-mediated cartilage proteoglycan degradation by phosphatidylinositol-3-kinase

Immunology

Volumn 102, Issue 1, 2001, Pages 59-66

  Hii, C S T ^a,b,c   Marin, L A ^a,b   Halliday, D ^a,b,c   Roberton, D M ^a   Murray, A W ^a   Ferrante, A ^a,b  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; BUCLADESINE; CYCLIC AMP; FORSKOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEOGLYCAN; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CATTLE; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; NEUTROPHIL; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY BURST; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; TISSUE INJURY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARTHRITIS, JUVENILE RHEUMATOID; CARTILAGE, ARTICULAR; CATTLE; CELL ADHESION; CULTURE TECHNIQUES; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; NEUTROPHILS; PROTEOGLYCANS; SYNOVIAL FLUID;

EID: 0035129471     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01156.x     Document Type: Article

References (37)

1. The polymorphonuclear cell in rheumatoid arthritis
2. Mechanisms of neutrophil-mediated cartilage damage in vitro: The role of lysosomal enzymes, hydrogen peroxide and hypochlorous acid
3. Interferon gamma increases human neutrophil-mediated cartilage proteoglycan degradation
4. Adhesion and TNF priming in neutrophil-mediated cartilage damage
5. Granulocyte-macrophage colony-stimulating factor augments neutrophil-mediated cartilage degradation and neutrophil adherence
6. Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants
7. Tumour necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients
8. Role of cytokines in rheumatoid arthritis
9. Integrins and inside out signal transduction: Converging signals from PKC and PIP3
10. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
11. Role of stress-activated mitogen-activated protein kinase (p38) in β2 integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst
12. G-protein-coupled receptors and Fcγ-receptor mediate activation of Akt/protein kinase B in human phagocytes
13. Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascade in human neutrophils
14. Activation of multiple protein kinases induced by cross-linking of Fc gamma RII in human neutrophils
15. Role of the extracellular signal-regulated protein kinase cascade in human neutrophil killing of S. aureus and C. albicans and in migration
16. p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNFα or fMLP
17. Different sensitivities of neutrophil responses to a selective protein kinase C inhibitor Ro 31-8425: Redundancy in signal transduction
18. The involvement of phosphatidylinositol 3-kinase in crystal-induced human neutrophil activation
19. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: Role in activation of reduced nicotinamide adenine dinucleotide oxidase
20. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen activated protein kinase
21. Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus
22. Separation of mononuclear and polymorphonuclear leukocytes from human blood by the one-step Hypaque-Ficoll method is dependent on blood column height
23. Interleukin-10 stimulation of phosphatidylinositol-3-kinase and p70, S6 kinase is required for the proliferation but not the anti-inflammatory effects of the cytokine
24. Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells
25. Stimulation of neutrophils by tumour necrosis factor
26. The PI3K-PDK1 connection: More than just a road to PKB
27. Central role for G protein-coupled phosphoinositide 3-kinase γ in flammation
28. Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated, CD11b/CD18-dependent cell-cell adhesion of human neutrophils: Evidence for an ERK-independent pathway
29. Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin-G and elastase from polymorphonuclear leukocytes
30. Cytokine-induced respiratory burst of human neutrophils: Dependence on extracellular matrix and CD11/CD18
31. The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression
32. Effect of a selective protein kinase C inhibitor, Ro 31-8425, on MAC-1 expression and adhesion of human neutrophils
33. Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex
34. Activation of the protein kinase ERK5/BMK1 by receptor tryosine kinases
35. Phagocytic cells: Products of oxygen metabolism
36. ras and phosphatidylinositol 3-kinase
37. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase