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Volumn 105, Issue 1, 2001, Pages 261-272

Effect of viscosity on the kinetics of α-helix and β-hairpin formation

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; AMINO ACIDS; CHEMICAL RELAXATION; COMPUTER SIMULATION; GLUCOSE; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; PROTEINS; REACTION KINETICS; STATISTICAL MECHANICS; SUGAR (SUCROSE); VISCOSITY OF LIQUIDS;

EID: 0035128362     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp0022048     Document Type: Article
Times cited : (161)

References (46)
  • 33
    • 33645917578 scopus 로고    scopus 로고
    • note
    • hairpin = -2.9 kcal/mol). Muñoz et al. have already pointed out that in their model the hairpin transition state contains backbone-backbone hydrogen bonds that place it at a lower energy than the unfolded state, providing a ready explanation of the apparent negative activation energy obtained from the two-state analysis. At least part of the negative activation energy obtained from a two-state analysis of helix formation may have a similar explanation, but this issue requires further exploration.
  • 38
    • 0001540218 scopus 로고
    • BT). However, as γ → 0, as in a gas at low pressure, collisions are too infrequent to constantly supply the transition state with energized molecules, and eq 9 which assumes Brownian motion is no longer valid. In this low friction (inertial) limit Kramers showed that the rate increases with increasing friction. Approximate expressions connecting the high and low friction regimes have been developed (Skinner, J. L.; Wolynes, P. G. J. Chem. Phys. 1978, 69, 2143-2150).
    • (1978) J. Chem. Phys. , vol.69 , pp. 2143-2150
    • Skinner, J.L.1    Wolynes, P.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.