Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord

Pain

Volumn 64, Issue 3, 1996, Pages 553-557

  Cruz, Francisco ^a,b   Avelino, António ^a   Coimbra, Antonio ^a  

^a University of Porto   (Portugal)

^b HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

Bladder; Capsaicin; Desensitization; Hypogastric nerve; Pelvic nerve; Rat; Visceral pain

Indexed keywords

CAPSAICIN; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DESENSITIZATION; FEMALE; HYPOGASTRIC NERVE; IMMUNOCYTOCHEMISTRY; NONHUMAN; PAIN; PELVIC NERVE; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD; TOPICAL DRUG ADMINISTRATION;

EID: 0030003938     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00157-3     Document Type: Article

References (28)

1. Bahns, E., Ernsberger, U., Jänig, W. and Nelke, A., Functional characteristics of lumbar visceral afferent fibers from the urinary bladder and urethra in the cat. Pflügers Arch., 407 (1986) 510-518.
2. Barbanti, G., Maggi, C.A., Beneforti, P., Baroldi, P. and Turini, D., Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract. Br. J. Urol., 71 (1993) 686-691.
3. Bernstein, J.E., Korman, N.J., Bickers, D.R. and Dahl, M.V., Topical capsaicin treatment of chronic postherpetic neuralgia, J. Am. Acad. Dermatol., 21 (1988) 265-270.
4. Birder, L.A., Roppolo, J.R., Iadarola, M.J. and de Groat, W.C., Electrical stimulation of visceral afferent pathways in the pelvic nerve increases c-fos in the rat lumbosacral spinal cord. Neurosci. Lett., 129 (1991) 193-196.
5. Birder, L.A. and de Groat, W.C., Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat. Neuroscience, 12 (1992) 4878-4889.
6. Craft, R.M., Carlisi, V.J., Mattia, A., Herman, R.M. and Porreca, F., Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat, Pain, 55 (1993) 205-215.
7. Cruz, F., Avelino, A., Lima, D. and Coimbra, A., Activation of c-fos protooncogene in the spinal cord following noxious stimulation of the urinary bladder. Somatosens. Motor Res., 11 (1994a) 319-325.
8. Cruz, F., Avelino, A., Lima, D. and Coimbra, A., C-fos expression following noxious stimulation of the urinary bladder is reduced by topical capsaicin treatment. Soc. Neurosci. Abst., 20 (1994b) 234.11.
9. Fitzgerald, M., Capsaicin and sensory neurones: a review, Pain, 15 (1983) 109-130.
10. Fowler, C.A., Jewkes, D., McDonald, W.I., Lynn, B. and de Groat, W.C., Intravesical capsaicin for neurogenic bladder dysfunction. Lancet, 339 (1992) 1239.
11. Herdegen, T., Kovary, K., Leah, J. and Bravo, R., Specific temporal and spatial distribution of Jun, Fos and Krox-24 proteins in spinal neurones following noxious trassynaptic stimulation, J. Comp. Neurol., 313 (1992) 178-191.
12. Häbler, H.J., Jänig, W. and Koltzenburg, M., Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat, J. Physiol. (Lond.), 425 (1990) 545-562.
13. Lynn, B., Capsaicin: actions on nociceptive C-fibers and therapeutic potential, Pain, 41 (1990) 61-69.
14. Lynn, B., Ye, W. and Cotsell, B., The actions of capsaicin applied topically to the skin of the rat on C-fibre afferents, antidromic vasodilation and substance P levels. Br. J. Pharmacol., 107 (1992) 400-406.
15. Maggi, C.A., Capsaicin and primary afferent neurons: from basic science to human therapy?, J. Aut. Nerv. System, 33 (1991) 1-14.
16. Maggi, C.A., Barbanti, G., Santicioli, P., Beneforti, P., Misuri, D. Meli. A. and Turini, D., Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of the micturition reflex in humans. J. Urol., 142 (1989) 150-154.
17. Maggi, C.A., Patachini, R., Tramontana, M., Amann, R., Giuliani, S. and Santicioli, P., Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons. Neuroscience, 37 (1990) 531-539.
18. McMahon, S.B., Lewin, G. and Bloom, S.R., The consequences of long-term topical capsaicin application in the rat, Pain, 44 (1991) 301-310.
19. Menétrey, D., Gannon, A., Levine, J.D. and Basbaum, A.L., Expression of c-fos protein in interneurons and projecting neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J. Comp. Neurol., 285 (1989) 177-195.
20. Nadelhaft, I. and Booth, A.M., The location and morphology of preganglionic neurones and the distribution of visceral afferents from the pelvic nerve of the rat. An HRP study, J. Comp. Neurol., 226 (1984) 238-245.
21. Neuhuber, W., The central projections of visceral primary afferent neurons of the inferior mesenteric plexus and hypogastric nerve and the location of the related sensory and preganglionic sympathetic cells bodies in the rat, Anat. Embryol., 164 (1982) 413-425.
22. Sengupta, J.N. and Gebhart, G.F., Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J. Neurophysiol., 72 (1994) 2420-2430.
23. Szallasi, A. and Blumberg, P.M., Specific binding of resiniferatoxin, an ultrapotent capsaicin analog by dorsal root ganglion membranes, Brain Res., 524 (1990) 106-111.
24. Szallasi, A., Conte, B., Goso, C., Blumberg, P.M. and Manzini, S., Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat, Life Sci., 52 (1993) 221-226.
25. Tandan, R., Topical capsaicin in painful diabetic neuropathy. Neurology, 40 (Suppl. 1) (1990) p4.
26. Uemura, E., Fletcher, T.F., and Bradley, W.E., Distribution of lumbar and sacral afferent axons in submucosa of cat urinary bladder, Anat. Rec., 183 (1975) 579-588.
27. Watson, C.P.N., Evans, R.J. and Watt, V.R., Post-herpetic neuralgia and topical capsaicin, Pain, 33 (1988) 333-340.
28. Watson, C.P.N., Evans, R.J. and Watt, V.R., The post-mastectomy pain syndrome and the effects of topical capsaicin, Pain, 38 (1989) 177-186.